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    Mtnr1a melatonin receptor 1A [ Mus musculus (house mouse) ]

    Gene ID: 17773, updated on 21-Apr-2024

    Summary

    Official Symbol
    Mtnr1aprovided by MGI
    Official Full Name
    melatonin receptor 1Aprovided by MGI
    Primary source
    MGI:MGI:102967
    See related
    Ensembl:ENSMUSG00000054764 AllianceGenome:MGI:102967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MR; MelR
    Summary
    Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of insulin secretion. Predicted to act upstream of or within signal transduction. Predicted to be located in neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; gonad; intestine; and liver and biliary system. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 1.3), liver adult (RPKM 0.1) and 3 other tissues See more
    Orthologs
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    Genomic context

    Location:
    8 B1.1; 8 24.95 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45522144..45542270)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45069107..45089233)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21352 Neighboring gene STARR-seq mESC enhancer starr_21353 Neighboring gene predicted gene 9908 Neighboring gene STARR-seq mESC enhancer starr_21356 Neighboring gene STARR-seq mESC enhancer starr_21359 Neighboring gene FAT atypical cadherin 1 Neighboring gene STARR-seq mESC enhancer starr_21360 Neighboring gene STARR-seq mESC enhancer starr_21361 Neighboring gene STARR-seq mESC enhancer starr_21364 Neighboring gene cDNA sequence AY512931 Neighboring gene STARR-seq mESC enhancer starr_21366 Neighboring gene predicted gene, 30504 Neighboring gene STARR-seq mESC enhancer starr_21368 Neighboring gene predicted gene 6329 Neighboring gene STARR-seq mESC enhancer starr_21369 Neighboring gene coagulation factor XI

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC151277

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables melatonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables melatonin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    melatonin receptor type 1A
    Names
    Mel1a receptor
    mel-1A-R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008639.3NP_032665.1  melatonin receptor type 1A

      See identical proteins and their annotated locations for NP_032665.1

      Status: VALIDATED

      Source sequence(s)
      AC158352
      Consensus CDS
      CCDS22273.1
      UniProtKB/Swiss-Prot
      Q61184
      UniProtKB/TrEMBL
      Q14AC3
      Related
      ENSMUSP00000069872.8, ENSMUST00000067984.9
      Conserved Domains (2) summary
      pfam00001
      Location:47298
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:38160
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      45522144..45542270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509292.2XP_006509355.2  melatonin receptor type 1A isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:3156
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:27275
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_017312597.1XP_017168086.1  melatonin receptor type 1A isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:3055
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:26274
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_011242176.1XP_011240478.1  melatonin receptor type 1A isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:328
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:3247
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. XM_006509291.3XP_006509354.1  melatonin receptor type 1A isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:328
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:3247
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily