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    Phkg1 phosphorylase kinase gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 18682, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Phkg1provided by MGI
    Official Full Name
    phosphorylase kinase gamma 1provided by MGI
    Primary source
    MGI:MGI:97579
    See related
    Ensembl:ENSMUSG00000025537 AllianceGenome:MGI:97579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phkg
    Summary
    Predicted to enable ATP binding activity; enzyme binding activity; and phosphorylase kinase activity. Predicted to be involved in glycogen metabolic process and protein phosphorylation. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be part of phosphorylase kinase complex. Orthologous to human PHKG1 (phosphorylase kinase catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 14.4), heart adult (RPKM 12.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phkg1 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.26 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129892272..129907953, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129863431..129879134, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene predicted gene, 23245 Neighboring gene STARR-positive B cell enhancer ABC_E3624 Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A B2 repeat insertion generates alternate structures of the mouse muscle gamma-phosphorylase kinase gene. Maichele AJ, et al. Genomics, 1993 Apr. PMID 8486349
    2. Two exons encode the calmodulin-binding domain in the mouse phosphorylase kinase catalytic subunit gene. Bender PK, et al. Genet Anal Tech Appl, 1993 Jun-Aug. PMID 8110484
    3. Skeletal muscle phosphorylase kinase catalytic subunit mRNAs are expressed in heart tissue but not in liver. Bender PK, et al. J Biol Chem, 1987 Jun 25. PMID 3597394
    4. Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology. Amemiya T, et al. NPJ Syst Biol Appl, 2015. PMID 28725458, Free PMC Article
    5. Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice. Chamberlain JS, et al. Proc Natl Acad Sci U S A, 1987 May. PMID 3472241, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorylase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphorylase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphorylase kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
    Names
    phosphorylase kinase subunit gamma-1
    serine/threonine-protein kinase PHKG1
    NP_035209.1
    XP_011239173.1
    XP_036020769.1
    XP_036020770.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011079.3 → NP_035209.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

      See identical proteins and their annotated locations for NP_035209.1

      Status: VALIDATED

      Source sequence(s)
      AC242408, BC055102
      Consensus CDS
      CCDS19701.1
      UniProtKB/Swiss-Prot
      P07934
      Related
      ENSMUSP00000026617.7, ENSMUST00000026617.13
      Conserved Domains (1) summary
      cl21453
      Location:16 → 291
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_145486.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC242408

    2. NR_145487.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC242408

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129892272..129907953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240871.4 → XP_011239173.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 185
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036164876.1 → XP_036020769.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 185
      PKc_like; Protein Kinases, catalytic domain

    3. XM_036164877.1 → XP_036020770.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 185
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07934.3 GenPept UniProtKB/Swiss-Prot:P07934

    Gene LinkOut

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