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    Cdk14 cyclin dependent kinase 14 [ Mus musculus (house mouse) ]

    Gene ID: 18647, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cdk14provided by MGI
    Official Full Name
    cyclin dependent kinase 14provided by MGI
    Primary source
    MGI:MGI:894318
    See related
    Ensembl:ENSMUSG00000028926 AllianceGenome:MGI:894318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pftk1; mKIAA0834
    Summary
    Enables protein kinase activity. Predicted to be involved in mitotic cell cycle phase transition; protein phosphorylation; and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cell division; and phosphorylation. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 18.7), cortex adult (RPKM 14.0) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 A1; 5 2.61 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (4853384..5430650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (4803384..5380251, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12336 Neighboring gene predicted gene, 54299 Neighboring gene STARR-seq mESC enhancer starr_12337 Neighboring gene frizzled class receptor 1 Neighboring gene STARR-seq mESC enhancer starr_12338 Neighboring gene VISTA enhancer mm49 Neighboring gene predicted gene, 22897 Neighboring gene predicted gene, 54300 Neighboring gene STARR-seq mESC enhancer starr_12339 Neighboring gene STARR-seq mESC enhancer starr_12340 Neighboring gene STARR-seq mESC enhancer starr_12341 Neighboring gene STARR-seq mESC enhancer starr_12342 Neighboring gene predicted gene, 30151 Neighboring gene STARR-seq mESC enhancer starr_12343 Neighboring gene PTTG1IP family member 2 Neighboring gene predicted gene, 30325

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression. Zhang M, et al. Cell Rep, 2022 Sep 13. PMID 36103813
    2. CDK14 expression is down-regulated by cigarette smoke in vivo and in vitro. Pollack D, et al. Toxicol Lett, 2015 Apr 16. PMID 25680692, Free PMC Article
    3. A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice. Hashida T, et al. Endocrinology, 2002 Jul. PMID 12072416
    4. Chromosomal mapping of the PFTAIRE gene, Pftk1, a cdc2-related kinase expressed predominantly in the mouse nervous system. Lazzaro MA, et al. Genomics, 1997 Jun 15. PMID 9205131
    5. [Phosphorus-calcium metabolism in children under long-term anticonvulsant therapy]. Lluch Fernández MD, et al. An Esp Pediatr, 1991 Aug. PMID 1952457

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PFTK1 kinase regulates axogenesis during development via RhoA activation.
      Title: PFTK1 kinase regulates axogenesis during development via RhoA activation.
    2. CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression.
      Title: CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression.
    3. Cigarette smoke down regulates CDK14 levels and impairs Wnt signaling.
      Title: CDK14 expression is down-regulated by cigarette smoke in vivo and in vitro.
    4. may be a key regulator for thyrotropin-releasing hormone (TRH) action in the cerebellum through the NO-cGMP pathway
      Title: A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 14
    Names
    cell division protein kinase 14
    serine/threonine-protein kinase PFTAIRE-1
    NP_001297377.1
    NP_001411391.1
    NP_001411392.1
    NP_001411393.1
    NP_001411394.1
    NP_001411395.1
    NP_035204.2
    XP_017176197.1
    XP_036020764.1
    XP_036020765.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310448.2 → NP_001297377.1  cyclin-dependent kinase 14 isoform 2

      See identical proteins and their annotated locations for NP_001297377.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC026231, AC026233, AC044805, AC068140
      Consensus CDS
      CCDS80203.1
      UniProtKB/TrEMBL
      Q6NVF8, Q8C411
      Related
      ENSMUSP00000111111.2, ENSMUST00000115451.8
      Conserved Domains (1) summary
      cd07869
      Location:83 → 385
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

    2. NM_001424462.1 → NP_001411391.1  cyclin-dependent kinase 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC026231, AC026233, AC044805, AC068140
      UniProtKB/TrEMBL
      Q6NVF8

    3. NM_001424463.1 → NP_001411392.1  cyclin-dependent kinase 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC026231, AC026232, AC026233, AC044805, AC068140
      UniProtKB/TrEMBL
      Q6NVF8

    4. NM_001424464.1 → NP_001411393.1  cyclin-dependent kinase 14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC026231, AC026233, AC044805, AC068140

    5. NM_001424465.1 → NP_001411394.1  cyclin-dependent kinase 14 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC026231, AC026233, AC044805, AC068140
      UniProtKB/TrEMBL
      E9PVC7

    6. NM_001424466.1 → NP_001411395.1  cyclin-dependent kinase 14 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC026231, AC026233, AC044805, AC068140, AC068663

    7. NM_011074.4 → NP_035204.2  cyclin-dependent kinase 14 isoform 1

      See identical proteins and their annotated locations for NP_035204.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC026231, AC026233, AC044805, AC068140, AC068663
      Consensus CDS
      CCDS19073.1
      UniProtKB/Swiss-Prot
      O35495, O35848, Q3TNN9, Q3V319, Q6ZQ37
      Related
      ENSMUSP00000030763.7, ENSMUST00000030763.13
      Conserved Domains (2) summary
      cd07869
      Location:129 → 431
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
      PLN00009
      Location:133 → 422
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      4853384..5430650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164871.1 → XP_036020764.1  cyclin-dependent kinase 14 isoform X2

      Conserved Domains (1) summary
      cd07869
      Location:95 → 397
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

    2. XM_036164872.1 → XP_036020765.1  cyclin-dependent kinase 14 isoform X3

      UniProtKB/TrEMBL
      Q6NVF8, Q8C411
      Conserved Domains (1) summary
      cd07869
      Location:83 → 385
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

    3. XM_017320708.1 → XP_017176197.1  cyclin-dependent kinase 14 isoform X3

      UniProtKB/TrEMBL
      Q6NVF8, Q8C411
      Conserved Domains (1) summary
      cd07869
      Location:83 → 385
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35495.2 GenPept UniProtKB/Swiss-Prot:O35495

    Gene LinkOut

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