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    Or52a5b olfactory receptor family 52 subfamily A member 5B [ Mus musculus (house mouse) ]

    Gene ID: 18370, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Or52a5bprovided by MGI
    Official Full Name
    olfactory receptor family 52 subfamily A member 5Bprovided by MGI
    Primary source
    MGI:MGI:1341789
    See related
    Ensembl:ENSMUSG00000058662 AllianceGenome:MGI:1341789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3'[b]3; Olfr69; 3'beta3; MOR22-2
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    7 E3; 7 54.85 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103416484..103420801, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (103767277..103771594, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily AE member 9 Neighboring gene olfactory receptor family 51 subfamily L member 4 Neighboring gene olfactory receptor family 52 subfamily A member 5 Neighboring gene olfactory receptor family 52 subfamily Z member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells. Feingold EA, et al. Genomics, 1999 Oct 1. PMID 10512676
    2. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Bulger M, et al. Proc Natl Acad Sci U S A, 1999 Apr 27. PMID 10220430, Free PMC Article
    3. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Bulger M, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121057, Free PMC Article
    4. Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse. Hirota J, et al. Mol Cell Neurosci, 2007 Apr. PMID 17350283
    5. The chromosomal distribution of mouse odorant receptor genes. Sullivan SL, et al. Proc Natl Acad Sci U S A, 1996 Jan 23. PMID 8570653, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 69
    Names
    GA_x6K02T2PBJ9-6494485-6493535
    olfactory receptor MOR22-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013621.3 → NP_038649.2  olfactory receptor 69

      Status: VALIDATED

      Source sequence(s)
      AC127296
      Consensus CDS
      CCDS21590.1
      UniProtKB/TrEMBL
      E9Q7C5, Q9WVD7
      Related
      ENSMUSP00000102491.2, ENSMUST00000106878.3
      Conserved Domains (2) summary
      pfam00001
      Location:43 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33 → 313
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      103416484..103420801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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