Npr3 natriuretic peptide receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npr3provided by MGI
Official Full Name: natriuretic peptide receptor 3provided by MGI
Primary source: MGI:MGI:97373
See related: Ensembl:ENSMUSG00000022206 AllianceGenome:MGI:97373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lgj; EF-2; stri; ANP-C; NPR-C; ANPR-C
Summary: Predicted to enable several functions, including chloride ion binding activity; peptide receptor activity; and protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; osteoclast proliferation; and positive regulation of urine volume. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart and pericardium; and lung. Used to study bone disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 24.7), subcutaneous fat pad adult (RPKM 23.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.83 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (11839982..11907287, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (11839896..11907837, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3.
Title: Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3.
NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.
Title: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.
NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-beta1/Smad pathways.
Title: NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.
Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury.
Title: Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury.
Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice.
Title: Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice.
Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.
Title: Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.
Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
Title: Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
Gene expression of proliferator-activated receptor delta and estrogen-related receptor alpha, which upregulate oxidative metabolism, was increased in the gastrocnemius muscle of NPR-C- mice, irrespective of diet.
Title: Natriuretic peptide signaling is involved in the expression of oxidative metabolism-related and muscle fiber constitutive genes in the gastrocnemius muscle.
Absence of natriuretic peptide clearance receptor attenuates TGF-beta1-induced selective atrial fibrosis and atrial fibrillation.
Title: Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation.
NPRC plays a critical role in the progression of angiotensin II-mediated atrial fibrillation and atrial dysfunction.
Title: NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (4) 1 citation
Targeted (9) 1 citation
Chemically induced (ENU) (4) 1 citation
Endonuclease-mediated (8) 1 citation

General gene information

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Markers

PMC17879P1 (e-PCR)
- UniSTS:271659

Npr3 (e-PCR), detects polymorphism
- UniSTS:526956

RH127035 (e-PCR)
- UniSTS:209072

Npr3 (e-PCR), detects polymorphism
- UniSTS:144062

PMC22098P1 (e-PCR)
- UniSTS:272097

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables natriuretic peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables natriuretic peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: atrial natriuretic peptide receptor 3

Names: Nppc receptor; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide receptor type C; longjohn; strigosus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039181.2 → NP_001034270.1 atrial natriuretic peptide receptor 3 isoform b precursor

See identical proteins and their annotated locations for NP_001034270.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to variant a.

Source sequence(s)

AC134793

Consensus CDS

CCDS88736.1

UniProtKB/TrEMBL

Q7TMG7

Related

ENSMUSP00000154180.2, ENSMUST00000228603.2

Conserved Domains (3) summary

cd06386
Location:49 → 440

PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor

cd12841
Location:466 → 501

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

pfam01094
Location:66 → 419

ANF_receptor; Receptor family ligand binding region
NM_001286395.2 → NP_001273324.1 atrial natriuretic peptide receptor 3 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, uses an alternate in-frame splice site in the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.

Source sequence(s)

AC134793

Consensus CDS

CCDS88735.1

UniProtKB/TrEMBL

A0A2I3BPR9

Related

ENSMUSP00000153895.2, ENSMUST00000228489.2

Conserved Domains (2) summary

cl10011
Location:1 → 187

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl25995
Location:212 → 247

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
NM_001411434.1 → NP_001398363.1 atrial natriuretic peptide receptor 3 isoform c

Status: VALIDATED

Source sequence(s)

AC134793

UniProtKB/TrEMBL

A0A2I3BPR9
NM_001411435.1 → NP_001398364.1 atrial natriuretic peptide receptor 3 isoform d

Status: VALIDATED

Source sequence(s)

AC134793
NM_001411436.1 → NP_001398365.1 atrial natriuretic peptide receptor 3 isoform d

Status: VALIDATED

Source sequence(s)

AC134793
NM_008728.3 → NP_032754.2 atrial natriuretic peptide receptor 3 isoform a precursor

See identical proteins and their annotated locations for NP_032754.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC134793

Consensus CDS

CCDS27386.1

UniProtKB/Swiss-Prot

G3X9E5, P70180, P97804, Q9R025, Q9R027, Q9R028

Related

ENSMUSP00000066737.4, ENSMUST00000066529.5

Conserved Domains (3) summary

cd06386
Location:49 → 440

PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor

cd12841
Location:471 → 502

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

pfam01094
Location:66 → 419

ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

11839982..11907287 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248376.1 → XP_030104236.1 atrial natriuretic peptide receptor 3 isoform X1

Conserved Domains (2) summary

cl10011
Location:1 → 187

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl25995
Location:217 → 248

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
XM_006520031.4 → XP_006520094.1 atrial natriuretic peptide receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006520094.1

Conserved Domains (2) summary

cl10011
Location:1 → 187

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl25995
Location:217 → 248

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase