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    Nfatc2ip nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 18020, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nfatc2ipprovided by MGI
    Official Full Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1329015
    See related
    Ensembl:ENSMUSG00000030722 AllianceGenome:MGI:1329015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIP45; D7Ertd304e
    Summary
    Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early embryo; eye; genitourinary system; and limb. Orthologous to human NFATC2IP (nuclear factor of activated T cells 2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.5), thymus adult (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 69.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125982025..125995909, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126382853..126396796, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133513013-133513200 Neighboring gene microRNA 7058 Neighboring gene linker for activation of T cells Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133521004-133521187 Neighboring gene SPNS lysolipid transporter 1, lysophospholipid Neighboring gene STARR-seq mESC enhancer starr_20144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133540343-133540526 Neighboring gene STARR-positive B cell enhancer ABC_E8208 Neighboring gene STARR-positive B cell enhancer ABC_E9706 Neighboring gene CD19 antigen Neighboring gene STARR-positive B cell enhancer ABC_E9707 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NIP45 controls the magnitude of the type 2 T helper cell response. Fathman JW, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133688, Free PMC Article
    2. Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization. Hashiguchi K, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159618
    3. NIP45 negatively regulates RANK ligand induced osteoclast differentiation. Shanmugarajan S, et al. J Cell Biochem, 2012 Apr. PMID 22105856, Free PMC Article
    4. Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2). Koch S, et al. Sci Rep, 2019 Oct 30. PMID 31666531, Free PMC Article
    5. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. Bryce PJ, et al. Int Immunol, 2006 Jan. PMID 16352630

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
      Title: Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
    2. Under standard, non-stressful conditions, FLAG-mNip45 diffusely distributed in the nucleus.
      Title: Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization.
    3. results indicate that RANKL signaling down regulates NIP45 expression and that NIP45 is a negative regulator of osteoclast differentiation
      Title: NIP45 negatively regulates RANK ligand induced osteoclast differentiation.
    4. This finding highlights a possible role of the RENi proteins in the modulation of Ubc9-mediated poly-SUMO formation.
      Title: Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45.
    5. NIP45 promotes robust cytokine expression in vivo, which is required for the efficient handling of parasites, acting as a molecular rheostat serving to amplify the type-2 immune response.
      Title: NIP45 controls the magnitude of the type 2 T helper cell response.
    6. Data report a role for arginine methylation of NIP45 in regulating cytokine gene transcription in the T helper lymphocyte.
      Title: Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes.
    7. TRAF1 limit the induction of Th2 responses by decreasing NIP45 concentration to the nucleus down-regulating the expression of NIP45-dependent IL-4 gene transcription.
      Title: TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130564

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NFATC2-interacting protein
    Names
    45 kDa NF-AT-interacting protein
    45 kDa NFAT-interacting protein
    nuclear factor of activated T-cells, cytoplasmic 2-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412712.1 → NP_001399641.1  NFATC2-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125322

    2. NM_001412713.1 → NP_001399642.1  NFATC2-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125322

    3. NM_010900.4 → NP_035030.2  NFATC2-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_035030.2

      Status: VALIDATED

      Source sequence(s)
      AC125322
      Consensus CDS
      CCDS21827.1
      UniProtKB/Swiss-Prot
      O09130, Q8CDG2, Q9CVY5
      Related
      ENSMUSP00000075094.5, ENSMUST00000075671.5
      Conserved Domains (2) summary
      smart00213
      Location:258 → 327
      UBQ; Ubiquitin homologues
      cl00155
      Location:341 → 410
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      125982025..125995909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09130.1 GenPept UniProtKB/Swiss-Prot:O09130

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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