Nhlh1 nescient helix loop helix 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nhlh1provided by MGI
Official Full Name: nescient helix loop helix 1provided by MGI
Primary source: MGI:MGI:98481
See related: Ensembl:ENSMUSG00000051251 AllianceGenome:MGI:98481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hen1; Nscl; Tal2; bHLHa35
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; sensory organ; and skin. Orthologous to human NHLH1 (nescient helix-loop-helix 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 11.7), CNS E14 (RPKM 7.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.54 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171879859..171885163, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172052292..172057596, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice.
Title: Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice.
These results demonstrate that NeuroD1 is an upstream regulator of the NSCL1 gene but not the NSCL2 gene in mice.
Title: NeuroD1 is an upstream regulator of NSCL1.
Insm1 and Nhlh1/NSCL1 are novel HH targets induced by Shh treatment in cultured cerebellar granule cell progenitors.
Title: An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma.
The mouse homolog of HEN1 is expressed specifically in testis and methylates 3' termini of Piwi-interacting RNAs in vitro.
Title: The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs.
We conclude that NSCL-1/2 maintain migration and survival of cells in the migratory stream to the cerebellum.
Title: NSCL-1 and -2 control the formation of precerebellar nuclei by orchestrating the migration of neuronal precursor cells.
Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice.
Title: Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice.
Data show that NSCL-1 and -2, together with additional cofactors, directly control transcription of the necdin gene.
Title: NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression.
expression in the olfactory epithelium (OE) and the vomeronasal organ (VNO) during development; may function during development rather than in the adult stage
Title: Expression of bHLH transcription factors NSCL1 and NSCL2 in the mouse olfactory system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Nhlh1 (e-PCR), detects polymorphism
- UniSTS:144015

Nhlh1 (e-PCR), detects polymorphism
- UniSTS:144016

Nhlh1 (e-PCR), detects polymorphism
- UniSTS:144017

Nhlh1 (e-PCR), detects polymorphism
- UniSTS:545968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: helix-loop-helix protein 1

Names: HELIX-LOOP-HELIX PROTEIN 1 (HEN1) (NSCL); HEN-1; NSCL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.