Myo1f myosin IF [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo1fprovided by MGI
Official Full Name: myosin IFprovided by MGI
Primary source: MGI:MGI:107711
See related: Ensembl:ENSMUSG00000024300 AllianceGenome:MGI:107711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C330006B10Rik
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; neutrophil degranulation; and positive regulation of cell migration. Located in cortical actin cytoskeleton. Part of filamentous actin. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human MYO1F (myosin IF). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 12.7), lung adult (RPKM 7.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (33774681..33826738)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33555707..33607764)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo1f has an essential role in gammadeltaT intraepithelial lymphocyte adhesion and migration.
Title: Myo1f has an essential role in γδT intraepithelial lymphocyte adhesion and migration.
Study demonstrated that intercellular adhesion is mediated by integrin-alphaVbeta3 and relies in the presence of the unconventional class I myosin 1F (Myo1F). Intercellular adhesion mediated by alphaVbeta3 stimulates M1-like phenotype in macrophages through hyperactivation of STAT1 and STAT3 downstream of ILK/Akt/mTOR signaling.
Title: Myosin 1F Regulates M1-Polarization by Stimulating Intercellular Adhesion in Macrophages.
evidence for an important role of Myo1f in neutrophil trafficking during inflammation by specifically regulating neutrophil extravasation and migration in 3D environments.
Title: Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation.
Myo1f-deficient mice exhibited abnormally increased adhesion and reduced motility, resulting from augmented exocytosis of beta2 integrin-containing granules; Myo1f directs immune cell motility and innate host defense against infection
Title: Modulation of cell adhesion and motility in the immune system by Myo1f.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X97650 (e-PCR)
- UniSTS:181011

Myo1f (e-PCR), detects polymorphism
- UniSTS:463418

D17Dcr4 (e-PCR), detects polymorphism
- UniSTS:507530

D17Mit16 (e-PCR), detects polymorphism
- UniSTS:116475

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	IDA Inferred from Direct Assay more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: unconventional myosin-If

Names: myosin-1F-like protein; myosin-If

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053214.2 → NP_444444.2 unconventional myosin-If

See identical proteins and their annotated locations for NP_444444.2

Status: VALIDATED

Source sequence(s)

AK036840, AK158333, BE691075, BY196585, CT030734, CT033847

Consensus CDS

CCDS37567.1

UniProtKB/TrEMBL

Q811E7, Q8CG29

Related

ENSMUSP00000084887.6, ENSMUST00000087605.13

Conserved Domains (4) summary

cd11827
Location:1045 → 1097

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

smart00242
Location:12 → 690

MYSc; Myosin. Large ATPases

cd01378
Location:31 → 677

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:717 → 897

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding