Laptm4a lysosomal-associated protein transmembrane 4A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Laptm4aprovided by MGI
Official Full Name: lysosomal-associated protein transmembrane 4Aprovided by MGI
Primary source: MGI:MGI:108017
See related: Ensembl:ENSMUSG00000020585 AllianceGenome:MGI:108017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTP; Mtrp; LAPTM4; mKIAA0108
Summary: Located in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human LAPTM4A (lysosomal protein transmembrane 4 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 244.4), limb E14.5 (RPKM 171.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 3.96 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (8972072..8988742)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (8921307..8938742)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that while some requisites of LAPTM5 lysosomal sorting are conserved among LAPTM4 proteins, LAPTM4a and LAPTM4b have also developed distinct sorting requirements.
Title: A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.
LAPTM4 alpha is the first example of a membrane protein that requires two tandemly arranged tyrosine-based sorting signals for efficient localization in lysosomes and endosomes.
Title: Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Laptm4a (e-PCR), detects polymorphism
- UniSTS:143932

BE292627 (e-PCR)
- UniSTS:208777

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysosomal-associated transmembrane protein 4A

Names: golgi 4-transmembrane-spanning transporter; membrane transporter protein; transporter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008640.3 → NP_032666.3 lysosomal-associated transmembrane protein 4A

Status: VALIDATED

Source sequence(s)

AC140354

Consensus CDS

CCDS36402.1

UniProtKB/TrEMBL

E9QLR3, Q8BG66

Related

ENSMUSP00000020909.5, ENSMUST00000020909.5

Conserved Domains (1) summary

cl04276
Location:10 → 221

Mtp; Golgi 4-transmembrane spanning transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

8972072..8988742

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157210.1 → XP_036013103.1 lysosomal-associated transmembrane protein 4A isoform X1

Conserved Domains (1) summary

cl04276
Location:3 → 145

Mtp; Golgi 4-transmembrane spanning transporter