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    Naip2 NLR family, apoptosis inhibitory protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 17948, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Naip2provided by MGI
    Official Full Name
    NLR family, apoptosis inhibitory protein 2provided by MGI
    Primary source
    MGI:MGI:1298226
    See related
    Ensembl:ENSMUSG00000078945 AllianceGenome:MGI:1298226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Birc1b; Naip-rs6
    Summary
    Predicted to enable ATP binding activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in inflammatory response; pyroptosis; and response to bacterium. Acts upstream of or within cellular response to estrogen stimulus. Part of IPAF inflammasome complex. Is expressed in several structures, including central nervous system; heart; liver; male reproductive system; and urinary system. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 11.9), colon adult (RPKM 8.3) and 12 other tissues See more
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    Genomic context

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    Location:
    13 D1; 13 53.01 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100280571..100338630, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100144063..100202122, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3095 Neighboring gene small EDRK-rich factor 1 Neighboring gene survival motor neuron 1 Neighboring gene STARR-seq mESC enhancer starr_35471 Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene NLR family, apoptosis inhibitory protein 1, related sequence 1 Neighboring gene STARR-seq mESC enhancer starr_35472 Neighboring gene STARR-seq mESC enhancer starr_35473 Neighboring gene NLR family, apoptosis inhibitory protein 5 Neighboring gene STARR-seq mESC enhancer starr_35474 Neighboring gene NLR family, apoptosis inhibitory protein 3, pseudogene 1 Neighboring gene NLR family, apoptosis inhibitory protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and the 5'genomic organization of Naip2, a candidate gene for murine Legionella resistance. Yaraghi Z, et al. Mamm Genome, 1999 Jul. PMID 10384056
    2. Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice. Zhao Y, et al. J Exp Med, 2016 May 2. PMID 27114610, Free PMC Article
    3. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Wright EK, et al. Curr Biol, 2003 Jan 8. PMID 12526741
    4. The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells. Götz R, et al. Hum Mol Genet, 2000 Oct 12. PMID 11030753
    5. The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts. Huang S, et al. Mamm Genome, 1999 Oct. PMID 10501978

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin.
      Title: NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.
    2. These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice.
      Title: Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice.
    3. activation of caspase-1 by Shigella is triggered by the rod protein MxiI that interacts with Naip2 to induce activation of the Nlrc4 inflammasome independently of the Pkcdelta kinase
      Title: Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141528

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyroptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyroptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of IPAF inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of IPAF inflammasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    baculoviral IAP repeat-containing protein 1b
    Names
    neuronal apoptosis inhibitory protein, related sequence 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126182.2 → NP_001119654.1  baculoviral IAP repeat-containing protein 1b

      See identical proteins and their annotated locations for NP_001119654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY147001, BY154503, CT030167
      Consensus CDS
      CCDS26726.1
      UniProtKB/Swiss-Prot
      A9C470, O09124, Q9QUK4, Q9R030
      UniProtKB/TrEMBL
      Q540N6, Q8CGT0
      Related
      ENSMUSP00000070827.6, ENSMUST00000067975.12
      Conserved Domains (6) summary
      smart00238
      Location:159 → 229
      BIR; Baculoviral inhibition of apoptosis protein repeat
      smart00382
      Location:507 → 644
      AAA; ATPases associated with a variety of cellular activities
      cd00022
      Location:61 → 129
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00116
      Location:1106 → 1373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1201 → 1226
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:508 → 662
      NACHT; NACHT domain

    2. NM_010872.3 → NP_035002.2  baculoviral IAP repeat-containing protein 1b

      See identical proteins and their annotated locations for NP_035002.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY147001, BY154503, CT030167
      Consensus CDS
      CCDS26726.1
      UniProtKB/Swiss-Prot
      A9C470, O09124, Q9QUK4, Q9R030
      UniProtKB/TrEMBL
      Q540N6, Q8CGT0
      Related
      ENSMUSP00000113890.2, ENSMUST00000117913.8
      Conserved Domains (6) summary
      smart00238
      Location:159 → 229
      BIR; Baculoviral inhibition of apoptosis protein repeat
      smart00382
      Location:507 → 644
      AAA; ATPases associated with a variety of cellular activities
      cd00022
      Location:61 → 129
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00116
      Location:1106 → 1373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:1201 → 1226
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:508 → 662
      NACHT; NACHT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100280571..100338630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUK4.2 GenPept UniProtKB/Swiss-Prot:Q9QUK4

    Gene LinkOut

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