Pcdh10 protocadherin 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdh10provided by MGI
Official Full Name: protocadherin 10provided by MGI
Primary source: MGI:MGI:1338042
See related: Ensembl:ENSMUSG00000049100 AllianceGenome:MGI:1338042
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Olpc; OL-pc; mKIAA1400; 6430521D13Rik; 6430703F07Rik
Summary: Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; jaw bone; and rib. Orthologous to human PCDH10 (protocadherin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 11.6), CNS E18 (RPKM 9.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 20.35 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (45332833..45389014)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (45378398..45434579)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
Title: Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene.
Title: Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene.
Olivocerebellar and corticonuclear axonal labeling confirmed that the three cortical pcdh10-positive areas were topographically connected to the nuclear and olivary pcdh10-positive areas, demonstrating their coincidence with modular structures in the olivo-cortico-nuclear loop
Title: Cerebellar modules in the olivo-cortico-nuclear loop demarcated by pcdh10 expression in the adult mouse.
Comparative semi-quantitative Pcdh 10 immunohistochemistry of the brains of human V30M transgenics did not show significant staining as peripheral nerve did, emphasizing the specificity of Pcdh 10 in peripheral nerve of amyloidogenic V30M transgenics.
Title: The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers.
male Pcdh10(+/-) mice exhibited reduced gamma-band (30-80Hz), but not lower frequency (10 and 20Hz), auditory steady state responses (ASSR). In addition, male Pcdh10(+/-) mice exhibited decreased signal-to-noise-ratio (SNR) for high gamma-band (60-100Hz) activity. Administration of a GABAB agonist remediated these electrophysiological alterations among male Pcdh10(+/-)mice.
Title: Protocadherin 10 alters γ oscillations, amino acid levels, and their coupling; baclofen partially restores these oscillatory deficits.
Studies reveals that male Pcdh10(+/-) mice have synaptic and behavioral deficits, and establish Pcdh10(+/-) mice as a novel genetic model for investigating neural circuitry and behavioral changes relevant to autism spectrum disorder.
Title: Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene.
Pcdh10, which is regulated by Pou3f1 and Hoxa5, is a mediator of like-like clustering of motor neuron cell bodies in the developing phrenic nerve.
Title: Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.
The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
Title: Pioneers in the ventral telencephalon: The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections.
Title: OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protocadherin-10

Names: OL-protocadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098170.1 → NP_001091640.1 protocadherin-10 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK038615, AK046814, BC037259

Consensus CDS

CCDS50903.1

UniProtKB/TrEMBL

E9PXQ7, Q80TE2

Related

ENSMUSP00000131073.2, ENSMUST00000166126.7

Conserved Domains (3) summary

cd11304
Location:254 → 354

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:19 → 101

Cadherin_2; Cadherin-like

pfam16492
Location:713 → 838

Cadherin_C_2; Cadherin cytoplasmic C-terminal
NM_001098171.1 → NP_001091641.1 protocadherin-10 isoform 3 precursor

See identical proteins and their annotated locations for NP_001091641.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a distinct 3' UTR and contains an alternate 3' coding exon, as compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK032337, AK034005, AK045707, AK122503, BC037259

Consensus CDS

CCDS50902.1

UniProtKB/TrEMBL

Q80TE2, Q925I8

Related

ENSMUSP00000132769.2, ENSMUST00000170695.4

Conserved Domains (3) summary

cd11304
Location:254 → 354

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:19 → 101

Cadherin_2; Cadherin-like

pfam16492
Location:713 → 838

Cadherin_C_2; Cadherin cytoplasmic C-terminal
NM_001098172.1 → NP_001091642.1 protocadherin-10 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) has a distinct 3' UTR and contains an alternate 3' coding exon, as compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA386527, AK081977, BC037259

Consensus CDS

CCDS50901.1

UniProtKB/TrEMBL

E9PX28, Q80TE2

Related

ENSMUSP00000131600.2, ENSMUST00000171554.8

Conserved Domains (3) summary

cd11304
Location:254 → 354

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:19 → 101

Cadherin_2; Cadherin-like

pfam16492
Location:713 → 838

Cadherin_C_2; Cadherin cytoplasmic C-terminal
NM_011043.3 → NP_035173.2 protocadherin-10 isoform 4 precursor

See identical proteins and their annotated locations for NP_035173.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) is unspliced, and so it has a distinct 3' UTR and lacks several 3' coding exons, as compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC037259, BC065695

Consensus CDS

CCDS79902.1

UniProtKB/TrEMBL

Q6P0A6, Q9Z1B1

Related

ENSMUSP00000141529.2, ENSMUST00000193252.2

Conserved Domains (3) summary

cd11304
Location:254 → 354

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:19 → 101

Cadherin_2; Cadherin-like

pfam16492
Location:713 → 838

Cadherin_C_2; Cadherin cytoplasmic C-terminal