Orc1 origin recognition complex, subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Orc1provided by MGI
Official Full Name: origin recognition complex, subunit 1provided by MGI
Primary source: MGI:MGI:1328337
See related: Ensembl:ENSMUSG00000028587 AllianceGenome:MGI:1328337
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Orc1l; MmORC1
Summary: Predicted to enable DNA replication origin binding activity and chromatin binding activity. Predicted to be involved in DNA replication initiation; positive regulation of smooth muscle cell proliferation; and regulation of cell cycle process. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in liver and submandibular gland. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 4.8), liver E14.5 (RPKM 4.6) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.64 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (108436651..108472030)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (108575705..108616030)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clearance of beta-amyloid mediated by autophagy is enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes.
Title: Clearance of β-amyloid mediated by autophagy is enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes.
ORC1 in mice is essential for mitotic cell divisions but dispensable for endoreduplication.
Title: Endoreduplication of the mouse genome in the absence of ORC1.
mouse Orc1, Orc2, and Orc3 each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation
Title: Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124318 (e-PCR)
- UniSTS:161140

AJ003133 (e-PCR)
- UniSTS:185595

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	TAS Traceable Author Statement more info	PubMed
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G0 to G1 transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of origin recognition complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: origin recognition complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011015.2 → NP_035145.2 origin recognition complex subunit 1

See identical proteins and their annotated locations for NP_035145.2

Status: VALIDATED

Source sequence(s)

AJ003133, AK141741, AK164035

Consensus CDS

CCDS18453.1

UniProtKB/Swiss-Prot

A2A8R3, Q9Z1N2

UniProtKB/TrEMBL

Q8C9G3

Related

ENSMUSP00000099805.4, ENSMUST00000102744.4

Conserved Domains (5) summary

TIGR02928
Location:474 → 806

TIGR02928; orc1/cdc6 family replication initiation protein

pfam09079
Location:757 → 830

Cdc6_C; CDC6, C terminal

pfam13191
Location:483 → 533

AAA_16; AAA ATPase domain

cl02608
Location:43 → 169

BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

cl21455
Location:509 → 654

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

108436651..108472030

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001014425.1: Suppressed sequence

Description

NM_001014425.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.