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    Pkig protein kinase inhibitor, gamma [ Mus musculus (house mouse) ]

    Gene ID: 18769, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pkigprovided by MGI
    Official Full Name
    protein kinase inhibitor, gammaprovided by MGI
    Primary source
    MGI:MGI:1343086
    See related
    Ensembl:ENSMUSG00000035268 AllianceGenome:MGI:1343086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKIgamma
    Summary
    Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; tongue; and vertebral axis musculature. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Ubiquitous expression in testis adult (RPKM 82.9), heart adult (RPKM 72.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 84.4 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163500306..163568078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163658211..163726158)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2057 Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene serine incorporator 3 Neighboring gene STARR-positive B cell enhancer ABC_E10159 Neighboring gene STARR-positive B cell enhancer ABC_E9208 Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase upstream regulatory elements Neighboring gene adenosine deaminase Neighboring gene cellular communication network factor 5 Neighboring gene potassium channel, subfamily K, member 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation. Zhao L, et al. Int J Biochem Cell Biol, 2006. PMID 16870489
    2. Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus. Chen X, et al. J Biol Chem, 2005 Jan 28. PMID 15557275
    3. Protein kinase inhibitor γ reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor. Chen X, et al. Stem Cells, 2013 Dec. PMID 23963683, Free PMC Article
    4. Characterization of the mouse matrilin-4 gene: a 5' antiparallel overlap with the gene encoding the transcription factor RBP-l. Wagener R, et al. Genomics, 2001 Aug. PMID 11549321
    5. Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing. Piazzon N, et al. J Mol Cell Biol, 2012 Dec. PMID 22641646

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that the downregulation of PKIgamma may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells.
      Title: Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation.
    2. endogenous levels of PKI regulate PKA signaling
      Title: Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase inhibitor gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039390.3 → NP_001034479.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001034479.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000096704.3, ENSMUST00000099105.9
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    2. NM_001039391.2 → NP_001034480.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001034480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AK164716, BY343638, BY617655, CJ051558
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000068344.7, ENSMUST00000064703.13
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    3. NM_001164053.2 → NP_001157525.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001157525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000120145.2, ENSMUST00000126182.8
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    4. NM_001164055.1 → NP_001157527.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001157527.1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000126223.2, ENSMUST00000164399.8
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    5. NM_001277096.1 → NP_001264025.1  cAMP-dependent protein kinase inhibitor gamma isoform 2

      See identical proteins and their annotated locations for NP_001264025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 4. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL591490
      UniProtKB/TrEMBL
      B7ZC22
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 69
      PKI; cAMP-dependent protein kinase inhibitor

    6. NM_001420659.1 → NP_001407588.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    7. NM_001420660.1 → NP_001407589.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    8. NM_001420661.1 → NP_001407590.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    9. NM_001420662.1 → NP_001407591.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    10. NM_001420663.1 → NP_001407592.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    11. NM_001420664.1 → NP_001407593.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    12. NM_001420665.1 → NP_001407594.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    13. NM_001420666.1 → NP_001407595.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    14. NM_001420668.1 → NP_001407597.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    15. NM_001420669.1 → NP_001407598.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    16. NM_001420670.1 → NP_001407599.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    17. NM_001420671.1 → NP_001407600.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    18. NM_001420672.1 → NP_001407601.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      Q3TP50

    19. NM_001420673.1 → NP_001407602.1  cAMP-dependent protein kinase inhibitor gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL591490

    20. NM_001420674.1 → NP_001407603.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591490

    21. NM_001420675.1 → NP_001407604.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591490

    22. NM_001420676.1 → NP_001407605.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591490

    23. NM_011106.3 → NP_035236.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_035236.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000105027.3, ENSMUST00000109400.3
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163500306..163568078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70139.1 GenPept UniProtKB/Swiss-Prot:O70139

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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