Abcb1b ATP-binding cassette, sub-family B member 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcb1bprovided by MGI
Official Full Name: ATP-binding cassette, sub-family B member 1Bprovided by MGI
Primary source: MGI:MGI:97568
See related: Ensembl:ENSMUSG00000028970 AllianceGenome:MGI:97568
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]
Expression: Biased expression in adrenal adult (RPKM 39.4), placenta adult (RPKM 7.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 3.43 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (8848147..8916314)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (8798147..8866314)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.
Title: Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.
Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1.
Title: Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1.
Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation.
Title: Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation.
Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers.
Title: Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers.
Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice.
Title: Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice.
ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites.
Title: ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites.
Systemic Inflammation Induced Changes in Protein Expression of ABC Transporters and Ionotropic Glutamate Receptor Subunit 1 in the Cerebral Cortex of Familial Alzheimer's Disease Mouse Model.
Title: Systemic Inflammation Induced Changes in Protein Expression of ABC Transporters and Ionotropic Glutamate Receptor Subunit 1 in the Cerebral Cortex of Familial Alzheimer`s Disease Mouse Model.
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.
Title: ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.
P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss.
Title: P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss.
Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-kappaB (Nuclear Factor-kappaB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice.
Title: Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice.

Submit: New GeneRIF Correction See all GeneRIFs (105)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit47 (e-PCR), detects polymorphism
- UniSTS:130586

D5Mit48 (e-PCR), detects polymorphism
- UniSTS:130587

Abcb1 (e-PCR), detects polymorphism
- UniSTS:144173

NoName (e-PCR)
- UniSTS:235127

AW113832 (e-PCR)
- UniSTS:207751

NoName (e-PCR)
- UniSTS:225194

D5Mit146 (e-PCR), detects polymorphism
- UniSTS:130272

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled intramembrane lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ceramide floppase activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables floppase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine floppase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine flippase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in Sertoli cell barrier remodeling	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ceramide translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide translocation	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of anion channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of chloride transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent translocase ABCB1

Names: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1B; P glycoprotein 1; multidrug resistance protein 1; multidrug resistance protein 1B; phospholipid transporter ABCB1

NP_035205.1

EC 7.6.2.1

EC 7.6.2.2

XP_030110060.1

EC 7.6.2.1

EC 7.6.2.2

XP_036020766.1

EC 7.6.2.1

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011075.2 → NP_035205.1 ATP-dependent translocase ABCB1

See identical proteins and their annotated locations for NP_035205.1

Status: VALIDATED

Source sequence(s)

AK030328, AK139854, BG080311, BQ829721, BY435708, DV651684

Consensus CDS

CCDS19085.1

UniProtKB/Swiss-Prot

P06795

UniProtKB/TrEMBL

B2RUR3

Related

ENSMUSP00000009058.6, ENSMUST00000009058.10

Conserved Domains (1) summary

PTZ00265
Location:55 → 1270

PTZ00265; multidrug resistance protein (mdr1); Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

8848147..8916314

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254200.2 → XP_030110060.1 ATP-dependent translocase ABCB1 isoform X1

Conserved Domains (1) summary

PTZ00265
Location:4 → 883

PTZ00265; multidrug resistance protein (mdr1); Provisional
XM_036164873.1 → XP_036020766.1 ATP-dependent translocase ABCB1 isoform X2

UniProtKB/TrEMBL

Q3UMH0

Conserved Domains (2) summary

cd03249
Location:245 → 484

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

COG1132
Location:2 → 483

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]