Sebox SEBOX homeobox [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Seboxprovided by MGI
Official Full Name: SEBOX homeoboxprovided by MGI
Primary source: MGI:MGI:108012
See related: Ensembl:ENSMUSG00000001103 AllianceGenome:MGI:108012
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OG9; Og9x
Summary: Predicted to enable DNA binding activity. Acts upstream of or within embryo development and oogenesis. Predicted to be located in nucleus. Is expressed in several structures, including brain; craniocervical region bone; early conceptus; gonad; and skin. Orthologous to human SEBOX (SEBOX homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 4.0), cortex adult (RPKM 0.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78394328..78395907)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78503513..78505081)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sebox is important in preparing oocytes for embryonic development by orchestrating the expression of other important MEGs
Title: Associations among Sebox and other MEGs and its effects on early embryogenesis.
Sebox is a new addition to maternal effect genes that produced and stored in oocytes and function in preimplantation embryo
Title: SEBOX is essential for early embryogenesis at the two-cell stage in the mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein SEBOX

Names: OG9 homeobox; homeobox OG-9; skin-, embryo-, brain- and oocyte-specific homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.