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Nrp1 neuropilin 1 [ Mus musculus (house mouse) ]

Gene ID: 18186, updated on 21-Apr-2024

Summary

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Official Symbol: Nrp1provided by MGI
Official Full Name: neuropilin 1provided by MGI
Primary source: MGI:MGI:106206
See related: Ensembl:ENSMUSG00000025810 AllianceGenome:MGI:106206
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrp; NP-1; Npn1; NPN-1; C530029I03
Summary: Enables protein kinase binding activity; transmembrane signaling receptor activity; and vascular endothelial growth factor binding activity. Involved in several processes, including nervous system development; regulation of signal transduction; and vasculature development. Acts upstream of or within several processes, including morphogenesis of a branching epithelium; nervous system development; and toxin transport. Located in several cellular components, including endosome; focal adhesion; and neurofilament. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; jaw; lung; nervous system; and sensory organ. Used to study retinal vein occlusion. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 39.3), subcutaneous fat pad adult (RPKM 21.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

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Location:: 8 E2; 8 75.78 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (129085553..129231957)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (128358591..128505476)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.
Title: Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.
NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting.
Title: NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting.
Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections.
Title: Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections.
Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4[+] T cells.
Title: Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4(+) T cells.
Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent.
Title: Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent.
Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis.
Title: Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis.
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow.
Title: Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow.
USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.
Title: USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.
Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
Title: Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
Neuropilin-1 (NRP1) expression distinguishes self-reactive helper T cells in systemic autoimmune disease.
Title: Neuropilin-1 (NRP1) expression distinguishes self-reactive helper T cells in systemic autoimmune disease.

Submit: New GeneRIF Correction See all GeneRIFs (180)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:465488 (e-PCR)
- UniSTS:465488

Nrp1 (e-PCR), detects polymorphism
- UniSTS:465488

Nrp1 (e-PCR), detects polymorphism
- UniSTS:532564

Nrp (e-PCR), detects polymorphism
- UniSTS:280404

Nrp1 (e-PCR), detects polymorphism
- UniSTS:498272

D50086 (e-PCR)
- UniSTS:163450

AI121036 (e-PCR)
- UniSTS:179856

Nrp1 (e-PCR), detects polymorphism
- UniSTS:548024

RH127171 (e-PCR)
- UniSTS:208343

RH134538 (e-PCR)
- UniSTS:217818

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables semaphorin receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables semaphorin receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in VEGF-activated neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in VEGF-activated neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis involved in coronary vascular morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis involved in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basal dendrite arborization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in basal dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branchiomotor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in coronary vasculogenesis	IC Inferred by Curator more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	IC Inferred by Curator more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hepatocyte growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coronary artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal root ganglion morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facial nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facioacoustic ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration involved in autonomic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropilin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in otic placode development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to early endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Cdc42 protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in renal artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retina vasculature development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina vasculature morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semaphorin-plexin signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of substrate-dependent cell migration, cell extension	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in sympathetic ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic neuron projection guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trigeminal ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trigeminal nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trigeminal nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral trunk neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vestibulocochlear nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neurofilament	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sorting endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuropilin-1

Names: A5 protein; Neuropilin-1 precursor (A5 protein); transmembrane receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358959.2 → NP_001345888.1 neuropilin-1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC102856, AC139349

UniProtKB/TrEMBL

Q3UQY7

Conserved Domains (4) summary

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00629
Location:643 → 803

MAM; MAM domain, meprin/A5/mu

pfam11980
Location:838 → 916

DUF3481; C-terminal domain of neuropilin glycoprotein
NM_001358960.2 → NP_001345889.1 neuropilin-1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC102856, AC139349

UniProtKB/TrEMBL

Q3UQY7

Conserved Domains (4) summary

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00629
Location:650 → 810

MAM; MAM domain, meprin/A5/mu

pfam11980
Location:828 → 906

DUF3481; C-terminal domain of neuropilin glycoprotein
NM_001424858.1 → NP_001411787.1 neuropilin-1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC102856, AC139349
NM_001424859.1 → NP_001411788.1 neuropilin-1 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC102856, AC139349
NM_008737.3 → NP_032763.2 neuropilin-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_032763.2

Status: VALIDATED

Source sequence(s)

AC102856, AC139349

Consensus CDS

CCDS22790.1

UniProtKB/Swiss-Prot

P97333, Q6PAR3

UniProtKB/TrEMBL

Q3UQY7

Related

ENSMUSP00000026917.9, ENSMUST00000026917.10

Conserved Domains (4) summary

cd00041
Location:27 → 140

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:277 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00629
Location:650 → 810

MAM; MAM domain, meprin/A5/mu

pfam11980
Location:845 → 923

DUF3481; C-terminal domain of neuropilin glycoprotein