Ndn necdin, MAGE family member [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndnprovided by MGI
Official Full Name: necdin, MAGE family memberprovided by MGI
Primary source: MGI:MGI:97290
See related: Ensembl:ENSMUSG00000033585 AllianceGenome:MGI:97290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Peg6
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; gamma-tubulin binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including nervous system development; neurotrophin TRK receptor signaling pathway; and regulation of transcription, DNA-templated. Located in several cellular components, including centrosome; cytosol; and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to human NDN (necdin, MAGE family member). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 7 34.36 cM; 7 C

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (61998025..61999676)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (62348277..62349928)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and characterization of Necdin as a target for the Cockayne syndrome B protein in promoting neuronal differentiation and maintenance.
Title: Identification and characterization of Necdin as a target for the Cockayne syndrome B protein in promoting neuronal differentiation and maintenance.
Necdin, one of the important pathway proteins in the regulation of osteosarcoma progression by microRNA-200c.
Title: Necdin, one of the important pathway proteins in the regulation of osteosarcoma progression by microRNA-200c.
Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.
Title: Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.
The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
Title: The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery.
Title: Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery.
SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.
Title: SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.
Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin-knockout pups.
Title: Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome.
The Necdin expression was further associated with suppression of both cell proliferation and death in osteoblasts.
Title: Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
Data reveal that necdin promotes mitochondrial biogenesis through stabilization of endogenous PGC-1alpha to exert neuroprotection against mitochondrial insults.
Title: Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
Our data suggest that necdin suppresses PIAS1 both by inhibiting SUMO E3 ligase activity and by promoting ubiquitin-dependent degradation.
Title: Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC85624P1 (e-PCR)
- UniSTS:273481

AI528698 (e-PCR)
- UniSTS:163420

Ndn (e-PCR), detects polymorphism
- UniSTS:143996

Ndn (e-PCR), detects polymorphism
- UniSTS:143997

Ndn (e-PCR), detects polymorphism
- UniSTS:547459

Ndn (e-PCR), detects polymorphism
- UniSTS:547460

NoName (e-PCR)
- UniSTS:235678

Ndn (e-PCR), detects polymorphism
- UniSTS:532148

Ndn (e-PCR), detects polymorphism
- UniSTS:507080

PMC197148P1 (e-PCR)
- UniSTS:271845

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal-level homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: necdin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.