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    Cntn3 contactin 3 [ Mus musculus (house mouse) ]

    Gene ID: 18488, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cntn3provided by MGI
    Official Full Name
    contactin 3provided by MGI
    Primary source
    MGI:MGI:99534
    See related
    Ensembl:ENSMUSG00000030075 AllianceGenome:MGI:99534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pang
    Summary
    Predicted to be involved in nervous system development. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in neuron projection. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Orthologous to human CNTN3 (contactin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 2.4), CNS E18 (RPKM 1.4) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cntn3 in Genome Data Viewer
    Location:
    6 D3; 6 47.52 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (102140265..102541575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (102163304..102564614, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16891 Neighboring gene predicted gene 9871 Neighboring gene STARR-seq mESC enhancer starr_16892 Neighboring gene STARR-seq mESC enhancer starr_16893 Neighboring gene STARR-seq mESC enhancer starr_16894 Neighboring gene STARR-seq mESC enhancer starr_16895 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA 4930587E11 gene Neighboring gene STARR-seq mESC enhancer starr_16896 Neighboring gene STARR-seq mESC enhancer starr_16897 Neighboring gene predicted gene, 38870 Neighboring gene STARR-seq mESC enhancer starr_16898 Neighboring gene STARR-seq mESC enhancer starr_16902 Neighboring gene STARR-seq mESC enhancer starr_16903 Neighboring gene STARR-seq mESC enhancer starr_16904 Neighboring gene STARR-seq mESC enhancer starr_16907 Neighboring gene STARR-seq mESC enhancer starr_16908 Neighboring gene STARR-seq mESC enhancer starr_16909 Neighboring gene STARR-seq mESC enhancer starr_16910 Neighboring gene STARR-seq mESC enhancer starr_16911 Neighboring gene microRNA 6373 Neighboring gene predicted gene, 26022

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis. Peng X, et al. PLoS One, 2019. PMID 31318883, Free PMC Article
    2. PANG, a gene encoding a neuronal glycoprotein, is ectopically activated by intracisternal A-type particle long terminal repeats in murine plasmacytomas. Connelly MA, et al. Proc Natl Acad Sci U S A, 1994 Feb 15. PMID 8108413, Free PMC Article
    3. BIG-1: a new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity. Yoshihara Y, et al. Neuron, 1994 Aug. PMID 8060619
    4. Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. Nikolaienko RM, et al. J Biol Chem, 2016 Oct 7. PMID 27539848, Free PMC Article
    5. The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Bouyain S, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133774, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These experiments define the regions of direct contact that mediate the binding interaction between APP and CNTN3.
      Title: Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis.
    2. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
      Title: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-3
    Names
    BIG-1
    brain-derived immunoglobulin superfamily protein 1
    plasmacytoma-associated neuronal glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008779.3 → NP_032805.2  contactin-3 precursor

      See identical proteins and their annotated locations for NP_032805.2

      Status: VALIDATED

      Source sequence(s)
      AC114423, AC153597, AC153600, AC155328
      Consensus CDS
      CCDS39581.1
      UniProtKB/Swiss-Prot
      G5E878, Q07409
      Related
      ENSMUSP00000032159.7, ENSMUST00000032159.7
      Conserved Domains (3) summary
      cd00063
      Location:598 → 695
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:498 → 504
      Ig; Ig strand A [structural motif]
      cl11960
      Location:498 → 598
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      102140265..102541575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505729.5 → XP_006505792.1  contactin-3 isoform X2

      Conserved Domains (2) summary
      cd00063
      Location:598 → 695
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:227 → 315
      Ig; Immunoglobulin domain

    2. XM_006505727.5 → XP_006505790.1  contactin-3 isoform X1

      See identical proteins and their annotated locations for XP_006505790.1

      UniProtKB/Swiss-Prot
      G5E878, Q07409
      Conserved Domains (3) summary
      cd00063
      Location:598 → 695
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:498 → 504
      Ig; Ig strand A [structural motif]
      cl11960
      Location:498 → 598
      Ig; Immunoglobulin domain

    3. XM_036165925.1 → XP_036021818.1  contactin-3 isoform X1

      UniProtKB/Swiss-Prot
      G5E878, Q07409
      Conserved Domains (3) summary
      cd00063
      Location:598 → 695
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:498 → 504
      Ig; Ig strand A [structural motif]
      cl11960
      Location:498 → 598
      Ig; Immunoglobulin domain

    4. XM_006505728.5 → XP_006505791.1  contactin-3 isoform X1

      See identical proteins and their annotated locations for XP_006505791.1

      UniProtKB/Swiss-Prot
      G5E878, Q07409
      Conserved Domains (3) summary
      cd00063
      Location:598 → 695
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:498 → 504
      Ig; Ig strand A [structural motif]
      cl11960
      Location:498 → 598
      Ig; Immunoglobulin domain

    5. XM_011241248.3 → XP_011239550.1  contactin-3 isoform X3

      Conserved Domains (2) summary
      cd00063
      Location:471 → 568
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:100 → 188
      Ig; Immunoglobulin domain

    RNA

    1. XR_001785107.3 RNA Sequence

    2. XR_377430.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07409.2 GenPept UniProtKB/Swiss-Prot:Q07409

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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