Nppc natriuretic peptide type C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nppcprovided by MGI
Official Full Name: natriuretic peptide type Cprovided by MGI
Primary source: MGI:MGI:97369
See related: Ensembl:ENSMUSG00000026241 AllianceGenome:MGI:97369
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CNP; lbab
Summary: This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]
Expression: Biased expression in ovary adult (RPKM 20.5), cerebellum adult (RPKM 4.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.98 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (86594015..86598295, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (86666293..86670573, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.
Title: C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.
Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice.
Title: Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice.
The oocyte cumulus complex regulates mouse sperm migration in the oviduct.
Title: The oocyte cumulus complex regulates mouse sperm migration in the oviduct.
Effect of C-type natriuretic peptide on craniofacial skeletogenesis in mice during the pubertal growth spurt.
Title: Effect of C-type natriuretic peptide on craniofacial skeletogenesis in mice during the pubertal growth spurt.
C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis.
Title: C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis.
The mRNA-destabilizing protein Tristetraprolin targets ""meiosis arrester"" Nppc mRNA in mammalian preovulatory follicles.
Title: The mRNA-destabilizing protein Tristetraprolin targets "meiosis arrester" Nppc mRNA in mammalian preovulatory follicles.
CNP, via guanylyl cyclase-B/cyclic GMP signaling, stabilizes resident perivascular mast cells at baseline and prevents their excessive activation under pathological conditions.
Title: Stabilization of Perivascular Mast Cells by Endothelial CNP (C-Type Natriuretic Peptide).
CNP is a critical regulator of preantral follicle growth, but also provides new insight in understanding the crosstalk between oocytes and somatic cells during early folliculogenesis.
Title: C-type natriuretic peptide enhances mouse preantral follicle growth.
in ovarian follicles, following the luteinizing hormone surge, NPPC levels increase initially and then decline rapidly
Title: Impacts of macrophage colony-stimulating factor (M-CSF) on the expression of natriuretic peptide precursor type C (NPPC) and regulation of meiotic resumption.
In cultured interstitial aortic valve cells, CNP inhibited pathological differentiation via the guanylate cyclase NPR2 and not natriuretic peptide receptor 3. CNP/NPR2 signaling is a novel regulator of aortic valve development and disease.
Title: Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484952

Nppc (e-PCR), detects polymorphism
- UniSTS:526953

Nppc (e-PCR), detects polymorphism
- UniSTS:144059

Nppc (e-PCR), detects polymorphism
- UniSTS:144060

Nppc (e-PCR), detects polymorphism
- UniSTS:144061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in c-di-GMP signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cGMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glycoprotein	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cumulus cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastric emptying	IDA Inferred from Direct Assay more info	PubMed
involved_in growth plate cartilage chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth plate cartilage chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle process involved in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of uterine smooth muscle relaxation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to decreased oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxygen-glucose deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type natriuretic peptide

Names: natriuretic peptide precursor C; natriuretic peptide precursor type C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.