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    Mx2 MX dynamin-like GTPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 17858, updated on 27-Feb-2024

    Summary

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    Official Symbol
    Mx2provided by MGI
    Official Full Name
    MX dynamin-like GTPase 2provided by MGI
    Primary source
    MGI:MGI:97244
    See related
    Ensembl:ENSMUSG00000023341 AllianceGenome:MGI:97244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mx-2
    Summary
    This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to vesicular stomatitis virus, a member of the rhabdovirus family, but not to influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a frameshift that inactivates this gene product. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Ubiquitous expression in liver E18 (RPKM 1.6), large intestine adult (RPKM 1.0) and 27 other tissues See more
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    Genomic context

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    See Mx2 in Genome Data Viewer
    Location:
    16 C4; 16 57.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97337281..97362101)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97536081..97560901)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41629 Neighboring gene MX dynamin-like GTPase 1 Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene STARR-seq mESC enhancer starr_41630 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41631 Neighboring gene STARR-seq mESC enhancer starr_41632 Neighboring gene transmembrane protease, serine 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:97814757-97815058 Neighboring gene STARR-seq mESC enhancer starr_41635 Neighboring gene predicted gene, 41512

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Mx2 protein inhibits hantavirus but not influenza virus replication. Jin HK, et al. Arch Virol, 2001. PMID 11266216
    2. Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. Jin HK, et al. J Virol, 1999 Jun. PMID 10233954, Free PMC Article
    3. ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis. Imbert A, et al. Sci Data, 2021 Dec 3. PMID 34862403, Free PMC Article
    4. Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor. Nürnberger C, et al. J Virol, 2016 Dec 1. PMID 27654285, Free PMC Article
    5. INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. LINDENMANN J. Proc Soc Exp Biol Med, 1964 Jun. PMID 14193387

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized.
      Title: Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within innate immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to type I interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to virus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced GTP-binding protein Mx2
    Names
    myxovirus (influenza virus) resistance 2
    myxovirus resistance protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013606.1 → NP_038634.1  interferon-induced GTP-binding protein Mx2

      See identical proteins and their annotated locations for NP_038634.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. This variant is not expressed in the mouse reference genome strain.
      Source sequence(s)
      AB029920
      UniProtKB/Swiss-Prot
      Q922L4, Q9WVP9
      Conserved Domains (3) summary
      cd08771
      Location:61 → 333
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:254 → 539
      Dynamin_M; Dynamin central region
      pfam02212
      Location:567 → 653
      GED; Dynamin GTPase effector domain

    RNA

    1. NR_003508.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant is expressed by the mouse reference genome strain.
      Source sequence(s)
      AI528743, AK143831, CT009632
      Related
      ENSMUST00000188251.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      97337281..97362101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVP9.2 GenPept UniProtKB/Swiss-Prot:Q9WVP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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