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    Nbl1 NBL1, DAN family BMP antagonist [ Mus musculus (house mouse) ]

    Gene ID: 17965, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nbl1provided by MGI
    Official Full Name
    NBL1, DAN family BMP antagonistprovided by MGI
    Primary source
    MGI:MGI:104591
    See related
    Ensembl:ENSMUSG00000041120 AllianceGenome:MGI:104591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAN; NO3; Dana; D4H1S1733E
    Summary
    Enables BMP binding activity and morphogen activity. Involved in several processes, including determination of dorsal identity; negative regulation of monocyte chemotaxis; and sequestering of BMP in extracellular matrix. Acts upstream of or within negative regulation of BMP signaling pathway; neuron projection morphogenesis; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain ventricular layer; embryo mesenchyme; limb; and nose. Orthologous to several human genes including MICOS10-NBL1 (MICOS10-NBL1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 159.8), lung adult (RPKM 140.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 70.57 cM; 4 D3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138809602..138820437, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139082291..139093126, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene predicted gene, 33214 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4693 Neighboring gene mitochondrial contact site and cristae organizing system subunit 10 Neighboring gene STARR-positive B cell enhancer ABC_E9606 Neighboring gene predicted gene, 33304 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma. Ohtori S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033178
    2. Expression of the BMP antagonist Dan during murine forebrain development. Kim AS, et al. Brain Res Dev Brain Res, 2003 Oct 10. PMID 14519502
    3. GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells. López de Maturana R, et al. Neuromolecular Med, 2007. PMID 17914181
    4. Cloning of mouse DAN cDNA and its down-regulation in transformed cells. Ozaki T, et al. Jpn J Cancer Res, 1996 Jan. PMID 8609050, Free PMC Article
    5. Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis. Shi W, et al. Am J Physiol Lung Cell Mol Physiol, 2001 May. PMID 11290528

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DAN is a novel autocrine/paracrine factor that modulates GnRH function in pituitary gonadotropes.
      Title: GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.
    2. Dan expression during murine forebrain development from embryonic day 10.5 to postnatal day 14 and found that Dan was expressed in highly specific spatiotemporal patterns.
      Title: Expression of the BMP antagonist Dan during murine forebrain development.
    3. Data using DAN-deficient mice to investigate thermal and mechanical allodynia and Fos expression in the spinal dorsal horn suggest that Dan may be a neuromodulator in inflammatory pain.
      Title: Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123430

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables BMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables morphogen activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of dorsal identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sequestering of BMP from receptor via BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sequestering of BMP in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuroblastoma suppressor of tumorigenicity 1
    Names
    N03
    neuroblastoma, suppression of tumorigenicity 1
    zinc finger protein DAN

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008675.2 → NP_032701.2  neuroblastoma suppressor of tumorigenicity 1 precursor

      See identical proteins and their annotated locations for NP_032701.2

      Status: VALIDATED

      Source sequence(s)
      AK146535
      Consensus CDS
      CCDS18839.1
      UniProtKB/Swiss-Prot
      Q499K5, Q61477
      Related
      ENSMUSP00000045608.7, ENSMUST00000042844.7
      Conserved Domains (1) summary
      pfam03045
      Location:22 → 120
      DAN; DAN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138809602..138820437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253300.1 → XP_030109160.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

      UniProtKB/Swiss-Prot
      Q499K5, Q61477
      Conserved Domains (1) summary
      pfam03045
      Location:22 → 120
      DAN; DAN domain

    2. XM_036163807.1 → XP_036019700.1  neuroblastoma suppressor of tumorigenicity 1 isoform X1

      Conserved Domains (1) summary
      pfam03045
      Location:71 → 169
      DAN; DAN domain

    3. XM_006538625.5 → XP_006538688.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

      See identical proteins and their annotated locations for XP_006538688.1

      UniProtKB/Swiss-Prot
      Q499K5, Q61477
      Conserved Domains (1) summary
      pfam03045
      Location:22 → 120
      DAN; DAN domain

    4. XM_030253299.2 → XP_030109159.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

      UniProtKB/Swiss-Prot
      Q499K5, Q61477
      Conserved Domains (1) summary
      pfam03045
      Location:22 → 120
      DAN; DAN domain

    5. XM_036163808.1 → XP_036019701.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

      UniProtKB/Swiss-Prot
      Q499K5, Q61477
      Conserved Domains (1) summary
      pfam03045
      Location:22 → 120
      DAN; DAN domain

    6. XM_030253301.2 → XP_030109161.1  neuroblastoma suppressor of tumorigenicity 1 isoform X2

      UniProtKB/Swiss-Prot
      Q499K5, Q61477
      Conserved Domains (1) summary
      pfam03045
      Location:22 → 120
      DAN; DAN domain

    7. XM_036163809.1 → XP_036019702.1  neuroblastoma suppressor of tumorigenicity 1 isoform X3

      Conserved Domains (1) summary
      pfam03045
      Location:57 → 155
      DAN; DAN domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61477.2 GenPept UniProtKB/Swiss-Prot:Q61477

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