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    Pex11b peroxisomal biogenesis factor 11 beta [ Mus musculus (house mouse) ]

    Gene ID: 18632, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pex11bprovided by MGI
    Official Full Name
    peroxisomal biogenesis factor 11 betaprovided by MGI
    Primary source
    MGI:MGI:1338882
    See related
    Ensembl:ENSMUSG00000028102 AllianceGenome:MGI:1338882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEX11beta; Pex11pbeta
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in peroxisome fission and regulation of peroxisome size. Located in mitochondrion. Used to study Zellweger syndrome. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder. Orthologous to human PEX11B (peroxisomal biogenesis factor 11 beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.3), kidney adult (RPKM 12.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.1; 3 41.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96542673..96552697)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96635357..96645381)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330549D23 gene Neighboring gene Lix1-like Neighboring gene STARR-positive B cell enhancer ABC_E7929 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96439383-96439492 Neighboring gene RNA binding motif protein 8a Neighboring gene integrin, alpha 10 Neighboring gene ribosomal protein L21, pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-resolution atmospheric-pressure MALDI mass spectrometry imaging workflow for lipidomic analysis of late fetal mouse lungs. Garikapati V, et al. Sci Rep, 2019 Feb 28. PMID 30816198, Free PMC Article
    2. Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1. Koch A, et al. J Cell Sci, 2004 Aug 1. PMID 15286177
    3. PEX11 beta deficiency is lethal and impairs neuronal migration but does not abrogate peroxisome function. Li X, et al. Mol Cell Biol, 2002 Jun. PMID 12024045, Free PMC Article
    4. Peroxisomes in airway epithelia and future prospects of these organelles for pulmonary cell biology. Karnati S, et al. Histochem Cell Biol, 2009 Apr. PMID 19229552
    5. PEX11 promotes peroxisome division independently of peroxisome metabolism. Li X, et al. J Cell Biol, 2002 Feb 18. PMID 11839773, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The alterations in the brain caused by the deletion of a single allele of the Pex11beta gene, are reported.
      Title: Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Itga10

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of peroxisome size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal membrane protein 11B
    Names
    PEX11-beta
    peroxin-11B
    peroxisomal biogenesis factor 11b
    protein PEX11 homolog beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162387.1 → NP_001155859.1  peroxisomal membrane protein 11B isoform 1

      See identical proteins and their annotated locations for NP_001155859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK082279, AK082778, BB010355, BY789006, CD806660
      Consensus CDS
      CCDS17643.1
      UniProtKB/Swiss-Prot
      Q8C4G1, Q9D090, Q9Z210
      Related
      ENSMUSP00000037962.9, ENSMUST00000048766.15
      Conserved Domains (1) summary
      pfam05648
      Location:1 → 250
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    2. NM_001162388.1 → NP_001155860.1  peroxisomal membrane protein 11B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC122037
      Consensus CDS
      CCDS51006.1
      UniProtKB/TrEMBL
      E9PXK7
      Related
      ENSMUSP00000126631.2, ENSMUST00000165842.3
      Conserved Domains (1) summary
      pfam05648
      Location:4 → 236
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    3. NM_011069.3 → NP_035199.3  peroxisomal membrane protein 11B isoform 1

      See identical proteins and their annotated locations for NP_035199.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK011709, AK082778, BB010355, BY789006
      Consensus CDS
      CCDS17643.1
      UniProtKB/Swiss-Prot
      Q8C4G1, Q9D090, Q9Z210
      Related
      ENSMUSP00000113365.2, ENSMUST00000118557.8
      Conserved Domains (1) summary
      pfam05648
      Location:1 → 250
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    RNA

    1. NR_027844.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK005236, AK082778, BB010355, BY789006

    2. NR_027845.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a portion of the 5' coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA462527, AK082778, BB010355, BQ443231, BY285331, CB525686
      Related
      ENSMUST00000144962.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96542673..96552697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z210.1 GenPept UniProtKB/Swiss-Prot:Q9Z210

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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