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    Nktr natural killer tumor recognition sequence [ Mus musculus (house mouse) ]

    Gene ID: 18087, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nktrprovided by MGI
    Official Full Name
    natural killer tumor recognition sequenceprovided by MGI
    Primary source
    MGI:MGI:97346
    See related
    Ensembl:ENSMUSG00000032525 AllianceGenome:MGI:97346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D9Wsu172e; 5330401F18Rik
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in extraembryonic component. Orthologous to human NKTR (natural killer cell triggering receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 21.4), CNS E14 (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F4; 9 72.57 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121542244..121585908)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121713881..121756842)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121591571-121591680 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene STARR-positive B cell enhancer mm9_chr9:121606658-121606959 Neighboring gene STARR-positive B cell enhancer ABC_E11426 Neighboring gene STARR-positive B cell enhancer ABC_E1400 Neighboring gene STARR-positive B cell enhancer ABC_E10593 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 2 Neighboring gene RIKEN cDNA E530011L22 gene Neighboring gene STARR-positive B cell enhancer ABC_E6812 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene kelch-like 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse Nktr gene and promoter. Simons-Evelyn M, et al. Genomics, 1997 Feb 15. PMID 9070924
    2. A cyclophilin-related protein involved in the function of natural killer cells. Anderson SK, et al. Proc Natl Acad Sci U S A, 1993 Jan 15. PMID 8421688, Free PMC Article
    3. Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor. Hashimoto H, et al. Genomics, 1999 May 15. PMID 10331949
    4. Genetic structure and chromosomal mapping of MyD88. Hardiman G, et al. Genomics, 1997 Oct 15. PMID 9344657
    5. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. Young HA, et al. Genomics, 1993 May. PMID 8314596

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NK-tumor recognition protein
    Names
    NK-TR protein
    PPIase
    cyclophilin-related protein
    natural killer tumor recognition protein
    natural-killer cells cyclophilin-related protein
    peptidyl-prolyl cis-trans isomerase NKTR
    NP_035048.3
    XP_006512041.1
    XP_011241241.2
    XP_030099969.1
    XP_030099970.1
    XP_030099972.1
    XP_030099973.1
    XP_030099974.1
    XP_030099975.1
    XP_030099976.1
    XP_030099979.1
    XP_030099980.1
    XP_030099981.1
    XP_030099982.1
    XP_036010573.1
    XP_036010574.1
    XP_036010575.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010918.3 → NP_035048.3  NK-tumor recognition protein

      See identical proteins and their annotated locations for NP_035048.3

      Status: VALIDATED

      Source sequence(s)
      AC159810, AC165080
      Consensus CDS
      CCDS23636.1
      UniProtKB/Swiss-Prot
      F8VPR8, P30415, Q3UNH0
      Related
      ENSMUSP00000035112.6, ENSMUST00000035112.13
      Conserved Domains (1) summary
      cl00197
      Location:7 → 174
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      121542244..121585908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244109.2 → XP_030099969.1  NK-tumor recognition protein isoform X1

      Conserved Domains (1) summary
      cl00197
      Location:109 → 276
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    2. XM_011242939.4 → XP_011241241.2  NK-tumor recognition protein isoform X2

      Conserved Domains (1) summary
      cl00197
      Location:109 → 276
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    3. XM_030244110.2 → XP_030099970.1  NK-tumor recognition protein isoform X4

      Conserved Domains (1) summary
      cl00197
      Location:109 → 240
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    4. XM_036154680.1 → XP_036010573.1  NK-tumor recognition protein isoform X3

      Conserved Domains (1) summary
      cl00197
      Location:109 → 276
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    5. XM_030244122.2 → XP_030099982.1  NK-tumor recognition protein isoform X10

      Conserved Domains (1) summary
      cl00197
      Location:130 → 220
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    6. XM_030244120.2 → XP_030099980.1  NK-tumor recognition protein isoform X7

    7. XM_030244114.2 → XP_030099974.1  NK-tumor recognition protein isoform X5

      Conserved Domains (1) summary
      pfam00160
      Location:1 → 63
      Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

    8. XM_030244112.2 → XP_030099972.1  NK-tumor recognition protein isoform X5

      Conserved Domains (1) summary
      pfam00160
      Location:1 → 63
      Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

    9. XM_036154681.1 → XP_036010574.1  NK-tumor recognition protein isoform X7

    10. XM_030244116.2 → XP_030099976.1  NK-tumor recognition protein isoform X6

      Conserved Domains (1) summary
      pfam00160
      Location:1 → 63
      Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

    11. XM_006511978.3 → XP_006512041.1  NK-tumor recognition protein isoform X5

      See identical proteins and their annotated locations for XP_006512041.1

      Conserved Domains (1) summary
      pfam00160
      Location:1 → 63
      Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

    12. XM_030244113.2 → XP_030099973.1  NK-tumor recognition protein isoform X5

      Conserved Domains (1) summary
      pfam00160
      Location:1 → 63
      Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

    13. XM_030244115.2 → XP_030099975.1  NK-tumor recognition protein isoform X5

      Conserved Domains (1) summary
      pfam00160
      Location:1 → 63
      Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

    14. XM_030244119.2 → XP_030099979.1  NK-tumor recognition protein isoform X7

    15. XM_030244121.2 → XP_030099981.1  NK-tumor recognition protein isoform X8

    16. XM_036154682.1 → XP_036010575.1  NK-tumor recognition protein isoform X9

    RNA

    1. XR_003947811.2 RNA Sequence

    2. XR_004935337.1 RNA Sequence

    3. XR_003947812.2 RNA Sequence

    4. XR_871176.2 RNA Sequence

    5. XR_871177.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30415.4 GenPept UniProtKB/Swiss-Prot:P30415

    Gene LinkOut

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