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    Myom1 myomesin 1 [ Mus musculus (house mouse) ]

    Gene ID: 17929, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Myom1provided by MGI
    Official Full Name
    myomesin 1provided by MGI
    Primary source
    MGI:MGI:1341430
    See related
    Ensembl:ENSMUSG00000024049 AllianceGenome:MGI:1341430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D430047A17Rik
    Summary
    Enables protein homodimerization activity. Acts upstream of or within muscle contraction. Located in M band. Is expressed in several structures, including alimentary system; cardiovascular system; musculature; respiratory system; and skeleton. Orthologous to human MYOM1 (myomesin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 44.7), bladder adult (RPKM 18.0) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.3; 17 41.87 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71326455..71433851)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71003332..71126856)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3214 Neighboring gene myosin, light chain 12A, regulatory, non-sarcomeric Neighboring gene predicted gene, 53974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:71533967-71534150 Neighboring gene STARR-positive B cell enhancer ABC_E4223 Neighboring gene lipin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71564522-71564823 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71573946-71574247 Neighboring gene elastin microfibril interfacer 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skelemin association with αIIbβ3 integrin: a structural model. Gorbatyuk V, et al. Biochemistry, 2014 Nov 4. PMID 25224262, Free PMC Article
    2. Identification of an interaction between the m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cells. Reddy KB, et al. J Biol Chem, 1998 Dec 25. PMID 9857037
    3. Skelemin, a cytoskeletal M-disc periphery protein, contains motifs of adhesion/recognition and intermediate filament proteins. Price MG, et al. J Biol Chem, 1993 Oct 15. PMID 8408035
    4. Nuclear localization of Myomesin-1: possible functions. Reddy KB, et al. J Muscle Res Cell Motil, 2008. PMID 18521710
    5. M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression. Steiner F, et al. Genomics, 1999 Feb 15. PMID 10036188

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myomesin-1
    Names
    myomesin family member 1
    skelemin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083934.1 → NP_001077403.1  myomesin-1 isoform 2

      See identical proteins and their annotated locations for NP_001077403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC154187, AC154218, AC154717
      Consensus CDS
      CCDS50176.1
      UniProtKB/TrEMBL
      Z4YJF5
      Related
      ENSMUSP00000136266.2, ENSMUST00000179759.3
      Conserved Domains (3) summary
      smart00409
      Location:264 → 350
      IG; Immunoglobulin
      cd00063
      Location:618 → 711
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:1456 → 1547
      Ig; Immunoglobulin domain

    2. NM_010867.2 → NP_034997.2  myomesin-1 isoform 1

      See identical proteins and their annotated locations for NP_034997.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC154187, AC154218, AC154717, AJ012072, BY790868, CA460156
      Consensus CDS
      CCDS37685.1
      UniProtKB/Swiss-Prot
      Q546T8, Q62234, Q6PAC0
      UniProtKB/TrEMBL
      Z4YJF5
      Related
      ENSMUSP00000072945.6, ENSMUST00000073211.13
      Conserved Domains (3) summary
      smart00410
      Location:264 → 350
      IG_like; Immunoglobulin like
      cd00063
      Location:618 → 711
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:1554 → 1645
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      71326455..71433851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523788.5 → XP_006523851.1  myomesin-1 isoform X3

      Conserved Domains (3) summary
      smart00409
      Location:264 → 350
      IG; Immunoglobulin
      cd00063
      Location:618 → 711
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:397 → 464
      Ig; Immunoglobulin domain

    2. XM_006523787.5 → XP_006523850.1  myomesin-1 isoform X2

      Conserved Domains (3) summary
      smart00409
      Location:264 → 350
      IG; Immunoglobulin
      cd00063
      Location:618 → 711
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:397 → 464
      Ig; Immunoglobulin domain

    3. XM_036160365.1 → XP_036016258.1  myomesin-1 isoform X1

      Conserved Domains (3) summary
      cd00063
      Location:237 → 326
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:770 → 773
      Ig; Ig strand A [structural motif]
      cl11960
      Location:770 → 861
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62234.2 GenPept UniProtKB/Swiss-Prot:Q62234

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