Etv4 ets variant 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Etv4provided by MGI
Official Full Name: ets variant 4provided by MGI
Primary source: MGI:MGI:99423
See related: Ensembl:ENSMUSG00000017724 AllianceGenome:MGI:99423
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pea3; Pea-3
Summary: Enables DNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and urinary system. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 15.6), colon adult (RPKM 7.7) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.48 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101660573..101677963, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101769747..101785310, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
Title: ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
Transcription factor gene Pea3 regulates erectile function during copulation in mice.
Title: Transcription factor gene Pea3 regulates erectile function during copulation in mice.
Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.
Title: Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.
Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
Title: Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
Title: Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.
Title: Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity.
The E26 transformation-specific transcription factor, ETV4, which is induced by fibroblast growth factor signalling and acts as a repressor of ZRS activity, interacts with the histone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.
Title: Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors.
Our results will help understand the mechanism of ETV4 overexpression in CRC patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.
Title: Phosphorylation of ETV4 at Ser73 by ERK kinase could block ETV4 ubiquitination degradation in colorectal cancer.
ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
Title: ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
paracrine signaling via fibroblast growth factor 2 (Fgf2) and Mapk between these diverged tumor subclones causes enhanced expression of the Pea3 transcription factor, resulting in metastatic dissemination of the neuroendocrine tumor subclones.
Title: Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pea3 (e-PCR), detects polymorphism
- UniSTS:144160

Etv4 (e-PCR), detects polymorphism
- UniSTS:547916

AW414408 (e-PCR)
- UniSTS:180327

X63190 (e-PCR)
- UniSTS:163517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ETS translocation variant 4

Names: ETS variant protein 4; POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4); ets variant gene 4 (E1A enhancer binding protein, E1AF)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316365.1 → NP_001303294.1 ETS translocation variant 4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK144538, AL591436, BY733846, DQ832277

Consensus CDS

CCDS83903.1

UniProtKB/TrEMBL

A2A5C3, A6MDC6

Related

ENSMUSP00000017868.7, ENSMUST00000017868.7

Conserved Domains (2) summary

smart00413
Location:343 → 426

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 341

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
NM_001316366.1 → NP_001303295.1 ETS translocation variant 4 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK144538, AL591436, DQ832277

Consensus CDS

CCDS83902.1

UniProtKB/TrEMBL

A2A5C2, A6MDC6

Related

ENSMUSP00000102794.2, ENSMUST00000107176.8

Conserved Domains (2) summary

smart00413
Location:337 → 420

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 335

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
NM_008815.3 → NP_032841.2 ETS translocation variant 4 isoform 2

See identical proteins and their annotated locations for NP_032841.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK144538, AL591436, DQ832277

Consensus CDS

CCDS48937.1

UniProtKB/Swiss-Prot

P28322, Q3UMZ6

UniProtKB/TrEMBL

A6MDC6

Related

ENSMUSP00000129261.2, ENSMUST00000164750.8

Conserved Domains (2) summary

smart00413
Location:342 → 425

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 340

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

101660573..101677963 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245656.2 → XP_030101516.1 ETS translocation variant 4 isoform X7

UniProtKB/TrEMBL

A6MDC6

Conserved Domains (2) summary

smart00413
Location:338 → 421

ETS; erythroblast transformation specific domain

pfam04621
Location:8 → 336

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006532462.5 → XP_006532525.1 ETS translocation variant 4 isoform X5

UniProtKB/TrEMBL

A6MDC6

Conserved Domains (2) summary

smart00413
Location:344 → 427

ETS; erythroblast transformation specific domain

pfam04621
Location:8 → 342

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006532461.4 → XP_006532524.1 ETS translocation variant 4 isoform X4

UniProtKB/TrEMBL

A6MDC6

Conserved Domains (2) summary

smart00413
Location:383 → 466

ETS; erythroblast transformation specific domain

pfam04621
Location:54 → 381

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006532459.4 → XP_006532522.1 ETS translocation variant 4 isoform X2

UniProtKB/TrEMBL

A6MDC6

Conserved Domains (2) summary

smart00413
Location:389 → 472

ETS; erythroblast transformation specific domain

pfam04621
Location:54 → 387

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006532460.4 → XP_006532523.1 ETS translocation variant 4 isoform X3

UniProtKB/TrEMBL

A6MDC6

Conserved Domains (2) summary

smart00413
Location:384 → 467

ETS; erythroblast transformation specific domain

pfam04621
Location:54 → 382

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_006532458.4 → XP_006532521.1 ETS translocation variant 4 isoform X1

UniProtKB/TrEMBL

A6MDC6

Conserved Domains (2) summary

smart00413
Location:390 → 473

ETS; erythroblast transformation specific domain

pfam04621
Location:54 → 388

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_036156416.1 → XP_036012309.1 ETS translocation variant 4 isoform X6

UniProtKB/TrEMBL

A2A5C3, A6MDC6

Conserved Domains (2) summary

smart00413
Location:343 → 426

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 341

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_036156418.1 → XP_036012311.1 ETS translocation variant 4 isoform X8

UniProtKB/TrEMBL

A2A5C2, A6MDC6

Conserved Domains (2) summary

smart00413
Location:337 → 420

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 335

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_036156419.1 → XP_036012312.1 ETS translocation variant 4 isoform X8

UniProtKB/TrEMBL

A2A5C2, A6MDC6

Conserved Domains (2) summary

smart00413
Location:337 → 420

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 335

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_036156417.1 → XP_036012310.1 ETS translocation variant 4 isoform X6

UniProtKB/TrEMBL

A2A5C3, A6MDC6

Conserved Domains (2) summary

smart00413
Location:343 → 426

ETS; erythroblast transformation specific domain

pfam04621
Location:7 → 341

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain