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    Npdc1 neural proliferation, differentiation and control 1 [ Mus musculus (house mouse) ]

    Gene ID: 18146, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Npdc1provided by MGI
    Official Full Name
    neural proliferation, differentiation and control 1provided by MGI
    Primary source
    MGI:MGI:1099802
    See related
    Ensembl:ENSMUSG00000015094 AllianceGenome:MGI:1099802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NPDC-1
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in axial skeleton; nervous system; neural retina; and thymus. Orthologous to human NPDC1 (neural proliferation, differentiation and control 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 116.4), whole brain E14.5 (RPKM 82.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Npdc1 in Genome Data Viewer
    Location:
    2 A3; 2 17.23 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25293067..25299504)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25403050..25409494)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9505 Neighboring gene suppressor APC domain containing 2 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene STARR-positive B cell enhancer ABC_E11704 Neighboring gene fucosyltransferase 7 Neighboring gene ATP-binding cassette, sub-family A member 2 Neighboring gene microRNA 3087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proliferation and differentiation properties of bipotent glial progenitor cell lines immortalized with the adenovirus E1A gene. Galiana E, et al. J Neurosci Res, 1993 Oct 1. PMID 7903403
    2. miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1. Gao H, et al. Cell Cycle, 2020 Jul. PMID 32544377, Free PMC Article
    3. Functional analysis of the NPDC-1 gene. Evrard C, et al. Gene, 2004 Dec 8. PMID 15563841
    4. Characterization and tissue expression of a novel human gene npdc1. Qu X, et al. Gene, 2001 Feb 7. PMID 11245976
    5. Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. Galiana E, et al. Proc Natl Acad Sci U S A, 1995 Feb 28. PMID 7878019, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural proliferation differentiation and control protein 1
    Names
    neural proliferation differentiation control-1 protein
    neural proliferation, differentiation and control gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420469.1 → NP_001407398.1  neural proliferation differentiation and control protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732557

    2. NM_008721.5 → NP_032747.2  neural proliferation differentiation and control protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032747.2

      Status: VALIDATED

      Source sequence(s)
      AL732557
      Consensus CDS
      CCDS15771.1
      UniProtKB/Swiss-Prot
      Q64322, Q99J69
      UniProtKB/TrEMBL
      Q925Q2
      Related
      ENSMUSP00000071387.6, ENSMUST00000071442.12
      Conserved Domains (1) summary
      pfam06809
      Location:1 → 332
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25293067..25299504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497777.5 → XP_006497840.1  neural proliferation differentiation and control protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497840.1

      UniProtKB/TrEMBL
      A2AJ23, Q8CFL4
      Conserved Domains (1) summary
      pfam06809
      Location:1 → 249
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64322.2 GenPept UniProtKB/Swiss-Prot:Q64322

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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