Nrxn2 neurexin II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrxn2provided by MGI
Official Full Name: neurexin IIprovided by MGI
Primary source: MGI:MGI:1096362
See related: Ensembl:ENSMUSG00000033768 AllianceGenome:MGI:1096362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0921; 6430591O13Rik
Summary: Enables several functions, including calcium channel regulator activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Involved in postsynapse organization and signal transduction. Acts upstream of or within neurotransmitter secretion and synapse assembly. Part of protein-containing complex. Is expressed in several structures, including blood vessel; nervous system; and retina. Used to study autism spectrum disorder. Orthologous to human NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 41.2), frontal lobe adult (RPKM 37.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.65 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6468786..6583247)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6418756..6533217)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional deletion of Neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures.
Title: Conditional deletion of Neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures.
Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment.
Title: Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment.
Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Title: Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Presynaptic alternative splicing of neurexin-2 at SS4 had no effect on post-synaptic NMDA- or AMPA-receptor-mediated responses.
Title: Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.
Neurexin deletion induces atypical structural connectivity within socially relevant brain regions.
Title: The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.
IgSF21 interacts with neurexin2alpha to induce presynaptic differentiation of inhibitory synapses, and mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission
Title: IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.
After pan-neurexin deletions, we observed in these synapses severe but dramatically different synaptic phenotypes that ranged from major impairments in their distribution and function (climbing-fiber synapses) to large decreases in synapse numbers (parvalbumin-positive synapses) and severe alterations in action potential-induced presynaptic Ca(2+) transients (somatostatin-positive synapses).
Title: Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.
The results indicate that Nrx2alpha and NL1 are targets of Abeta oligomers and that prevention of this interaction reduces the deleterious impact of Abeta oligomers on synapses and cognition.
Title: Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.
Findings demonstrate that the heterozygous loss of alpha-neurexin I and alpha-neurexin II in mice leads to phenotypes relevant to autism and schizophrenia
Title: Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.
The loss of Nrxn2alpha plays a causal role in the genesis of autism-related behaviors in mice.
Title: Deletion of α-neurexin II results in autism-related behaviors in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (7) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN55895 (e-PCR)
- UniSTS:380695

NRXN2_1011 (e-PCR)
- UniSTS:280881

ECD05988 (e-PCR)
- UniSTS:287050

REN55693 (e-PCR)
- UniSTS:380493

REN55701 (e-PCR)
- UniSTS:380501

REN55957 (e-PCR)
- UniSTS:380757

REN55702 (e-PCR)
- UniSTS:380502

REN55704 (e-PCR)
- UniSTS:380504

REN55768 (e-PCR)
- UniSTS:380568

REN56068 (e-PCR)
- UniSTS:380868

ECD09220 (e-PCR)
- UniSTS:290264

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neuroligin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gephyrin clustering involved in postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroligin clustering involved in postsynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in postsynaptic density protein 95 clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vocal learning	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info
is_active_in presynaptic active zone membrane	NAS Non-traceable Author Statement more info
located_in presynaptic membrane	ISA Inferred from Sequence Alignment more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurexin-2

Names: neurexin II alpha; neurexin II beta; neurexin-2-alpha; neurexin-2-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205234.2 → NP_001192163.1 neurexin-2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC167245

Consensus CDS

CCDS57132.1

UniProtKB/TrEMBL

E9PUM9, Q3UGZ9

Related

ENSMUSP00000109089.2, ENSMUST00000113462.8

Conserved Domains (5) summary

smart00282
Location:509 → 659

LamG; Laminin G domain

cd00054
Location:687 → 720

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1628 → 1667

Syndecan; Syndecan domain

pfam02210
Location:939 → 1067

Laminin_G_2; Laminin G domain
NM_001205235.2 → NP_001192164.1 neurexin-2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC167245

Consensus CDS

CCDS57133.1

UniProtKB/TrEMBL

B2RX09, E9Q5N7

Related

ENSMUSP00000076424.7, ENSMUST00000077182.13

Conserved Domains (5) summary

smart00282
Location:501 → 651

LamG; Laminin G domain

cd00054
Location:679 → 712

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1428 → 1467

Syndecan; Syndecan domain

pfam02210
Location:931 → 1059

Laminin_G_2; Laminin G domain
NM_001369363.1 → NP_001356292.1 neurexin-2 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC167245

Consensus CDS

CCDS89327.1

UniProtKB/Swiss-Prot

E9Q7X7

UniProtKB/TrEMBL

Q3UGZ9

Related

ENSMUSP00000119762.2, ENSMUST00000137166.8

Conserved Domains (6) summary

smart00282
Location:516 → 666

LamG; Laminin G domain

PHA03247
Location:1433 → 1630

PHA03247; large tegument protein UL36; Provisional

cd00054
Location:694 → 727

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1635 → 1674

Syndecan; Syndecan domain

pfam02210
Location:946 → 1074

Laminin_G_2; Laminin G domain
NM_020253.4 → NP_064649.2 neurexin-2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC167245

Consensus CDS

CCDS89326.1

UniProtKB/TrEMBL

A0A494B8Y4, B2RX09

Related

ENSMUSP00000157405.2, ENSMUST00000236635.2

Conserved Domains (5) summary

smart00282
Location:509 → 659

LamG; Laminin G domain

cd00054
Location:687 → 720

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1436 → 1475

Syndecan; Syndecan domain

pfam02210
Location:939 → 1067

Laminin_G_2; Laminin G domain