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    Pigf phosphatidylinositol glycan anchor biosynthesis, class F [ Mus musculus (house mouse) ]

    Gene ID: 18701, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pigfprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Fprovided by MGI
    Primary source
    MGI:MGI:99462
    See related
    Ensembl:ENSMUSG00000024145 AllianceGenome:MGI:99462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human PIGF (phosphatidylinositol glycan anchor biosynthesis class F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 37.0), bladder adult (RPKM 17.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E4; 17 56.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87304686..87332972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (86997259..87025401, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10976 Neighboring gene predicted gene, 57642 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:87357353-87357462 Neighboring gene STARR-positive B cell enhancer ABC_E1948 Neighboring gene STARR-positive B cell enhancer ABC_E1512 Neighboring gene predicted gene, 50012 Neighboring gene ras homolog family member Q Neighboring gene STARR-positive B cell enhancer ABC_E7564 Neighboring gene STARR-positive B cell enhancer ABC_E493 Neighboring gene cysteine-rich PDZ-binding protein Neighboring gene predicted gene, 30421 Neighboring gene predicted gene, 24648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the murine GPI anchor synthesis gene Pigf, a homologue of the human PIGF gene. Ohishi K, et al. Genomics, 1996 Jun 15. PMID 8786134
    2. Altered tumor vessel maturation and proliferation in placenta growth factor-producing tumors: potential relationship to post-therapy tumor angiogenesis and recurrence. Taylor AP, et al. Int J Cancer, 2003 Jun 10. PMID 12673673
    3. Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF. Ohishi K, et al. Genomics, 1995 Oct 10. PMID 8575782
    4. A mouse model for cystinuria type I. Peters T, et al. Hum Mol Genet, 2003 Sep 1. PMID 12923163
    5. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781593

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-glycan biosynthesis class F protein
    Names
    PIG-F
    phosphatidylinositol glycan, class F
    NP_001398330.1
    NP_001398331.1
    NP_001398332.1
    NP_001398333.1
    NP_001398334.1
    NP_001398335.1
    NP_001398336.1
    NP_001398337.1
    NP_001398338.1
    NP_001398339.1
    NP_001398340.1
    NP_001398341.1
    NP_032864.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411401.1 → NP_001398330.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492
      UniProtKB/Swiss-Prot
      O09101

    2. NM_001411402.1 → NP_001398331.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492
      UniProtKB/Swiss-Prot
      O09101

    3. NM_001411403.1 → NP_001398332.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492
      UniProtKB/Swiss-Prot
      O09101

    4. NM_001411404.1 → NP_001398333.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492
      UniProtKB/Swiss-Prot
      O09101

    5. NM_001411405.1 → NP_001398334.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    6. NM_001411406.1 → NP_001398335.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    7. NM_001411407.1 → NP_001398336.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    8. NM_001411408.1 → NP_001398337.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    9. NM_001411409.1 → NP_001398338.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    10. NM_001411410.1 → NP_001398339.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    11. NM_001411411.1 → NP_001398340.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    12. NM_001411412.1 → NP_001398341.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    13. NM_008838.2 → NP_032864.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

      See identical proteins and their annotated locations for NP_032864.1

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492
      Consensus CDS
      CCDS29011.1
      UniProtKB/Swiss-Prot
      O09101
      UniProtKB/TrEMBL
      Q3V0Z0, Q8K338
      Related
      ENSMUSP00000024957.7, ENSMUST00000024957.7
      Conserved Domains (1) summary
      pfam06699
      Location:22 → 204
      PIG-F; GPI biosynthesis protein family Pig-F

    RNA

    1. NR_177246.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    2. NR_177247.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    3. NR_177248.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127695, AC154492

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      87304686..87332972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09101.1 GenPept UniProtKB/Swiss-Prot:O09101

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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