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    Nup50 nucleoporin 50 [ Mus musculus (house mouse) ]

    Gene ID: 18141, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nup50provided by MGI
    Official Full Name
    nucleoporin 50provided by MGI
    Primary source
    MGI:MGI:1351502
    See related
    Ensembl:ENSMUSG00000016619 AllianceGenome:MGI:1351502
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npap60; 1700030K07Rik
    Summary
    Acts upstream of or within neural tube formation. Part of nuclear pore. Is expressed in several structures, including nervous system and retina. Orthologous to human NUP50 (nucleoporin 50). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.0), placenta adult (RPKM 9.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E2; 15 40.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84800100..84827164)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84923428..84942963)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46528 Neighboring gene RIKEN cDNA 4930513L16 gene Neighboring gene predicted gene 29666 Neighboring gene STARR-positive B cell enhancer ABC_E8603 Neighboring gene RIKEN cDNA 5031439G07 gene Neighboring gene microRNA 1249 Neighboring gene predicted gene, 39558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus. Doufexis M, et al. FASEB J, 2007 Dec. PMID 17625072, Free PMC Article
    2. Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. Matsuura Y, et al. EMBO J, 2005 Nov 2. PMID 16222336, Free PMC Article
    3. Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60. Müller D, et al. EMBO J, 2000 May 15. PMID 10811608, Free PMC Article
    4. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Buchwalter AL, et al. Mol Biol Cell, 2014 Aug 15. PMID 24943837, Free PMC Article
    5. cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. Fan F, et al. Genomics, 1997 Mar 15. PMID 9073512

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that nucleoporin 50 plays an essential role in the survival of primordial germ cells during embryonic development
      Title: NUP50 is necessary for the survival of primordial germ cells in mouse embryos.
    2. Results suggest a transport-independent role for Nup50 in chromatin biology that occurs away from the NPC.
      Title: Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.
    3. Interacts with the melanocortin 2 receptor, participating in its translocation to the nucleus.
      Title: Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus.
    4. findings show that the Nup50 N-terminal domain actively displaces NLSs from importin-alpha, which would be more consistent with Nup50 functioning to coordinate import complex disassembly and importin recycling
      Title: Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup50
    Names
    50 kDa nucleoporin
    nuclear pore associated protein 60 kDa
    nucleoporin Nup50
    nucleoprotein 50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016714.2 → NP_057923.2  nuclear pore complex protein Nup50

      See identical proteins and their annotated locations for NP_057923.2

      Status: PROVISIONAL

      Source sequence(s)
      BC059239
      Consensus CDS
      CCDS27714.1
      UniProtKB/Swiss-Prot
      Q3TG43, Q3TN17, Q6P1F4, Q6PAL4, Q8C2Y6, Q9CU02, Q9JIH2, Q9JK85
      Related
      ENSMUSP00000131457.3, ENSMUST00000165443.4
      Conserved Domains (2) summary
      cd13170
      Location:348 → 464
      RanBD_NUP50; Nucleoporin 50 Ran-binding domain
      pfam08911
      Location:3 → 64
      NUP50; NUP50 (Nucleoporin 50 kDa)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      84800100..84827164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159225.1 → XP_036015118.1  nuclear pore complex protein Nup50 isoform X1

      Conserved Domains (2) summary
      cd13170
      Location:389 → 505
      RanBD_NUP50; Nucleoporin 50 Ran-binding domain
      pfam08911
      Location:3 → 105
      NUP50; NUP50 (Nucleoporin 50 kDa)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIH2.3 GenPept UniProtKB/Swiss-Prot:Q9JIH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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