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    Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18105, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nqo2provided by MGI
    Official Full Name
    N-ribosyldihydronicotinamide quinone reductase 2provided by MGI
    Primary source
    MGI:MGI:104513
    See related
    Ensembl:ENSMUSG00000046949 AllianceGenome:MGI:104513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ox2; NMO2; Nmor2
    Summary
    Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in adenohypophysis. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 9.5), placenta adult (RPKM 5.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A3.3; 13 14.01 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34148642..34172448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33964655..33988465)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6c Neighboring gene STARR-seq mESC enhancer starr_34132 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene RIKEN cDNA 1110046J04 gene Neighboring gene STARR-positive B cell enhancer ABC_E2403 Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 1 Neighboring gene biphenyl hydrolase like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Celli CM, et al. Biochem Pharmacol, 2006 Jul 28. PMID 16765324
    2. Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3. Mailliet F, et al. FEBS Lett, 2004 Dec 3. PMID 15581627
    3. Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis. Iskander K, et al. Cancer Res, 2004 Sep 1. PMID 15342368
    4. Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2. Cassagnes LE, et al. Free Radic Biol Med, 2018 May 20. PMID 29526807
    5. NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease. Xu J, et al. J Biol Chem, 2013 Nov 29. PMID 24142791, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation.
      Title: Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation.
    2. these data suggest that the overexpression of QR2 in brain cells in the presence of catechol quinones might lead to reactive oxygen species-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals
      Title: Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.
    3. NQO2 stabilization of C/EBPalpha was independent of NQO1, even though both interacted with the same C/EBPa domain.
      Title: NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease.
    4. Melatonin, acting at least partially via MT2 receptors, can regulate the redox status of quinone reductase II inhibited preadipocytes.
      Title: Role of melatonin receptor MT(2) and quinone reductase II in the regulation of the redox status of 3T3-L1 preadipocytes in vitro.
    5. These data establish dihydronicotinamide riboside:quinone reductase 2 (NQO2) as part of the MT3 binding site.
      Title: Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3.
    6. role for NQO2 in protection against myelogenous hyperplasia and in metabolic activation of menadione, leading to hepatic toxicity
      Title: Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity.
    7. NQO1 and NQO2 are endogenous factors in the regulation of immune response and autoimmunity
      Title: NQO1 and NQO2 regulation of humoral immunity and autoimmunity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dihydronicotinamide riboside quinone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables melatonin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables resveratrol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in quinone catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosyldihydronicotinamide dehydrogenase [quinone]
    Names
    NAD(P)H dehydrogenase, quinone 2
    NAD(P)H menadione oxidoreductase 2, dioxin inducible
    NRH dehydrogenase [quinone] 2
    NRH: quinone oxidoreductase
    NRH:quinone oxidoreductase 2
    QR2
    quinone reductase 2
    ribosyldihydronicotinamide dehydrogenase
    NP_001156711.1
    NP_001156713.1
    NP_001156714.1
    NP_001413070.1
    NP_001413071.1
    NP_001413086.1
    NP_001413090.1
    NP_001413091.1
    NP_001413092.1
    NP_001413093.1
    NP_001413095.1
    NP_001413096.1
    NP_001413102.1
    NP_001413103.1
    NP_001413104.1
    NP_001413105.1
    NP_001413107.1
    NP_001413109.1
    NP_064678.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163239.1 → NP_001156711.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

      See identical proteins and their annotated locations for NP_001156711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC161461, AK008465
      Consensus CDS
      CCDS88437.1
      UniProtKB/TrEMBL
      A0A1Y7VL95
      Related
      ENSMUSP00000152068.2, ENSMUST00000220844.2
      Conserved Domains (1) summary
      pfam02525
      Location:18 → 168
      Flavodoxin_2; Flavodoxin-like fold

    2. NM_001163241.2 → NP_001156713.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_001156713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC161461
      Consensus CDS
      CCDS26442.1
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
      Related
      ENSMUSP00000053809.8, ENSMUST00000058978.9
      Conserved Domains (1) summary
      COG2249
      Location:4 → 215
      MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]

    3. NM_001163242.2 → NP_001156714.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_001156714.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC161461
      Consensus CDS
      CCDS26442.1
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
      Related
      ENSMUSP00000152294.2, ENSMUST00000222740.2
      Conserved Domains (1) summary
      COG2249
      Location:4 → 215
      MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]

    4. NM_001426141.1 → NP_001413070.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/Swiss-Prot
      Q9JI75

    5. NM_001426142.1 → NP_001413071.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/Swiss-Prot
      Q9JI75

    6. NM_001426157.1 → NP_001413086.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161461

    7. NM_001426161.1 → NP_001413090.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161461

    8. NM_001426162.1 → NP_001413091.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161461

    9. NM_001426163.1 → NP_001413092.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161461

    10. NM_001426164.1 → NP_001413093.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161461

    11. NM_001426166.1 → NP_001413095.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC161461

    12. NM_001426167.1 → NP_001413096.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC161461

    13. NM_001426173.1 → NP_001413102.1  ribosyldihydronicotinamide dehydrogenase [quinone] isofom 7

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/TrEMBL
      A0A1Y7VL95

    14. NM_001426174.1 → NP_001413103.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/TrEMBL
      A0A1Y7VL95

    15. NM_001426175.1 → NP_001413104.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC161461

    16. NM_001426176.1 → NP_001413105.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC161461

    17. NM_001426178.1 → NP_001413107.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC161461

    18. NM_001426180.1 → NP_001413109.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC161461

    19. NM_020282.4 → NP_064678.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_064678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC161461
      Consensus CDS
      CCDS26442.1
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
      Related
      ENSMUSP00000021843.6, ENSMUST00000021843.13
      Conserved Domains (1) summary
      COG2249
      Location:4 → 215
      MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      34148642..34172448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI75.3 GenPept UniProtKB/Swiss-Prot:Q9JI75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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