Mx1 MX dynamin-like GTPase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mx1provided by MGI
Official Full Name: MX dynamin-like GTPase 1provided by MGI
Primary source: MGI:MGI:97243
See related: Ensembl:ENSMUSG00000000386 AllianceGenome:MGI:97243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mx; Mx-1
Summary: This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Broad expression in liver E18 (RPKM 2.1), mammary gland adult (RPKM 1.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 57.46 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (97248235..97264106, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (97447035..97462906, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential lung gene expression changes in C57BL/6 and DBA/2 mice carrying an identical functional Mx1 gene reveals crucial differences in the host response.
Title: Differential lung gene expression changes in C57BL/6 and DBA/2 mice carrying an identical functional Mx1 gene reveals crucial differences in the host response.
Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription.
Title: Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription.
Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection.
Title: Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection.
Mouse Mx1 Inhibits Herpes Simplex Virus Type 1 Genomic Replication and Late Gene Expression In Vitro and Prevents Lesion Formation in the Mouse Zosteriform Model.
Title: Mouse Mx1 Inhibits Herpes Simplex Virus Type 1 Genomic Replication and Late Gene Expression In Vitro and Prevents Lesion Formation in the Mouse Zosteriform Model.
The R614E mutation of mouse Mx1 protein contributes to the novel antiviral activity against classical swine fever virus.
Title: The R614E mutation of mouse Mx1 protein contributes to the novel antiviral activity against classical swine fever virus.
Mx1 (+/+) mice with Mx1 (-/-) bone marrow failed to control Thogoto virus replication in the spleen. Mx1 in the hematopoietic cellular compartment thus contributes to protection against Thogoto virus infection.
Title: Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.
Genetic dominance of protective myxovirus (influenza virus) resistance 1 protein (Mx1) haplotypes was observed to differ by subspecies of origin.
Title: Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice.
Our studies emphasize therefore that proper controls are crucial when modeling gene deletion using the Mx1-Cre transgene.
Title: Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis.
the enhanced influenza virus susceptibility of CAST/EiJ mice can be explained by minor alterations in the MX1 restriction factor that negatively affect its enzymatic activity and reduce its half-life
Title: Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.
Data indicate that Mx protein as host defense peptide can be potentiated for improving influenza vaccine efficacy.
Title: Improvement influenza HA2 DNA vaccine cellular and humoral immune responses with Mx bio adjuvant.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Mx1 (e-PCR), detects polymorphism
- UniSTS:259108

Mx2 (e-PCR), detects polymorphism
- UniSTS:259109

Mx1 (e-PCR), detects polymorphism
- UniSTS:259635

Mx1 (e-PCR), detects polymorphism
- UniSTS:143937

Mx1 (e-PCR), detects polymorphism
- UniSTS:143938

Mx1 (e-PCR), detects polymorphism
- UniSTS:143939

M12279 (e-PCR)
- UniSTS:160604

AI893580 (e-PCR)
- UniSTS:166025

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within innate immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to virus	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Mx1

Names: interferon-induced GTP-binding protein Mx1; myxoma resistance protein 1; myxovirus (influenza virus) resistance 1; myxovirus (influenza) resistance 1 polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010846.1 → NP_034976.1 protein Mx1

See identical proteins and their annotated locations for NP_034976.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding allele found in the A2G strain.

Source sequence(s)

M12279

UniProtKB/Swiss-Prot

P09922

UniProtKB/TrEMBL

A0A1D8DGT1, Q4FJJ9

Conserved Domains (3) summary

smart00302
Location:538 → 629

GED; Dynamin GTPase effector domain

cd08771
Location:34 → 306

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:227 → 512

Dynamin_M; Dynamin central region

RNA

NR_003520.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the non-functional allele found in the reference strain. This variant lacks a portion of the central coding region, compared to the coding variant (1). This variant is represented as non-coding because there is no evidence for the synthesis of this protein in the reference strain.

Source sequence(s)

AK076430, AK150023

Related

ENSMUST00000113768.8