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    Tesmin testis expressed metallothionein like [ Mus musculus (house mouse) ]

    Gene ID: 17771, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Tesminprovided by MGI
    Official Full Name
    testis expressed metallothionein likeprovided by MGI
    Primary source
    MGI:MGI:1340029
    See related
    Ensembl:ENSMUSG00000024905 AllianceGenome:MGI:1340029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtl5
    Summary
    Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in cytoplasm and nucleus. Is expressed in brain; gonad; heart; liver; and metanephros. Orthologous to human TESMIN (testis expressed metallothionein like protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 35.1) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 3.15 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3438857..3457823)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3388857..3407823)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene microRNA 6984 Neighboring gene STARR-seq mESC enhancer starr_45314 Neighboring gene carnitine palmitoyltransferase 1a, liver Neighboring gene galanin and GMAP prepropeptide Neighboring gene STARR-seq mESC enhancer starr_45317 Neighboring gene protein phosphatase 6, regulatory subunit 3 Neighboring gene predicted gene, 23940

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins. Oura S, et al. Sci Rep, 2022 Dec 23. PMID 36564444, Free PMC Article
    2. Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†. Oji A, et al. Biol Reprod, 2020 Apr 15. PMID 31916570, Free PMC Article
    3. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma. Huang Y, et al. Bioengineered, 2022 Mar. PMID 35249447, Free PMC Article
    4. Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility. Zhang X, et al. PLoS Genet, 2021 Aug. PMID 34388164, Free PMC Article
    5. Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes. Matsuura T, et al. J Inorg Biochem, 2002 Jan 15. PMID 11803038

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
      Title: Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
    2. Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
      Title: Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
    3. Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Micedagger.
      Title: Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†.
    4. regulation of the tesmin nucleocytoplasmic shuttling by the effect of metal stress
      Title: Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes.
    5. Data suggest that tesmin transcription may be controlled by two different mechanisms during male and female meiosis.
      Title: Tesmin transcription is regulated differently during male and female meiosis.
    6. tesmin is involved in multiple stages of spermatogenesis and spermiogenesis
      Title: Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tesmin
    Names
    metallothionein-like 5, testis-specific (tesmin)
    testis-specific metallothionein-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039657.2 → NP_001034746.1  tesmin isoform a

      See identical proteins and their annotated locations for NP_001034746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK015724, AK015732, AK161511
      Consensus CDS
      CCDS37880.1
      UniProtKB/Swiss-Prot
      Q548K4, Q8VIE0, Q8VIE1, Q9WTJ6
      Related
      ENSMUSP00000025840.10, ENSMUST00000025840.16
      Conserved Domains (1) summary
      pfam03638
      Location:334 → 371
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    2. NM_001039658.2 → NP_001034747.1  tesmin isoform b

      See identical proteins and their annotated locations for NP_001034747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK015732, AK161511
      Consensus CDS
      CCDS50339.1
      UniProtKB/TrEMBL
      Q9D571
      Related
      ENSMUSP00000114142.2, ENSMUST00000151341.8

    3. NM_001286557.1 → NP_001273486.1  tesmin isoform c

      See identical proteins and their annotated locations for NP_001273486.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AK015724, AK161511, AL626765
      Consensus CDS
      CCDS70912.1
      UniProtKB/Swiss-Prot
      Q9WTJ6
      Related
      ENSMUSP00000114171.2, ENSMUST00000142193.8
      Conserved Domains (1) summary
      pfam03638
      Location:154 → 191
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    4. NM_001286558.1 → NP_001273487.1  tesmin isoform c

      See identical proteins and their annotated locations for NP_001273487.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AK015724, AK161511, AL626765
      Consensus CDS
      CCDS70912.1
      UniProtKB/Swiss-Prot
      Q9WTJ6
      Related
      ENSMUSP00000122687.2, ENSMUST00000127142.2
      Conserved Domains (1) summary
      pfam03638
      Location:154 → 191
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      3438857..3457823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010841.1: Suppressed sequence

      Description
      NM_010841.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTJ6.2 GenPept UniProtKB/Swiss-Prot:Q9WTJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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