Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntrk3provided by MGI
Official Full Name: neurotrophic tyrosine kinase, receptor, type 3provided by MGI
Primary source: MGI:MGI:97385
See related: Ensembl:ENSMUSG00000059146 AllianceGenome:MGI:97385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TrkC; Ntrk3_tv3
Summary: Predicted to enable several functions, including GPI-linked ephrin receptor activity; neurotrophin binding activity; and p53 binding activity. Acts upstream of or within several processes, including lens fiber cell differentiation; neurogenesis; and neuronal action potential propagation. Located in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and peripheral nervous system. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 7.6), CNS E18 (RPKM 6.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D2; 7 44.01 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (77825711..78228865, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (78179986..78581034, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory.
Title: TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory.
TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
Title: TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently. This signaling mechanism may be important for TrkC-mediated cytoskeletal dynamics in podocyte disease.
Title: Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation.
In a retinitis pigmentosa mouse model, TrkC activity generates phosphorylated Erk, which upregulates glial TNF-alpha, causing selective neuronal death.
Title: In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.
our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants
Title: Runx3-regulated expression of two Ntrk3 transcript variants in dorsal root ganglion neurons.
adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk mouse mutant with a pain phenotype
Title: Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
TrkC expression in E13.5 VCG neurons requires NeuroD and that TrkC expression may be necessary for the normal migration and innervations of those neurons.
Title: NeuroD regulates neuronal migration.
The dependence receptor TrkC interacts with Cobra1.TrkC killer fragment shuttles with Cobra1 to the mitochondria to engage apoptosis.
Title: The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment.
ETV6-SAM domain interface mutations block ETV6-NTRK3-induced cellular transformation
Title: Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.
This study demonistrated that NTRK3 plays a role in panic disorder by regulating hippocampus-dependent fear memories.
Title: Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit214 (e-PCR), detects polymorphism
- UniSTS:131107

NoName (e-PCR)
- UniSTS:548387

D1UIA12 (e-PCR)
- UniSTS:239693

Ntrk3 (e-PCR), detects polymorphism
- UniSTS:463954

BE106688 (e-PCR)
- UniSTS:246364

AW125844 (e-PCR)
- UniSTS:185718

Ntrk3 (e-PCR), detects polymorphism
- UniSTS:265607

Ntrk3 (e-PCR), detects polymorphism
- UniSTS:265608

Ntrk3 (e-PCR), detects polymorphism
- UniSTS:507106

Ntrk3 (e-PCR), detects polymorphism
- UniSTS:525565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables neurotrophin binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin receptor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of axon extension involved in regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens fiber cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mechanoreceptor differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination in peripheral nervous system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron fate specification	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential propagation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
NOT involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of axon extension involved in regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: NT-3 growth factor receptor

Names: GP145-TrkC; neurotrophin-3; trk-C; trkC tyrosine kinase

NP_032772.3

EC 2.7.10.1

NP_877961.1

EC 2.7.10.1

XP_006540755.1

EC 2.7.10.1

XP_011249119.1

EC 2.7.10.1

XP_036008659.1

EC 2.7.10.1

XP_036008660.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008746.5 → NP_032772.3 NT-3 growth factor receptor isoform a precursor

See identical proteins and their annotated locations for NP_032772.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC108420, AC115868, AC121082, AK164887

Consensus CDS

CCDS21371.1

UniProtKB/Swiss-Prot

A4QPD0, Q6VNS1, Q9Z2P9, Q9Z2Q0

UniProtKB/TrEMBL

A0A0A6YWL7

Related

ENSMUSP00000037909.8, ENSMUST00000039431.14

Conserved Domains (7) summary

cd05094
Location:532 → 818

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam00047
Location:214 → 299

ig; Immunoglobulin domain

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:218 → 221

Ig; Ig strand A' [structural motif]

cd04971
Location:304 → 396

IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
NM_182809.2 → NP_877961.1 NT-3 growth factor receptor isoform b precursor

See identical proteins and their annotated locations for NP_877961.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the CDS and the 3' UTR, compared to variant 1. This results in a shorter isoform (b) with a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC121082, AF035400, BE950984

Consensus CDS

CCDS21372.1

UniProtKB/Swiss-Prot

Q6VNS1

Related

ENSMUSP00000038324.8, ENSMUST00000039438.9

Conserved Domains (7) summary

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam00047
Location:214 → 299

ig; Immunoglobulin domain

pfam01462
Location:31 → 51

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:218 → 221

Ig; Ig strand A' [structural motif]

cd04971
Location:304 → 396

IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

77825711..78228865 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152766.1 → XP_036008659.1 NT-3 growth factor receptor isoform X1

UniProtKB/TrEMBL

A0A0A6YWL7

Conserved Domains (7) summary

cd05094
Location:532 → 843

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam00047
Location:214 → 299

ig; Immunoglobulin domain

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:218 → 221

Ig; Ig strand A' [structural motif]

cd04971
Location:304 → 396

IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
XM_011250817.4 → XP_011249119.1 NT-3 growth factor receptor isoform X2

See identical proteins and their annotated locations for XP_011249119.1

UniProtKB/TrEMBL

A0A0A6YWF9, A0A0A6YWL7

Related

ENSMUSP00000141534.2, ENSMUST00000193002.6

Conserved Domains (7) summary

cd05094
Location:532 → 832

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam00047
Location:214 → 299

ig; Immunoglobulin domain

pfam13855
Location:103 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:218 → 221

Ig; Ig strand A' [structural motif]

cd04971
Location:304 → 396

IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
XM_036152767.1 → XP_036008660.1 NT-3 growth factor receptor isoform X3

Conserved Domains (5) summary

cd05094
Location:362 → 673

PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C

pfam00047
Location:44 → 129

ig; Immunoglobulin domain

pfam16920
Location:1 → 38

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:48 → 51

Ig; Ig strand A' [structural motif]

cd04971
Location:134 → 226

IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
XM_006540692.4 → XP_006540755.1 NT-3 growth factor receptor isoform X4

Conserved Domains (6) summary

cd04971
Location:319 → 396

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:211 → 301

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00013
Location:31 → 56

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:105 → 128

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:104 → 160

LRR_8; Leucine rich repeat

pfam16920
Location:163 → 208

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain