Oprd1 opioid receptor, delta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oprd1provided by MGI
Official Full Name: opioid receptor, delta 1provided by MGI
Primary source: MGI:MGI:97438
See related: Ensembl:ENSMUSG00000050511 AllianceGenome:MGI:97438
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DOR; Nbor; mDOR; DOR-1
Summary: Enables G protein-coupled opioid receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adult locomotory behavior; and neuropeptide signaling pathway. Located in membrane. Is integral component of membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and neural retina. Orthologous to human OPRD1 (opioid receptor delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 3.5), cortex adult (RPKM 2.6) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 64.78 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (131834980..131872042, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (132110188..132144486, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of delta opioid receptors in mice.
Title: Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of δ opioid receptors in mice.
Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
Title: Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis.
Title: Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis.
A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
Title: A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons.
Title: Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons.
Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.
Title: Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.
Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain.
Title: Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain.
Basolateral Amygdala Drives a GPCR-Mediated Striatal Memory Necessary for Predictive Learning to Influence Choice.
Title: Basolateral Amygdala Drives a GPCR-Mediated Striatal Memory Necessary for Predictive Learning to Influence Choice.
Delta-Opioid Receptor gene is transcriptionally more diverse than previously demonstrated, producing novel protein isoforms in humans and mice.
Title: Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms.
DOR-MOR co-expression is limited to excitatory interneurons in the spinal cord dorsal horn and ventral horn motor circuits and regulates mechanical pain.
Title: Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L06322 (e-PCR)
- UniSTS:163351

GDB:511375 (e-PCR)
- UniSTS:157503

Oprd1 (e-PCR), detects polymorphism
- UniSTS:144085

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled enkephalin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled enkephalin receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled opioid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled opioid receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled opioid receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal dense core vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in spine apparatus	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: delta-type opioid receptor

Names: D-OR-1; K56; MSL-2; delta 1 opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013622.3 → NP_038650.3 delta-type opioid receptor

See identical proteins and their annotated locations for NP_038650.3

Status: VALIDATED

Source sequence(s)

AK043873, L06322

Consensus CDS

CCDS18718.1

UniProtKB/Swiss-Prot

P32300

UniProtKB/TrEMBL

A2AD37, Q8BLP9

Related

ENSMUSP00000050077.2, ENSMUST00000056336.2

Conserved Domains (2) summary

pfam00001
Location:66 → 318

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:59 → 232

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

131834980..131872042 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538628.5 → XP_006538691.1 delta-type opioid receptor isoform X1

UniProtKB/TrEMBL

B1ACW5

Conserved Domains (2) summary

cd14964
Location:35 → 61

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:27 → 280

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily