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    P2ry2 purinergic receptor P2Y, G-protein coupled 2 [ Mus musculus (house mouse) ]

    Gene ID: 18442, updated on 21-Apr-2024

    Summary

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    Official Symbol
    P2ry2provided by MGI
    Official Full Name
    purinergic receptor P2Y, G-protein coupled 2provided by MGI
    Primary source
    MGI:MGI:105107
    See related
    Ensembl:ENSMUSG00000032860 AllianceGenome:MGI:105107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2U1; P2Y2
    Summary
    Predicted to enable A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Acts upstream of or within positive regulation of mucus secretion. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to colocalize with early endosome; lysosome; and mitochondrion. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 12.3), small intestine adult (RPKM 10.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E2; 7 54.47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100645775..100661260, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100996568..101012053, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8191 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102 Neighboring gene STARR-seq mESC enhancer starr_19682 Neighboring gene STARR-seq mESC enhancer starr_19683 Neighboring gene STARR-seq mESC enhancer starr_19684 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 6 Neighboring gene STARR-seq mESC enhancer starr_19685 Neighboring gene STARR-positive B cell enhancer ABC_E1348 Neighboring gene STARR-positive B cell enhancer ABC_E11362 Neighboring gene STARR-positive B cell enhancer ABC_E4956 Neighboring gene STARR-positive B cell enhancer ABC_E8192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:108241274-108241427 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11363 Neighboring gene STARR-positive B cell enhancer mm9_chr7:108256776-108257077 Neighboring gene FCH and double SH3 domains 2 Neighboring gene ribosomal protein L27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A purinergic mechanism underlying metformin regulation of hyperglycemia. Senfeld J, et al. iScience, 2023 Jun 16. PMID 37378329, Free PMC Article
    2. P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC. Chen M, et al. BMC Musculoskelet Disord, 2021 Aug 11. PMID 34380439, Free PMC Article
    3. P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice. Dusabimana T, et al. Int J Mol Sci, 2021 May 24. PMID 34073834, Free PMC Article
    4. P2Y(2) deficiency impacts adult neurogenesis and related forebrain functions. Ali AAH, et al. FASEB J, 2021 May. PMID 33817825
    5. P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response. Dusabimana T, et al. Mol Metab, 2020 Dec. PMID 32987187, Free PMC Article

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality.
      Title: P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality.
    2. The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
      Title: The P2Y(2) receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
    3. P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-kappaB signaling favoring mononuclear cell adhesion in schistosomiasis.
      Title: P2Y(2)-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-κB signaling favoring mononuclear cell adhesion in schistosomiasis.
    4. P2Y2 receptor decreases blood pressure by inhibiting ENaC.
      Title: P2Y2 receptor decreases blood pressure by inhibiting ENaC.
    5. Deletion of the P2Y2 receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.
      Title: Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.
    6. Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
      Title: Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
    7. Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice.
      Title: Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice.
    8. P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response.
      Title: P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response.
    9. P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.
      Title: P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.
    10. P2Y2 deficiency impacts adult neurogenesis and related forebrain functions.
      Title: P2Y(2) deficiency impacts adult neurogenesis and related forebrain functions.
    Submit: New GeneRIF Correction See all GeneRIFs (86)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables A1 adenosine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables A1 adenosine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled UTP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled UTP receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood vessel diameter maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    P2Y purinoceptor 2
    Names
    ATP receptor
    P2U purinoceptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302346.1 → NP_001289275.1  P2Y purinoceptor 2

      See identical proteins and their annotated locations for NP_001289275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC151414, AK005013
      Consensus CDS
      CCDS21508.1
      UniProtKB/Swiss-Prot
      O09031, P35383, Q9CPZ4
      UniProtKB/TrEMBL
      A0A0R4J289
      Related
      ENSMUSP00000146352.2, ENSMUST00000207916.2
      Conserved Domains (1) summary
      pfam00001
      Location:51 → 306
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001302347.1 → NP_001289276.1  P2Y purinoceptor 2

      See identical proteins and their annotated locations for NP_001289276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC151414, AK005013, AK017378
      Consensus CDS
      CCDS21508.1
      UniProtKB/Swiss-Prot
      O09031, P35383, Q9CPZ4
      UniProtKB/TrEMBL
      A0A0R4J289
      Related
      ENSMUSP00000137152.2, ENSMUST00000178340.3
      Conserved Domains (1) summary
      pfam00001
      Location:51 → 306
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_008773.4 → NP_032799.2  P2Y purinoceptor 2

      See identical proteins and their annotated locations for NP_032799.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC151414, AK005013, AK017378
      Consensus CDS
      CCDS21508.1
      UniProtKB/Swiss-Prot
      O09031, P35383, Q9CPZ4
      UniProtKB/TrEMBL
      A0A0R4J289
      Related
      ENSMUSP00000036765.4, ENSMUST00000037540.5
      Conserved Domains (1) summary
      pfam00001
      Location:51 → 306
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100645775..100661260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35383.1 GenPept UniProtKB/Swiss-Prot:P35383

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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