Prkcz protein kinase C, zeta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkczprovided by MGI
Official Full Name: protein kinase C, zetaprovided by MGI
Primary source: MGI:MGI:97602
See related: Ensembl:ENSMUSG00000029053 AllianceGenome:MGI:97602
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pkcz; zetaPKC; aPKCzeta; nPKC-zeta
Summary: Enables protein serine/threonine kinase activity. Involved in positive regulation of T-helper 2 cell differentiation and positive regulation of cytokine production. Acts upstream of or within several processes, including neuron projection extension; protein localization to plasma membrane; and protein phosphorylation. Located in several cellular components, including axon hillock; myelin sheath abaxonal region; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 34.2), cerebellum adult (RPKM 31.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 86.17 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155344579..155445856, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155260118..155361428, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCzeta/NF-kappaB pathway.
Title: KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCζ/NF-κB pathway.
Inverse Correlation of TRIM32 and Protein Kinase C zeta in T Helper Type 2-Biased Inflammation.
Title: Inverse Correlation of TRIM32 and Protein Kinase C ζ in T Helper Type 2-Biased Inflammation.
Wheat germ-derived peptide ADWGGPLPH abolishes high glucose-induced oxidative stress via modulation of the PKCzeta/AMPK/NOX4 pathway.
Title: Wheat germ-derived peptide ADWGGPLPH abolishes high glucose-induced oxidative stress via modulation of the PKCζ/AMPK/NOX4 pathway.
Hypusine biosynthesis in beta cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Title: Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
PKCzeta/ADAR2 axis is a critical regulator of colorectal cancer metastases through modulation of miR-200 levels.
Title: The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.
Study of cutaneous wound healing processes using mutant mice with genetic deletion of each atypical protein kinase C (aPKC isoform) revealed that aPKCs are not functionally equivalent; aPKClambda, but not aPKCzeta, plays a primary role in cutaneous wound healing.
Title: Atypical protein kinase C isoforms differentially regulate directional keratinocyte migration during wound healing.
Deletion of protein kinase M zeta within the nucleus accumbens recapitulated the increase in cocaine seeking behavior in knock-out mice, but only in male animals.
Title: PKMζ in the nucleus accumbens acts to dampen cocaine seeking.
protein kinase M zeta expression in the anterior cingulate cortex is enhanced by peripheral nerve injury in a transcription-independent manner.
Title: Transcription-independent expression of PKMζ in the anterior cingulate cortex contributes to chronically maintained neuropathic pain.
this study elucidates the role of the aPKC-CBP pathway in modulating neurovascular remodeling and functional recovery following focal ischemic stroke.
Title: The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery.
HIF regulation of HOIL-1L targets the phosphorylated PKC-zeta for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase, avoiding significant lung injury.
Title: HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prkcz (e-PCR), detects polymorphism
- UniSTS:472840

Prkcz (e-PCR), detects polymorphism
- UniSTS:507178

NoName (e-PCR)
- UniSTS:548157

Prkcz (e-PCR), detects polymorphism
- UniSTS:144201

R74924 (e-PCR)
- UniSTS:125526

Prkcz (e-PCR), detects polymorphism
- UniSTS:507992

Prkcz (e-PCR), detects polymorphism
- UniSTS:507993

Prkcz (e-PCR), detects polymorphism
- UniSTS:507994

Prkcz (e-PCR), detects polymorphism
- UniSTS:507995

AI098070 (e-PCR)
- UniSTS:159336

RH126922 (e-PCR)
- UniSTS:207741

RH125130 (e-PCR)
- UniSTS:161952

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 2 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 2 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon hillock	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	IGI Inferred from Genetic Interaction more info	PubMed
located_in myelin sheath abaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein kinase C zeta type

Names: atypical protein kinase C; protein kinase C zeta subspecies

NP_001034168.1

EC 2.7.11.13

NP_001342107.1

EC 2.7.11.13

NP_001411727.1

EC 2.7.11.13

NP_001411728.1

EC 2.7.11.13

NP_001411729.1

EC 2.7.11.13

NP_001411730.1

EC 2.7.11.13

NP_001411731.1

EC 2.7.11.13

NP_001411732.1

EC 2.7.11.13

NP_001411733.1

EC 2.7.11.13

NP_032886.2

EC 2.7.11.13

XP_006538719.1

EC 2.7.11.13

XP_017175531.1

EC 2.7.11.13

XP_030109177.1

EC 2.7.11.13

XP_036019727.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039079.3 → NP_001034168.1 protein kinase C zeta type isoform b

See identical proteins and their annotated locations for NP_001034168.1

Status: VALIDATED

Source sequence(s)

AL670227, AL670413

Consensus CDS

CCDS19027.1

UniProtKB/TrEMBL

Q3V341

Related

ENSMUSP00000099467.5, ENSMUST00000103178.11

Conserved Domains (1) summary

cl21453
Location:53 → 409

PKc_like; Protein Kinases, catalytic domain
NM_001355178.2 → NP_001342107.1 protein kinase C zeta type isoform c

Status: VALIDATED

Source sequence(s)

AL670227, AL670413

UniProtKB/TrEMBL

A4QPC7

Conserved Domains (2) summary

pfam00130
Location:23 → 73

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:128 → 484

PKc_like; Protein Kinases, catalytic domain
NM_001424798.1 → NP_001411727.1 protein kinase C zeta type isoform d

Status: VALIDATED

Source sequence(s)

AL670227, AL670413
NM_001424799.1 → NP_001411728.1 protein kinase C zeta type isoform e

Status: VALIDATED

Source sequence(s)

AL670227, AL670413
NM_001424800.1 → NP_001411729.1 protein kinase C zeta type isoform f

Status: VALIDATED

Source sequence(s)

AL670227, AL670413
NM_001424801.1 → NP_001411730.1 protein kinase C zeta type isoform g

Status: VALIDATED

Source sequence(s)

AL670227, AL670413
NM_001424802.1 → NP_001411731.1 protein kinase C zeta type isoform h

Status: VALIDATED

Source sequence(s)

AL670227, AL670413
NM_001424803.1 → NP_001411732.1 protein kinase C zeta type isoform i

Status: VALIDATED

Source sequence(s)

AL670227, AL670413
NM_001424804.1 → NP_001411733.1 protein kinase C zeta type isoform j

Status: VALIDATED

Source sequence(s)

AL670227, AL670413
NM_008860.4 → NP_032886.2 protein kinase C zeta type isoform a

See identical proteins and their annotated locations for NP_032886.2

Status: VALIDATED

Source sequence(s)

AL670227, AL670413

Consensus CDS

CCDS19026.1

UniProtKB/Swiss-Prot

A2AD76, Q02956, Q3UHM5, Q7TST7

UniProtKB/TrEMBL

A4QPC7

Related

ENSMUSP00000030922.8, ENSMUST00000030922.15

Conserved Domains (4) summary

cd06404
Location:16 → 98

PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...

smart00220
Location:252 → 518

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00130
Location:131 → 183

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:236 → 592

PKc_like; Protein Kinases, catalytic domain

RNA

NR_188944.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL670227, AL670413

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

155344579..155445856 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538656.4 → XP_006538719.1 protein kinase C zeta type isoform X2

See identical proteins and their annotated locations for XP_006538719.1

UniProtKB/TrEMBL

Q3V341

Conserved Domains (1) summary

cl21453
Location:53 → 409

PKc_like; Protein Kinases, catalytic domain
XM_036163834.1 → XP_036019727.1 protein kinase C zeta type isoform X2

UniProtKB/TrEMBL

Q3V341

Conserved Domains (1) summary

cl21453
Location:53 → 409

PKc_like; Protein Kinases, catalytic domain
XM_030253317.1 → XP_030109177.1 protein kinase C zeta type isoform X2

UniProtKB/TrEMBL

Q3V341

Conserved Domains (1) summary

cl21453
Location:53 → 409

PKc_like; Protein Kinases, catalytic domain
XM_017320042.3 → XP_017175531.1 protein kinase C zeta type isoform X2

UniProtKB/TrEMBL

Q3V341

Conserved Domains (1) summary

cl21453
Location:53 → 409

PKc_like; Protein Kinases, catalytic domain