Ovol1 ovo like zinc finger 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ovol1provided by MGI
Official Full Name: ovo like zinc finger 1provided by MGI
Primary source: MGI:MGI:1330290
See related: Ensembl:ENSMUSG00000024922 AllianceGenome:MGI:1330290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ovo1; movo1
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of meiotic cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 17.2), small intestine adult (RPKM 13.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5599165..5610603, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5549137..5560575, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation.
Title: Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation.
OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia.
Title: OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia.
that OVOL1 function as an important regulator of osteoblast differentiation by inducing BMP2 expression in MC3T3-E1 cells
Title: OVO homologue-like 1 promotes osteoblast differentiation through BMP2 expression.
OVOL1-regulated Fst and SFRP1 affect hair inductive potency of neonatal dermal cells.
Title: Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis.
OVOL1 of mouse neonatal dermal cells has a critical role in hair follicle neogenesis.
Title: OVO homolog-like 1, a target gene of the Wnt/β-catenin pathway, controls hair follicle neogenesis.
The LEF1/beta -catenin complex activates movo1
Title: The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation.
regulates pachytene progression of male germ cells, Id2 is target
Title: Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.
Ovol1 mutant mice suffered perinatal lethality accompanied by kidney epithelial cysts of embryonic onset and delayed skin barrier acquisition; Ovol2 is a downstream target of Ovol1.
Title: Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AW555629 (e-PCR)
- UniSTS:209427

BB147136 (e-PCR)
- UniSTS:186139

NoName (e-PCR)
- UniSTS:237878

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epidermal cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germline cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of keratinocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of meiotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of meiotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative transcription factor Ovo-like 1

Names: OVO homolog-like 1; mOvo1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019935.3 → NP_064319.1 putative transcription factor Ovo-like 1

See identical proteins and their annotated locations for NP_064319.1

Status: VALIDATED

Source sequence(s)

AK028577

Consensus CDS

CCDS29469.1

UniProtKB/Swiss-Prot

Q545S2, Q9WTJ2

UniProtKB/TrEMBL

Q3UME7

Related

ENSMUSP00000025861.2, ENSMUST00000025861.3

Conserved Domains (3) summary

sd00017
Location:120 → 140

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:118 → 138

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:160 → 185

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

5599165..5610603 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531676.5 → XP_006531739.1 putative transcription factor Ovo-like 1 isoform X2

See identical proteins and their annotated locations for XP_006531739.1

Conserved Domains (2) summary

sd00017
Location:58 → 78

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:98 → 123

zf-H2C2_2; Zinc-finger double domain
XM_011248605.4 → XP_011246907.1 putative transcription factor Ovo-like 1 isoform X1

UniProtKB/TrEMBL

Q3UME7

Conserved Domains (3) summary

sd00017
Location:89 → 109

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:87 → 107

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:129 → 154

zf-H2C2_2; Zinc-finger double domain
XM_006531675.5 → XP_006531738.1 putative transcription factor Ovo-like 1 isoform X2

See identical proteins and their annotated locations for XP_006531738.1

Conserved Domains (2) summary

sd00017
Location:58 → 78

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:98 → 123

zf-H2C2_2; Zinc-finger double domain
XM_011248606.4 → XP_011246908.1 putative transcription factor Ovo-like 1 isoform X2

See identical proteins and their annotated locations for XP_011246908.1

Conserved Domains (2) summary

sd00017
Location:58 → 78

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:98 → 123

zf-H2C2_2; Zinc-finger double domain