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    Myef2 myelin basic protein expression factor 2, repressor [ Mus musculus (house mouse) ]

    Gene ID: 17876, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Myef2provided by MGI
    Official Full Name
    myelin basic protein expression factor 2, repressorprovided by MGI
    Primary source
    MGI:MGI:104592
    See related
    Ensembl:ENSMUSG00000027201 AllianceGenome:MGI:104592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1341; 9430071B01
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of post-mRNA release spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; liver; sensory organ; thymus; and vertebral axis musculature. Orthologous to human MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 22.6), CNS E14 (RPKM 21.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 61.16 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (124922894..124966727, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125080975..125123660, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5974 Neighboring gene predicted gene, 39920 Neighboring gene predicted gene, 52495 Neighboring gene STARR-seq mESC enhancer starr_05578 Neighboring gene STARR-seq mESC enhancer starr_05579 Neighboring gene STARR-seq mESC enhancer starr_05581 Neighboring gene solute carrier family 24, member 5 Neighboring gene STARR-seq mESC enhancer starr_05583 Neighboring gene predicted gene, 22352 Neighboring gene predicted gene, 46759 Neighboring gene cortexin 2 Neighboring gene solute carrier family 12, member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:125014961-125015261 Neighboring gene predicted gene, 46760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence for inhibition of MyEF-2 binding to MBP promoter by MEF-1/Pur alpha. Muralidharan V, et al. J Cell Biochem, 1997 Sep 15. PMID 9282330
    2. Regulation of mouse myelin basic protein gene transcription by a sequence-specific single-stranded DNA-binding protein in vitro. Steplewski A, et al. Gene, 1995 Mar 10. PMID 7534248
    3. Identification of a sequence-specific single-stranded DNA binding protein that suppresses transcription of the mouse myelin basic protein gene. Haas S, et al. J Biol Chem, 1995 May 26. PMID 7539003
    4. A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells. van Riel B, et al. Mol Cell Biol, 2012 Oct. PMID 22801375, Free PMC Article
    5. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RUNX1 interacts with two novel protein partners, LSD1 and MYEF2, in erythroid cells.
      Title: A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myelin expression factor 2
    Names
    MEF-2
    myEF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162417.2 → NP_001155889.1  myelin expression factor 2 isoform 1

      See identical proteins and their annotated locations for NP_001155889.1

      Status: VALIDATED

      Source sequence(s)
      AL928902, AL929451
      Consensus CDS
      CCDS50691.1
      UniProtKB/Swiss-Prot
      Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
      UniProtKB/TrEMBL
      A2ATP6
      Related
      ENSMUSP00000123088.2, ENSMUST00000152367.8
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515 → 591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    2. NM_001162418.2 → NP_001155890.1  myelin expression factor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928902, AL929451
      Consensus CDS
      CCDS50689.1
      UniProtKB/TrEMBL
      A2ATP5, A2ATP6
      Related
      ENSMUSP00000114817.2, ENSMUST00000147105.8
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 546
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226 → 299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:474 → 550
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    3. NM_001401843.1 → NP_001388772.1  myelin expression factor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL928902, AL929451
      UniProtKB/Swiss-Prot
      Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1

    4. NM_010852.3 → NP_034982.2  myelin expression factor 2 isoform 2

      See identical proteins and their annotated locations for NP_034982.2

      Status: VALIDATED

      Source sequence(s)
      AL928902, AL929451
      Consensus CDS
      CCDS50690.1
      UniProtKB/TrEMBL
      A7UQY4
      Related
      ENSMUSP00000066312.4, ENSMUST00000067780.10
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 570
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226 → 299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:498 → 574
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      124922894..124966727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248228.2 → XP_030104088.1  myelin expression factor 2 isoform X3

      UniProtKB/TrEMBL
      A2ATP5, A2ATP6
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 546
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226 → 299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:474 → 550
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    2. XM_006498884.4 → XP_006498947.1  myelin expression factor 2 isoform X2

      See identical proteins and their annotated locations for XP_006498947.1

      UniProtKB/TrEMBL
      A7UQY4
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 570
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226 → 299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:498 → 574
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    3. XM_017316131.3 → XP_017171620.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
      UniProtKB/TrEMBL
      A2ATP6
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515 → 591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    4. XM_017316134.3 → XP_017171623.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
      UniProtKB/TrEMBL
      A2ATP6
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515 → 591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    5. XM_017316132.3 → XP_017171621.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q60690, Q6P930, Q6ZPT3, Q8C854, Q8QZZ1
      UniProtKB/TrEMBL
      A2ATP6
      Conserved Domains (4) summary
      TIGR01628
      Location:115 → 587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12658
      Location:92 → 167
      RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12660
      Location:224 → 299
      RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515 → 591
      RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

    RNA

    1. XR_001781149.3 RNA Sequence

    2. XR_001781148.3 RNA Sequence

    3. XR_004938788.1 RNA Sequence

    4. XR_004938787.1 RNA Sequence

    5. XR_001781147.3 RNA Sequence

    6. XR_001781150.1 RNA Sequence

    7. XR_001781152.3 RNA Sequence

    8. XR_004938789.1 RNA Sequence

    9. XR_001781151.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C854.1 GenPept UniProtKB/Swiss-Prot:Q8C854

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