Ncoa1 nuclear receptor coactivator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncoa1provided by MGI
Official Full Name: nuclear receptor coactivator 1provided by MGI
Primary source: MGI:MGI:1276523
See related: Ensembl:ENSMUSG00000020647 AllianceGenome:MGI:1276523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SRC1; NRC-1; SRC-1; SRC-a; KAT13A; NCoA-1; mNRC-1; bHLHe74
Summary: Enables DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including histone H4 acetylation; positive regulation of transcription from RNA polymerase II promoter by galactose; and regulation of cellular response to drug. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; labyrinthine layer morphogenesis; and regulation of thyroid hormone mediated signaling pathway. Predicted to be located in several cellular components, including chromatin; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Used to study obesity and thyroid hormone resistance syndrome. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 11.3), cerebellum adult (RPKM 11.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 2.05 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (4297362..4569452, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (4247362..4477206, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.
Title: Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.
The NCOA1-CBP-NF-kappaB transcriptional complex induces inflammation response and triggers endotoxin-induced myocardial dysfunction.
Title: The NCOA1-CBP-NF-κB transcriptional complex induces inflammation response and triggers endotoxin-induced myocardial dysfunction.
SRC-1 Deficiency Increases Susceptibility of Mice to Depressive-Like Behavior After Exposure to CUMS.
Title: SRC-1 Deficiency Increases Susceptibility of Mice to Depressive-Like Behavior After Exposure to CUMS.
Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterusdagger.
Title: Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†.
Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.
Title: Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.
required in the hippocampus for consolidation and reconsolidation of contextual fear memory
Title: Inhibition of steroid receptor coactivator-1 in the hippocampus impairs the consolidation and reconsolidation of contextual fear memory in mice.
SRC-1 modulates the function of hypothalamic Pomc neurons
Title: Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.
Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity.
Title: Sumoylation of RORγt regulates T(H)17 differentiation and thymocyte development.
Although the SRC-1 expression in female mice was lower than that in males under normal conditions, its expression in females was more dominant after spinal cord injury. The expression of Profilin-1 in both sexes increased first, and then decreased at 3 days after injury. However, there was a second increase in females at 7 days after injury.
Title: Sex differences of steroid receptor coactivator-1 expression after spinal cord injury in mice.
SRC-1 can impact osteoblast function in an estrogen receptor-independent manner.
Title: Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (8) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S11348 (e-PCR)
- UniSTS:264992

WI-20578 (e-PCR)
- UniSTS:3127

RH80592 (e-PCR)
- UniSTS:84302

BE457733 (e-PCR)
- UniSTS:208772

PMC15526P1 (e-PCR)
- UniSTS:271334

PMC15526P2 (e-PCR)
- UniSTS:271335

NoName (e-PCR)
- UniSTS:236799

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in male mating behavior	ISO Inferred from Sequence Orthology more info
involved_in peroxisome proliferator activated receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adipose tissue development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of female receptivity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by galactose	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to insulin stimulus	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of thyroid hormone mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	EXP Inferred from Experiment more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor coactivator 1

Names: nuclear receptor coactivator protein 1; steroid receptor coactivator 1

NP_001395526.1

EC 2.3.1.48

NP_001395527.1

EC 2.3.1.48

NP_001395528.1

EC 2.3.1.48

NP_001395529.1

EC 2.3.1.48

NP_001395530.1

EC 2.3.1.48

NP_001395531.1

EC 2.3.1.48

NP_001395532.1

EC 2.3.1.48

NP_001395533.1

EC 2.3.1.48

NP_001395534.1

EC 2.3.1.48

NP_001395535.1

EC 2.3.1.48

NP_035011.1

EC 2.3.1.48

XP_006515069.1

EC 2.3.1.48

XP_006515070.1

EC 2.3.1.48

XP_030102457.1

EC 2.3.1.48

XP_036013113.1

EC 2.3.1.48

XP_036013116.1

EC 2.3.1.48

XP_036013117.1

EC 2.3.1.48

XP_036013118.1

EC 2.3.1.48

XP_036013119.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001408597.1 → NP_001395526.1 nuclear receptor coactivator 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_001408598.1 → NP_001395527.1 nuclear receptor coactivator 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_001408599.1 → NP_001395528.1 nuclear receptor coactivator 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_001408600.1 → NP_001395529.1 nuclear receptor coactivator 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_001408601.1 → NP_001395530.1 nuclear receptor coactivator 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_001408602.1 → NP_001395531.1 nuclear receptor coactivator 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254

