Pip5k1b phosphatidylinositol-4-phosphate 5-kinase, type 1 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pip5k1bprovided by MGI
Official Full Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 betaprovided by MGI
Primary source: MGI:MGI:107930
See related: Ensembl:ENSMUSG00000024867 AllianceGenome:MGI:107930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: STM7; Pipk5b; PIP5KIbeta; PI4P5K-I[b]; PIP5K1-beta
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within phosphatidylinositol biosynthetic process. Located in cytosol. Is expressed in several structures, including brain. Orthologous to human PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: This record was renamed from Pip5k1a to Pip5k1b to conform to the annotation of human. [03 Apr 2007]
Expression: Broad expression in large intestine adult (RPKM 14.5), genital fat pad adult (RPKM 9.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 19.44 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (24272158..24533236, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (24294794..24555872, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PIP5k1beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation.
Title: PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation.
synthesis of PtdIns(4,5)P(2) mediated by PIP5KIbeta is rate limiting for apical but not basolateral endocytosis in polarized kidney cells
Title: PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.
The results suggested that PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis.
Title: Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.
after stimulation of a G protein-coupled receptor, IP(3) is completely derived from a rapidly synthesized discrete pool of PIP(2) synthesized by PIP5KIalpha and PIP5KIbeta
Title: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.
PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis
Title: Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.
These results indicate that both Arf6 and PIP5K are involved in integrin-dependent bacterial uptake, and that Arf6 participates in both activation of PIP5K as well as in other events associated with bacterial uptake.
Title: Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake.
phosphatidylinositol phosphate kinase type I alpha is a negative regulator of FcepsilonRI-mediated cellular responses and anaphylaxis.
Title: Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling
Title: Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.
findings indicate that synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by the three phosphatidylinositol 4-phosphate 5-kinase (PIP5K) isoforms Ialpha, Ibeta and Igamma is controlled by Rho GTPases
Title: Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW742912 (e-PCR)
- UniSTS:209450

D19Mit117 (e-PCR), detects polymorphism
- UniSTS:128331

AI844522 (e-PCR)
- UniSTS:166138

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Names: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta; PIP5KI-beta; phosphatidylinositol 4-phosphate 5-kinase type I beta; ptdIns(4)P-5-kinase 1 beta

NP_032872.1

EC 2.7.1.68

XP_006526826.1

EC 2.7.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008846.3 → NP_032872.1 phosphatidylinositol 4-phosphate 5-kinase type-1 beta

See identical proteins and their annotated locations for NP_032872.1

Status: VALIDATED

Source sequence(s)

AC150898, AI844522, AK146100

Consensus CDS

CCDS37940.1

UniProtKB/Swiss-Prot

O70335, P70181, Q8JZY6

Related

ENSMUSP00000025800.9, ENSMUST00000025800.15

Conserved Domains (1) summary

cd17307
Location:27 → 400

PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

24272158..24533236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526763.5 → XP_006526826.1 phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1

See identical proteins and their annotated locations for XP_006526826.1

UniProtKB/Swiss-Prot

O70335, P70181, Q8JZY6

Conserved Domains (1) summary

cd17307
Location:27 → 400

PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins