Oxtr oxytocin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxtrprovided by MGI
Official Full Name: oxytocin receptorprovided by MGI
Primary source: MGI:MGI:109147
See related: Ensembl:ENSMUSG00000049112 AllianceGenome:MGI:109147
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OTR
Summary: Predicted to enable oxytocin receptor activity; peptide hormone binding activity; and vasopressin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of blood pressure. Predicted to be located in adherens junction; apical plasma membrane; and microvillus. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; integumental system; and small intestine. Orthologous to human OXTR (oxytocin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 71.9), mammary gland adult (RPKM 22.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.27 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (112450646..112467800, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (112473683..112491035, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxytocin receptors in the prefrontal cortex play important roles in short-term social recognition in mice.
Title: Oxytocin receptors in the prefrontal cortex play important roles in short-term social recognition in mice.
Sexually dimorphic oxytocin receptor-expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior.
Title: Sexually dimorphic oxytocin receptor-expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior.
Local CRF and oxytocin receptors correlate with female experience-driven avoidance change and hippocampal neuronal plasticity.
Title: Local CRF and oxytocin receptors correlate with female experience-driven avoidance change and hippocampal neuronal plasticity.
Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.
Title: Vasopressin receptor 1a, oxytocin receptor, and oxytocin knockout male and female mice display normal perceptual abilities towards non-social odorants.
Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome.
Title: Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome.
Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.
Title: Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.
Oxytocin Receptors in the Mouse Centrally-projecting Edinger-Westphal Nucleus and their Potential Functional Significance for Thermoregulation.
Title: Oxytocin Receptors in the Mouse Centrally-projecting Edinger-Westphal Nucleus and their Potential Functional Significance for Thermoregulation.
Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice.
Title: Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice.
Oxytocin receptor is a potential biomarker of the hyporesponsive HPA axis subtype of PTSD and might be modulated by HPA axis reactivity traits in humans and mice.
Title: Oxytocin receptor is a potential biomarker of the hyporesponsive HPA axis subtype of PTSD and might be modulated by HPA axis reactivity traits in humans and mice.
Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
Title: Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (14) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

PMC170950P1 (e-PCR)
- UniSTS:271619

PMC316374P3 (e-PCR)
- UniSTS:272964

Oxtr (e-PCR), detects polymorphism
- UniSTS:479306

NoName (e-PCR)
- UniSTS:484965

Oxtr (e-PCR), detects polymorphism
- UniSTS:527471

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables oxytocin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxytocin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in maternal behavior	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in parturition	IBA Inferred from Biological aspect of Ancestor more info
involved_in memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in response to anoxia	ISO Inferred from Sequence Orthology more info
involved_in response to steroid hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in sperm ejaculation	ISO Inferred from Sequence Orthology more info
involved_in suckling behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oxytocin receptor

Names: OT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081147.3 → NP_001074616.1 oxytocin receptor isoform 1

See identical proteins and their annotated locations for NP_001074616.1

Status: VALIDATED

Source sequence(s)

AC153594

Consensus CDS

CCDS39588.1

UniProtKB/Swiss-Prot

F8VQ78, P97926

UniProtKB/TrEMBL

Q3UPP9

Related

ENSMUSP00000051132.7, ENSMUST00000053306.8

Conserved Domains (1) summary

cd15387
Location:40 → 339

7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001410246.1 → NP_001397175.1 oxytocin receptor isoform 2

Status: VALIDATED

Source sequence(s)

AC153594

UniProtKB/TrEMBL

A0A0N4SVY6

Related

ENSMUSP00000145300.2, ENSMUST00000204027.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

112450646..112467800 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165923.1 → XP_036021816.1 oxytocin receptor isoform X1

UniProtKB/Swiss-Prot

F8VQ78, P97926

UniProtKB/TrEMBL

Q3UPP9

Conserved Domains (1) summary

cd15387
Location:40 → 339

7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors