Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc11a2provided by MGI
Official Full Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2provided by MGI
Primary source: MGI:MGI:1345279
See related: Ensembl:ENSMUSG00000023030 AllianceGenome:MGI:1345279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mk; van; DCT1; DMT1; Nramp2
Summary: Enables cobalt ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; and proton transmembrane transporter activity. Acts upstream of or within several processes, including cation transport; erythrocyte development; and multicellular organismal iron ion homeostasis. Located in several cellular components, including brush border membrane; endosome; and extracellular vesicle. Is integral component of plasma membrane. Is expressed in embryo; intestine; small intestine; and yolk sac. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 20.4), kidney adult (RPKM 16.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.29 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100285779..100322090, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100387898..100424209, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis.
Title: DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis.
Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner.
Title: Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner.
DMT1 Protects Macrophages from Salmonella Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression.
Title: DMT1 Protects Macrophages from Salmonella Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression.
Iron from nanostructured ferric phosphate: absorption and biodistribution in mice and bioavailability in iron deficient anemic women.
Title: Iron from nanostructured ferric phosphate: absorption and biodistribution in mice and bioavailability in iron deficient anemic women.
Divalent Metal Transporter 1 Knock-Down Modulates IL-1beta Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery.
Title: Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery.
Spinal NR2B phosphorylation at Tyr1472 regulates IRE(-)DMT1-mediated iron accumulation and spine morphogenesis via kalirin-7 in tibial fracture-associated postoperative pain after orthopedic surgery in female mice.
Title: Spinal NR2B phosphorylation at Tyr1472 regulates IRE(-)DMT1-mediated iron accumulation and spine morphogenesis via kalirin-7 in tibial fracture-associated postoperative pain after orthopedic surgery in female mice.
Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.
Title: Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.
Deleting DMT1 in vitro significantly reduce SC proliferation, maturation, and the myelination of DRG axons. This was accompanied by an important reduction in iron incorporation and storage.
Title: Iron Metabolism in the Peripheral Nervous System: The Role of DMT1, Ferritin, and Transferrin Receptor in Schwann Cell Maturation and Myelination.
DMT1 is necessary for normal oligodendrocyte progenitor cell maturation and is required for efficient remyelination of the adult brain.
Title: The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells.
The results indicate that global DMT1 overexpression causes decreased superoxide generation upon stimulation in inflammatory cells, which presumably delayed the promotional stage of crocidolite-induced mesothelial carcinogenesis. DMT1Tg mice with low-stamina inflammatory cells may be helpful to evaluate the involvement of inflammation in various pathologies
Title: Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

PMC129447P2 (e-PCR)
- UniSTS:270592

PMC129447P3 (e-PCR)
- UniSTS:270593

AU048745 (e-PCR)
- UniSTS:145195

NoName (e-PCR)
- UniSTS:224854

Slc11a2 (e-PCR), detects polymorphism
- UniSTS:546992

D15Mcg1 (e-PCR), detects polymorphism
- UniSTS:142012

Slc11a2 (e-PCR), detects polymorphism
- UniSTS:499136

L33415 (e-PCR)
- UniSTS:160506

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadmium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadmium ion binding	ISO Inferred from Sequence Orthology more info
enables cadmium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cadmium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cobalt ion binding	ISO Inferred from Sequence Orthology more info
enables cobalt ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cobalt ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cobalt ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ferrous iron transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables inorganic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables lead ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lead ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables nickel cation binding	ISO Inferred from Sequence Orthology more info
enables nickel cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nickel cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info
enables solute:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transition metal ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables vanadium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cadmium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cobalt ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cobalt ion transport	ISO Inferred from Sequence Orthology more info
involved_in copper ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in copper ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iron import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transport	ISO Inferred from Sequence Orthology more info
involved_in lead ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion transport	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in nickel cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within porphyrin-containing compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to manganese ion	ISO Inferred from Sequence Orthology more info
involved_in transition metal ion transport	ISO Inferred from Sequence Orthology more info
involved_in vanadium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of paraferritin complex	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: natural resistance-associated macrophage protein 2

Names: DMT-1; NRAMP 2; divalent cation transporter 1; divalent metal transporter 1; microcytic anemia, viable anaemia; solute carrier family 11 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146161.1 → NP_001139633.1 natural resistance-associated macrophage protein 2 isoform 1

See identical proteins and their annotated locations for NP_001139633.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. This variant has a stem-loop iron response element (IRE) in the 3' UTR.

Source sequence(s)

AK049856, CJ057283

Consensus CDS

CCDS49733.1

UniProtKB/Swiss-Prot

P49282

Related

ENSMUSP00000116463.2, ENSMUST00000138843.8

Conserved Domains (2) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:90 → 473

Nramp; Natural resistance-associated macrophage protein
NM_001356952.1 → NP_001343881.1 natural resistance-associated macrophage protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC139571

Conserved Domains (1) summary

cl00456
Location:1 → 203

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_008732.2 → NP_032758.2 natural resistance-associated macrophage protein 2 isoform 2

See identical proteins and their annotated locations for NP_032758.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a protein (isoform 2) with a longer and distinct C-terminus, compared to isoform 1. This variant does not have a stem-loop iron response element (IRE) in the 3' UTR.

Source sequence(s)

AK049856, CJ057283, L33415

Consensus CDS

CCDS37211.1

UniProtKB/Swiss-Prot

O54903, P49282, Q3UFV5, Q8BJL2, Q8BWV3, Q8CFA0, Q8VCU6

Related

ENSMUSP00000023774.6, ENSMUST00000023774.12

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

100285779..100322090 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245487.3 → XP_011243789.1 natural resistance-associated macrophage protein 2 isoform X1

UniProtKB/Swiss-Prot

P49282

Conserved Domains (1) summary

TIGR01197
Location:98 → 497

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
XM_006520580.4 → XP_006520643.1 natural resistance-associated macrophage protein 2 isoform X5

Conserved Domains (1) summary

cl00456
Location:1 → 203

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006520579.5 → XP_006520642.1 natural resistance-associated macrophage protein 2 isoform X3

Conserved Domains (1) summary

TIGR01197
Location:1 → 388

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
XM_030248382.2 → XP_030104242.1 natural resistance-associated macrophage protein 2 isoform X5

Conserved Domains (1) summary

cl00456
Location:1 → 203

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006520578.4 → XP_006520641.1 natural resistance-associated macrophage protein 2 isoform X2

See identical proteins and their annotated locations for XP_006520641.1

UniProtKB/Swiss-Prot

O54903, P49282, Q3UFV5, Q8BJL2, Q8BWV3, Q8CFA0, Q8VCU6

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
XM_006520577.5 → XP_006520640.1 natural resistance-associated macrophage protein 2 isoform X2

See identical proteins and their annotated locations for XP_006520640.1

UniProtKB/Swiss-Prot

O54903, P49282, Q3UFV5, Q8BJL2, Q8BWV3, Q8CFA0, Q8VCU6

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
XM_030248381.2 → XP_030104241.1 natural resistance-associated macrophage protein 2 isoform X4

Conserved Domains (1) summary

TIGR01197
Location:1 → 388

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
XM_030248383.2 → XP_030104243.1 natural resistance-associated macrophage protein 2 isoform X6

Conserved Domains (1) summary

cl00456
Location:1 → 203

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain