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    Pkib protein kinase inhibitor beta, cAMP dependent, testis specific [ Mus musculus (house mouse) ]

    Gene ID: 18768, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pkibprovided by MGI
    Official Full Name
    protein kinase inhibitor beta, cAMP dependent, testis specificprovided by MGI
    Primary source
    MGI:MGI:101937
    See related
    Ensembl:ENSMUSG00000019876 AllianceGenome:MGI:101937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkibeta; Prkacn2
    Summary
    Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of cAMP-dependent protein kinase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; femur; gut; integumental system; and reproductive system. Orthologous to human PKIB (cAMP-dependent protein kinase inhibitor beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 8.2), cerebellum adult (RPKM 3.8) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B4; 10 29.22 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (57508077..57617208)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (57631981..57741112)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:57250127-57250428 Neighboring gene STARR-seq mESC enhancer starr_26749 Neighboring gene serine incorporator 1 Neighboring gene STARR-seq mESC enhancer starr_26750 Neighboring gene ribosomal protein L48, pseudogene 1 Neighboring gene predicted gene, 18253 Neighboring gene STARR-positive B cell enhancer mm9_chr10:57463328-57463629 Neighboring gene STARR-seq mESC enhancer starr_26751 Neighboring gene peptidylprolyl isomerase A pseudogene 10_506.1 Neighboring gene fatty acid binding protein 7, brain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Blanchet E, et al. Cell Rep, 2015 Feb 24. PMID 25704817, Free PMC Article
    2. Reproductive function in protein kinase inhibitor-deficient mice. Belyamani M, et al. Mol Cell Biol, 2001 Jun. PMID 11359903, Free PMC Article
    3. The mouse Prkacn2 gene encoding protein kinase A inhibitor 2 is located on proximal chromosome 10. Scarpetta MA, et al. Mamm Genome, 1996 Dec. PMID 8995769
    4. Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain. Seasholtz AF, et al. Proc Natl Acad Sci U S A, 1995 Feb 28. PMID 7878050, Free PMC Article
    5. Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse. Scarpetta MA, et al. J Biol Chem, 1993 May 25. PMID 7684369

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase inhibitor beta
    Names
    PKI-beta
    protein kinase, cAMP-dependent, catalytic, inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039050.1 → NP_001034139.1  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001034139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
      Source sequence(s)
      AK156950, BC052351
      Consensus CDS
      CCDS23855.1
      UniProtKB/TrEMBL
      F8WGJ1, Q3TZU5, Q5M8R3
      Related
      ENSMUSP00000067532.7, ENSMUST00000066028.13
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    2. NM_001039051.2 → NP_001034140.1  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001034140.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
      Source sequence(s)
      AC102647, AC168055, AK005281
      Consensus CDS
      CCDS23855.1
      UniProtKB/TrEMBL
      F8WGJ1, Q3TZU5, Q5M8R3
      Related
      ENSMUSP00000075374.6, ENSMUST00000075992.12
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    3. NM_001039052.1 → NP_001034141.1  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001034141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
      Source sequence(s)
      BC061162, CAAA01212555
      Consensus CDS
      CCDS23855.1
      UniProtKB/TrEMBL
      F8WGJ1, Q3TZU5, Q5M8R3
      Related
      ENSMUSP00000135280.2, ENSMUST00000177325.8
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    4. NM_001039053.2 → NP_001034142.2  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001034142.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
      Source sequence(s)
      AC102647, AC168055, AK005281
      Consensus CDS
      CCDS23855.1
      UniProtKB/TrEMBL
      F8WGJ1, Q3TZU5, Q5M8R3
      Related
      ENSMUSP00000135835.2, ENSMUST00000177473.8
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    5. NM_001190402.1 → NP_001177331.1  cAMP-dependent protein kinase inhibitor beta isoform 2

      See identical proteins and their annotated locations for NP_001177331.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
      Source sequence(s)
      AC102647, AC168055, AK005281
      Consensus CDS
      CCDS23855.1
      UniProtKB/TrEMBL
      F8WGJ1, Q3TZU5, Q5M8R3
      Related
      ENSMUSP00000135666.2, ENSMUST00000175852.2
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor

    6. NM_008863.4 → NP_032889.3  cAMP-dependent protein kinase inhibitor beta isoform 1

      See identical proteins and their annotated locations for NP_032889.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC102647, AC168055, AK083875
      Consensus CDS
      CCDS23854.1
      UniProtKB/TrEMBL
      F7D7A9, Q8BNE5
      Related
      ENSMUSP00000093329.4, ENSMUST00000095668.10
      Conserved Domains (1) summary
      pfam02827
      Location:41 → 109
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      57508077..57617208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512602.4 → XP_006512665.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      See identical proteins and their annotated locations for XP_006512665.1

      UniProtKB/TrEMBL
      F7D7A9, Q8BNE5
      Conserved Domains (1) summary
      pfam02827
      Location:41 → 109
      PKI; cAMP-dependent protein kinase inhibitor

    2. XM_017313847.3 → XP_017169336.1  cAMP-dependent protein kinase inhibitor beta isoform X1

      UniProtKB/TrEMBL
      F7D7A9, Q8BNE5
      Conserved Domains (1) summary
      pfam02827
      Location:41 → 109
      PKI; cAMP-dependent protein kinase inhibitor

    3. XM_006512604.5 → XP_006512667.1  cAMP-dependent protein kinase inhibitor beta isoform X2

      UniProtKB/TrEMBL
      Q5M8R3
      Conserved Domains (1) summary
      pfam02827
      Location:16 → 84
      PKI; cAMP-dependent protein kinase inhibitor

    4. XM_006512605.5 → XP_006512668.1  cAMP-dependent protein kinase inhibitor beta isoform X3

      See identical proteins and their annotated locations for XP_006512668.1

      UniProtKB/TrEMBL
      F8WGJ1, Q3TZU5, Q5M8R3
      Conserved Domains (1) summary
      pfam02827
      Location:9 → 77
      PKI; cAMP-dependent protein kinase inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04758.1 GenPept UniProtKB/Swiss-Prot:Q04758

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