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    Nras neuroblastoma ras oncogene [ Mus musculus (house mouse) ]

    Gene ID: 18176, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nrasprovided by MGI
    Official Full Name
    neuroblastoma ras oncogeneprovided by MGI
    Primary source
    MGI:MGI:97376
    See related
    Ensembl:ENSMUSG00000027852 AllianceGenome:MGI:97376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N-ras
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of angiogenesis. Acts upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Located in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.4), placenta adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.2; 3 45.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102965643..102975230)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103058285..103067914)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4568 Neighboring gene suppressor of IKBKE 1 Neighboring gene STARR-seq mESC enhancer starr_08583 Neighboring gene cold shock domain containing E1, RNA binding Neighboring gene STARR-seq mESC enhancer starr_08584 Neighboring gene STARR-seq mESC enhancer starr_08585 Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene STARR-seq mESC enhancer starr_08586 Neighboring gene DENN domain containing 2C Neighboring gene STARR-seq mESC enhancer starr_08590 Neighboring gene STARR-seq mESC enhancer starr_08592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. Murphy BM, et al. Nat Commun, 2022 Jun 7. PMID 35672316, Free PMC Article
    2. Oncogenic N-Ras Mitigates Oxidative Stress-Induced Apoptosis of Hematopoietic Stem Cells. Ney GM, et al. Cancer Res, 2021 Mar 1. PMID 33441311, Free PMC Article
    3. Senescent bone marrow microenvironment promotes Nras-mutant leukemia. Zhou P, et al. J Mol Cell Biol, 2021 Apr 10. PMID 33196790, Free PMC Article
    4. Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo. Rahman H, et al. J Invest Dermatol, 2021 Jan. PMID 32569596
    5. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Zambetti NA, et al. Blood, 2020 May 14. PMID 32219446, Free PMC Article

    See all (209) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
      Title: A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
    2. RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
      Title: RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
    3. Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
      Title: Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
    4. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
      Title: Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
    5. Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
      Title: Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
    6. Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
      Title: Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
    7. Senescent bone marrow microenvironment promotes Nras-mutant leukemia.
      Title: Senescent bone marrow microenvironment promotes Nras-mutant leukemia.
    8. Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice.
      Title: Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice.
    9. Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity.
      Title: Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity.
    10. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
      Title: Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
    Submit: New GeneRIF Correction See all GeneRIFs (77)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of skeletal muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    GTPase NRas
    Names
    transforming protein N-Ras
    NP_001355567.1
    NP_001397438.1
    NP_001397439.1
    NP_001397440.1
    NP_001397441.1
    NP_001397442.1
    NP_035067.2
    XP_006501183.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368638.2 → NP_001355567.1  GTPase NRas

      Status: VALIDATED

      Source sequence(s)
      AC163297
      Consensus CDS
      CCDS38570.1
      UniProtKB/TrEMBL
      Q3TMF4, Q3UCX0, Q9D091
      Related
      ENSMUSP00000143391.2, ENSMUST00000200069.5
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. NM_001410509.1 → NP_001397438.1  GTPase NRas

      Status: VALIDATED

      Source sequence(s)
      AC163297
      UniProtKB/TrEMBL
      Q9D091

    3. NM_001410510.1 → NP_001397439.1  GTPase NRas

      Status: VALIDATED

      Source sequence(s)
      AC163297
      UniProtKB/TrEMBL
      Q9D091

    4. NM_001410511.1 → NP_001397440.1  GTPase NRas

      Status: VALIDATED

      Source sequence(s)
      AC163297
      UniProtKB/TrEMBL
      Q9D091
      Related
      ENSMUSP00000143644.2, ENSMUST00000199049.5

    5. NM_001410512.1 → NP_001397441.1  GTPase NRas

      Status: VALIDATED

      Source sequence(s)
      AC163297
      UniProtKB/TrEMBL
      Q9D091

    6. NM_001410513.1 → NP_001397442.1  GTPase NRas

      Status: VALIDATED

      Source sequence(s)
      AC163297
      UniProtKB/TrEMBL
      Q9D091
      Related
      ENSMUSP00000142438.2, ENSMUST00000196355.5

    7. NM_010937.3 → NP_035067.2  GTPase NRas

      See identical proteins and their annotated locations for NP_035067.2

      Status: VALIDATED

      Source sequence(s)
      AC163297
      Consensus CDS
      CCDS38570.1
      UniProtKB/TrEMBL
      Q3TMF4, Q3UCX0, Q9D091
      Related
      ENSMUSP00000029445.7, ENSMUST00000029445.13
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    RNA

    1. NR_177084.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163297
      Related
      ENSMUST00000128264.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      102965643..102975230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501120.5 → XP_006501183.1  GTPase NRas isoform X2

      See identical proteins and their annotated locations for XP_006501183.1

      UniProtKB/TrEMBL
      Q3TMF4, Q3UCX0, Q9D091
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08556.1 GenPept UniProtKB/Swiss-Prot:P08556

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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