Ctnnd2 catenin delta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctnnd2provided by MGI
Official Full Name: catenin delta 2provided by MGI
Primary source: MGI:MGI:1195966
See related: Ensembl:ENSMUSG00000022240 AllianceGenome:MGI:1195966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nprap; Catnd2; neurojugin
Summary: Predicted to enable beta-catenin binding activity and cadherin binding activity. Acts upstream of or within learning; morphogenesis of a branching structure; and regulation of synaptic plasticity. Located in postsynaptic density. Is expressed in several structures, including central nervous system; future brain; lung; sensory organ; and spinal ganglion. Human ortholog(s) of this gene implicated in anxiety disorder; major depressive disorder; and schizophrenia. Orthologous to human CTNND2 (catenin delta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 25.6), frontal lobe adult (RPKM 25.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B2; 15 12.02 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (30172680..31029490)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (30172534..31029344)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.
Title: Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.
Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
Title: Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.
microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting delta-catenin, a novel catenin in asthma.
Title: microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting δ-catenin, a novel catenin in asthma.
the hypoxia-inducible transcriptional factor, HIF1alpha, can directly upregulate the expression of the gene Ctnnd2, which codes the protein delta-Catenin.
Title: Hypoxia induced δ-Catenin to enhance mice hepatocellular carcinoma progression via Wnt signaling.
delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
Title: δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation.
Title: δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.
Acute knockdown of delta-catenin leads to increases in spine and synapse density in hippocampal neurons during development.
Title: Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.
conditional targeting of p120 catenin in mice leads to progressive development of skin neoplasias associated with intrinsic NF-kappaB activation.
Title: Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.
Delta-catenin occurs in mouse brain dendrites along with PSD-95 in postsynaptic scaffolds. It forms stable complexes with glutamate receptors, suggesting a link between delta-catenin and glutamatergic synaptic transmission during neuronal development.
Title: Glutamate-induced delta-catenin redistribution and dissociation from postsynaptic receptor complexes.
PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability.
Title: Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Mit131 (e-PCR), detects polymorphism
- UniSTS:127493

D1Mit413 (e-PCR), detects polymorphism
- UniSTS:128777

D15Mit202 (e-PCR), detects polymorphism
- UniSTS:127570

D15Mit203 (e-PCR), detects polymorphism
- UniSTS:127571

MHAa67c8.seq (e-PCR)
- UniSTS:125269

D5S2317 (e-PCR)
- UniSTS:81271

D15Mit249 (e-PCR), detects polymorphism
- UniSTS:127620

D10Bir12 (e-PCR), detects polymorphism
- UniSTS:141479

U90331 (e-PCR)
- UniSTS:160441

Ctnnd2 (e-PCR), detects polymorphism
- UniSTS:527300

D15Mit136 (e-PCR), detects polymorphism
- UniSTS:116431

D15Mit98 (e-PCR), detects polymorphism
- UniSTS:127723

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of a branching structure	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: catenin delta-2

Names: catenin (cadherin associated protein), delta 2; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); neural plakophilin-related arm-repeat protein; neurojungin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355502.2 → NP_001342431.1 catenin delta-2 isoform 2

Status: VALIDATED

Source sequence(s)

AC105408, AC110569, AC124675, AC124993, AC134414, AC139197

Consensus CDS

CCDS88745.1

UniProtKB/Swiss-Prot

B2RR80, O35927

UniProtKB/TrEMBL

B7ZNF6

Related

ENSMUSP00000154410.2, ENSMUST00000226119.2

Conserved Domains (5) summary

smart00185
Location:577 → 617

ARM; Armadillo/beta-catenin-like repeats

pfam00514
Location:830 → 871

Arm; Armadillo/beta-catenin-like repeat

sd00043
Location:548 → 573

ARM; armadillo repeat [structural motif]

cl26464
Location:256 → 530

Atrophin-1; Atrophin-1 family

cl27106
Location:546 → 719

PLN03200; cellulose synthase-interactive protein; Provisional
NM_001411452.1 → NP_001398381.1 catenin delta-2 isoform 3

Status: VALIDATED

Source sequence(s)

AC105408, AC110569, AC124675, AC134414, AC139197
NM_001411453.1 → NP_001398382.1 catenin delta-2 isoform 3

Status: VALIDATED

Source sequence(s)

AC105408, AC110569, AC124675, AC134414, AC139197
NM_008729.3 → NP_032755.2 catenin delta-2 isoform 1

Status: VALIDATED

Source sequence(s)

AC105408, AC110569, AC124675, AC124993, AC134414, AC139197

Consensus CDS

CCDS27405.1

UniProtKB/Swiss-Prot

B2RR80, O35927

UniProtKB/TrEMBL

E9QKH8

Related

ENSMUSP00000080427.6, ENSMUST00000081728.7

Conserved Domains (3) summary

cd00020
Location:540 → 662

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam17052
Location:1050 → 1109

CAF20; Cap associated factor

sd00043
Location:548 → 573

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

30172680..31029490

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520033.4 → XP_006520096.1 catenin delta-2 isoform X1

UniProtKB/Swiss-Prot

B2RR80, O35927

Conserved Domains (5) summary

smart00185
Location:486 → 526

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:455 → 628

PLN03200; cellulose synthase-interactive protein; Provisional

PHA03247
Location:45 → 452

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:457 → 482

ARM; armadillo repeat [structural motif]

pfam00514
Location:739 → 779

Arm; Armadillo/beta-catenin-like repeat
XM_030248378.2 → XP_030104238.1 catenin delta-2 isoform X1

UniProtKB/Swiss-Prot

B2RR80, O35927

Conserved Domains (5) summary

smart00185
Location:486 → 526

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:455 → 628

PLN03200; cellulose synthase-interactive protein; Provisional

PHA03247
Location:45 → 452

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:457 → 482

ARM; armadillo repeat [structural motif]

pfam00514
Location:739 → 779

Arm; Armadillo/beta-catenin-like repeat