Nr4a3 nuclear receptor subfamily 4, group A, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr4a3provided by MGI
Official Full Name: nuclear receptor subfamily 4, group A, member 3provided by MGI
Primary source: MGI:MGI:1352457
See related: Ensembl:ENSMUSG00000028341 AllianceGenome:MGI:1352457
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CHN; TEC; CSMF; Nor1; MINOR; NOR-1
Summary: This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression: Biased expression in adrenal adult (RPKM 14.5), CNS E18 (RPKM 3.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.07 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (48045098..48086446)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (48045078..48086447)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond.
Title: NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond.
High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice.
Title: High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice.
Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration.
Title: Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration.
Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-kappaB Signaling Pathway.
Title: Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-κB Signaling Pathway.
miR106b5p modulates acute pulmonary embolism via NOR1 in pulmonary artery smooth muscle cells.
Title: miR‑106b‑5p modulates acute pulmonary embolism via NOR1 in pulmonary artery smooth muscle cells.
Early programming of CD8(+) T cell response by the orphan nuclear receptor NR4A3.
Title: Early programming of CD8(+) T cell response by the orphan nuclear receptor NR4A3.
study demonstrates that miR-665 upregulation is associated with metastasis and poor survival in BC patients, and mechanistically, miR-665 enhances progression of BC via NR4A3/MEK signaling pathway.
Title: miR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer.
NOR-1 is involved in the transcriptional programme leading to Hypertensive cardiac hypertrophy.
Title: Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy.
NR4A3 could inhibit post-acute myocardial infarction inflammation responses via JAK2-STAT3/NF-kappaB signaling.
Title: The protective role of NR4A3 in acute myocardial infarction by suppressing inflammatory responses via JAK2-STAT3/NF-κB pathway.
The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation.
Title: The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC133552P1 (e-PCR)
- UniSTS:270631

PMC133552P2 (e-PCR)
- UniSTS:270632

D5Wox30 (e-PCR)
- UniSTS:239934

AI573420 (e-PCR)
- UniSTS:164235

Nr4a3 (e-PCR), detects polymorphism
- UniSTS:256688

Nr4a3 (e-PCR), detects polymorphism
- UniSTS:256689

Nr4a3 (e-PCR), detects polymorphism
- UniSTS:536541

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP response element binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to catecholamine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to leptin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in common myeloid progenitor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of dendritic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of dendritic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vestibular reflex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear receptor subfamily 4 group A member 3

Names: neural orphan receptor 1; orphan nuclear receptor TEC; translocated in extraskeletal chondrosarcoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001307989.2 → NP_001294918.1 nuclear receptor subfamily 4 group A member 3 isoform 2

See identical proteins and their annotated locations for NP_001294918.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL683893

UniProtKB/Swiss-Prot

Q9QZB6

Conserved Domains (1) summary

cd06969
Location:291 → 365

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
NM_015743.3 → NP_056558.1 nuclear receptor subfamily 4 group A member 3 isoform 1

See identical proteins and their annotated locations for NP_056558.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI606940, AL683893, BC038520, BC068150

Consensus CDS

CCDS18163.1

UniProtKB/Swiss-Prot

Q9QZB5, Q9QZB6

UniProtKB/TrEMBL

A0A6F8X1J9, A2VCP5

Related

ENSMUSP00000030025.4, ENSMUST00000030025.10

Conserved Domains (2) summary

cd06969
Location:291 → 365

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:397 → 627

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

48045098..48086446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537656.5 → XP_006537719.1 nuclear receptor subfamily 4 group A member 3 isoform X1

See identical proteins and their annotated locations for XP_006537719.1

UniProtKB/Swiss-Prot

Q9QZB5, Q9QZB6

UniProtKB/TrEMBL

A0A6F8X1J9, A2VCP5

Conserved Domains (2) summary

cd06969
Location:291 → 365

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:397 → 627

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_006537657.5 → XP_006537720.1 nuclear receptor subfamily 4 group A member 3 isoform X1

See identical proteins and their annotated locations for XP_006537720.1

UniProtKB/Swiss-Prot

Q9QZB5, Q9QZB6

UniProtKB/TrEMBL

A0A6F8X1J9, A2VCP5

Conserved Domains (2) summary

cd06969
Location:291 → 365

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:397 → 627

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_006537658.2 → XP_006537721.1 nuclear receptor subfamily 4 group A member 3 isoform X1

See identical proteins and their annotated locations for XP_006537721.1

UniProtKB/Swiss-Prot

Q9QZB5, Q9QZB6

UniProtKB/TrEMBL

A0A6F8X1J9, A2VCP5

Related

ENSMUSP00000121455.2, ENSMUST00000153369.2

Conserved Domains (2) summary

cd06969
Location:291 → 365

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:397 → 627

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_030253308.2 → XP_030109168.1 nuclear receptor subfamily 4 group A member 3 isoform X1

UniProtKB/Swiss-Prot

Q9QZB5, Q9QZB6

UniProtKB/TrEMBL

A0A6F8X1J9, A2VCP5

Conserved Domains (2) summary

cd06969
Location:291 → 365

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

cl11397
Location:397 → 627

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators