Nab2 Ngfi-A binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nab2provided by MGI
Official Full Name: Ngfi-A binding protein 2provided by MGI
Primary source: MGI:MGI:107563
See related: Ensembl:ENSMUSG00000025402 AllianceGenome:MGI:107563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable identical protein binding activity and transcription coregulator activity. Acts upstream of or within several processes, including endochondral ossification; nervous system development; and regulation of epidermis development. Located in nucleus. Is expressed in future hindbrain and genitourinary system. Orthologous to human NAB2 (NGFI-A binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 34.3), thymus adult (RPKM 23.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.6 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127496787..127502572, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127660918..127666703, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development.
Title: Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development.
Study characterized sequences in NAB2 that mediate its nuclear localization and determined that the KKXK motif that aligns with the NAB1 KRXK motif is necessary for NAB2 nuclear localization, while the K(X2)R motif situated 11 residues upstream is not.
Title: Refining the nuclear localization signal within the Egr transcriptional coregulator NAB2.
These findings indicate a requirement for Nab2 in maintaining thymocyte number in male mice with age and in response to stress.
Title: Nab2 maintains thymus cellularity with aging and stress.
Data suggest that histone deacetylase inhibitors inhibit the induction of NGF1A-binding protein Nab2 by brain derived neurotrophic factor (BDNF), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32).
Title: Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2.
Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses
Title: The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma.
Helps control the fate of antigen recognition in T cells.
Title: Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.
Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
Title: Nab proteins are essential for peripheral nervous system myelination.
We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1.
Title: FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1.
NAB2 enhances IL-2 transcription by acting as a coactivator for Egr-1.NAB2 is recruited to the Egr-1 binding site of the IL-2 promoter.
Title: Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription.
repression of the endogenous Rad gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex
Title: NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nab2 (e-PCR), detects polymorphism
- UniSTS:498246

AI451907 (e-PCR)
- UniSTS:180135

RH128335 (e-PCR)
- UniSTS:211643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Schwann cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endochondral ossification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myelination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of epidermis development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NGFI-A-binding protein 2

Names: EGR-1-binding protein 2; NGFI-A binding protein 2 (EGR-1 binding protein 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122895.1 → NP_001116367.1 NGFI-A-binding protein 2 isoform 2

See identical proteins and their annotated locations for NP_001116367.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

BC045139, BY160550

Consensus CDS

CCDS48719.1

UniProtKB/TrEMBL

Q3TBL2, Q3TYF1

Related

ENSMUSP00000096761.4, ENSMUST00000099157.4

Conserved Domains (2) summary

pfam04904
Location:37 → 114

NCD1; NAB conserved region 1 (NCD1)

pfam04905
Location:235 → 364

NCD2; NAB conserved region 2 (NCD2)
NM_008668.2 → NP_032694.2 NGFI-A-binding protein 2 isoform 1

See identical proteins and their annotated locations for NP_032694.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC045139, BY160550

Consensus CDS

CCDS24247.1

UniProtKB/Swiss-Prot

Q61127, Q80VR9

UniProtKB/TrEMBL

Q3TBL2

Related

ENSMUSP00000026469.3, ENSMUST00000026469.9

Conserved Domains (2) summary

pfam04904
Location:37 → 114

NCD1; NAB conserved region 1 (NCD1)

pfam04905
Location:235 → 364

NCD2; NAB conserved region 2 (NCD2)