UniProtKB/Swiss-Prot

P70365, P70366, Q61202, Q66JL7, Q8CBI9
NM_001408603.1 → NP_001395532.1 nuclear receptor coactivator 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_001408604.1 → NP_001395533.1 nuclear receptor coactivator 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_001408605.1 → NP_001395534.1 nuclear receptor coactivator 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254

Related

ENSMUSP00000151716.2, ENSMUST00000217794.2
NM_001408606.1 → NP_001395535.1 nuclear receptor coactivator 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254
NM_010881.3 → NP_035011.1 nuclear receptor coactivator 1 isoform 1

See identical proteins and their annotated locations for NP_035011.1

Status: VALIDATED

Source sequence(s)

AC162932, AC241534, CU041254

Consensus CDS

CCDS25789.1

UniProtKB/Swiss-Prot

P70365

Related

ENSMUSP00000082971.4, ENSMUST00000085814.5

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:980 → 1366

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1155 → 1211

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:930 → 975

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 712

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:747 → 824

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

4297362..4569452 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157220.1 → XP_036013113.1 nuclear receptor coactivator 1 isoform X1

UniProtKB/Swiss-Prot

P70365, P70366, Q61202, Q66JL7, Q8CBI9

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:980 → 1366

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1155 → 1211

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:930 → 975

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 712

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:747 → 824

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_036157223.1 → XP_036013116.1 nuclear receptor coactivator 1 isoform X4

Conserved Domains (5) summary

pfam07469
Location:775 → 831

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:550 → 595

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:256 → 332

SRC-1; Steroid receptor coactivator

pfam16279
Location:367 → 444

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:89 → 211

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_006515007.5 → XP_006515070.1 nuclear receptor coactivator 1 isoform X1

See identical proteins and their annotated locations for XP_006515070.1

UniProtKB/Swiss-Prot

P70365, P70366, Q61202, Q66JL7, Q8CBI9

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:980 → 1366

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1155 → 1211

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:930 → 975

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 712

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:747 → 824

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_036157224.1 → XP_036013117.1 nuclear receptor coactivator 1 isoform X4

Conserved Domains (5) summary

pfam07469
Location:775 → 831

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:550 → 595

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:256 → 332

SRC-1; Steroid receptor coactivator

pfam16279
Location:367 → 444

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:89 → 211

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_006515006.5 → XP_006515069.1 nuclear receptor coactivator 1 isoform X1

See identical proteins and their annotated locations for XP_006515069.1

UniProtKB/Swiss-Prot

P70365, P70366, Q61202, Q66JL7, Q8CBI9

Related

ENSMUSP00000151358.2, ENSMUST00000220434.2

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam09606
Location:980 → 1366

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

pfam07469
Location:1155 → 1211

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:930 → 975

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:636 → 712

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:747 → 824

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_036157225.1 → XP_036013118.1 nuclear receptor coactivator 1 isoform X5

Conserved Domains (6) summary

pfam09606
Location:600 → 986

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam07469
Location:775 → 831

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:550 → 595

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:256 → 332

SRC-1; Steroid receptor coactivator

pfam16279
Location:367 → 444

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:89 → 211

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_036157226.1 → XP_036013119.1 nuclear receptor coactivator 1 isoform X5

Conserved Domains (6) summary

pfam09606
Location:600 → 986

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam07469
Location:775 → 831

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:550 → 595

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:256 → 332

SRC-1; Steroid receptor coactivator

pfam16279
Location:367 → 444

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:89 → 211

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_030246597.2 → XP_030102457.1 nuclear receptor coactivator 1 isoform X2

Conserved Domains (9) summary

cd00130
Location:120 → 213

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08815
Location:930 → 976

Nuc_rec_co-act; Nuclear receptor coactivator

pfam09606
Location:980 → 1366

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam07469
Location:1155 → 1210

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:636 → 712

SRC-1; Steroid receptor coactivator

pfam14598
Location:260 → 370

PAS_11; PAS domain

pfam16279
Location:747 → 824

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:469 → 591

NCOA_u2; Unstructured region on nuclear receptor coactivator protein

cd18948
Location:27 → 87

bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins