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    Mtf2 metal response element binding transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 17765, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mtf2provided by MGI
    Official Full Name
    metal response element binding transcription factor 2provided by MGI
    Primary source
    MGI:MGI:105050
    See related
    Ensembl:ENSMUSG00000029267 AllianceGenome:MGI:105050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M96; Pcl2; 9230112N11Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.1), CNS E14 (RPKM 6.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtf2 in Genome Data Viewer
    Location:
    5 F; 5 52.41 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108213518..108257085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108065660..108109219)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42150 Neighboring gene STARR-seq mESC enhancer starr_13899 Neighboring gene STARR-seq mESC enhancer starr_13900 Neighboring gene STARR-seq mESC enhancer starr_13901 Neighboring gene ribosomal protein S19, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_13902 Neighboring gene STARR-seq mESC enhancer starr_13904 Neighboring gene STARR-positive B cell enhancer ABC_E2166 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene coiled-coil domain containing 18 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of PRC2 subunits primes lineage choice during exit of pluripotency. Loh CH, et al. Nat Commun, 2021 Nov 30. PMID 34848733, Free PMC Article
    2. MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding. Perino M, et al. Nat Genet, 2018 Jul. PMID 29808031
    3. Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. Rothberg JLM, et al. Cell Discov, 2018. PMID 29736258, Free PMC Article
    4. Polycomblike-2-deficient mice exhibit normal left-right asymmetry. Wang S, et al. Dev Dyn, 2007 Mar. PMID 17266133
    5. WDR26 and MTF2 are therapeutic targets in multiple myeloma. Sun F, et al. J Hematol Oncol, 2021 Dec 7. PMID 34876184, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR26 and MTF2 are therapeutic targets in multiple myeloma.
      Title: WDR26 and MTF2 are therapeutic targets in multiple myeloma.
    2. Loss of PRC2 subunits primes lineage choice during exit of pluripotency.
      Title: Loss of PRC2 subunits primes lineage choice during exit of pluripotency.
    3. Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
      Title: Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
    4. MTF2 selectively binds regions with a high density of unmethylated CpGs in a context of reduced helix twist.
      Title: MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding.
    5. these studies identify JARID2, MTF2, and esPRC2p48 as important regulatory subunits of PRC2 in ES cells and reveal critical functions of these subunits
      Title: PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.
    6. Data show that Pcl2 differentially regulates Polycomb-mediated repression of Hox and Cdkn2a genes.
      Title: Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116639

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in segment specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metal-response element-binding transcription factor 2
    Names
    mPCl2
    metal regulatory transcription factor 2
    metal response element DNA-binding protein M96
    polycomb-like protein 2
    ziRF1
    zinc-regulated factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253877.1 → NP_001240806.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240806.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK031409, AK032819, BC092237, CJ311871
      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    2. NM_001253878.1 → NP_001240807.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240807.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK139685, BC092237, CJ311871
      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    3. NM_001253879.1 → NP_001240808.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK030752, AK031409, BC092237, CJ311871
      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    4. NM_001253880.1 → NP_001240809.1  metal-response element-binding transcription factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001240809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK031409, AK137539, BC092237, BC100340, CJ311871
      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    5. NM_001359088.1 → NP_001346017.1  metal-response element-binding transcription factor 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) encodes the longest isoform (3).
      Source sequence(s)
      AC134402
      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (4) summary
      cd15578
      Location:115 → 167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214 → 265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555 → 602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56 → 109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

    6. NM_001359089.1 → NP_001346018.1  metal-response element-binding transcription factor 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 7, which results in the use of a downstream AUG start codon. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AC134402
      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    7. NM_013827.3 → NP_038855.2  metal-response element-binding transcription factor 2 isoform 1

      See identical proteins and their annotated locations for NP_038855.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the 5' end compared to variant 7. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AK031409, AK137539, BC092237, CJ311871
      Consensus CDS
      CCDS39201.1
      UniProtKB/Swiss-Prot
      Q02395, Q05C61, Q569Z8, Q6PG89, Q8BGP9, Q8BSJ7
      UniProtKB/TrEMBL
      E9QAD3
      Related
      ENSMUSP00000080278.5, ENSMUST00000081567.11
      Conserved Domains (4) summary
      smart00333
      Location:45 → 95
      TUDOR; Tudor domain
      cd15578
      Location:104 → 156
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:203 → 254
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:544 → 590
      Mtf2_C; Polycomb-like MTF2 factor 2

    RNA

    1. NR_152817.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' end and uses an alternate splice junction in the 3' end compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC134402, AK137539

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108213518..108257085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164857.1 → XP_036020750.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    2. XM_036164854.1 → XP_036020747.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    3. XM_036164865.1 → XP_036020758.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    4. XM_036164861.1 → XP_036020754.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    5. XM_011249412.4 → XP_011247714.1  metal-response element-binding transcription factor 2 isoform X1

      See identical proteins and their annotated locations for XP_011247714.1

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (4) summary
      cd15578
      Location:115 → 167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214 → 265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555 → 602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56 → 109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

    6. XM_036164859.1 → XP_036020752.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    7. XM_036164853.1 → XP_036020746.1  metal-response element-binding transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (4) summary
      cd15578
      Location:115 → 167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214 → 265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555 → 602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56 → 109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

    8. XM_011249417.4 → XP_011247719.1  metal-response element-binding transcription factor 2 isoform X3

      Conserved Domains (3) summary
      cd15578
      Location:115 → 167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam18104
      Location:60 → 95
      Tudor_2; Jumonji domain-containing protein 2A Tudor domain
      cl22851
      Location:214 → 265
      PHD_SF; PHD finger superfamily

    9. XM_036164860.1 → XP_036020753.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    10. XM_030254193.2 → XP_030110053.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Related
      ENSMUST00000131264.8
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    11. XM_030254194.2 → XP_030110054.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    12. XM_036164863.1 → XP_036020756.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    13. XM_036164862.1 → XP_036020755.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    14. XM_030254189.2 → XP_030110049.1  metal-response element-binding transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (4) summary
      cd15578
      Location:115 → 167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214 → 265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555 → 602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56 → 109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

    15. XM_036164858.1 → XP_036020751.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    16. XM_036164855.1 → XP_036020748.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    17. XM_011249416.4 → XP_011247718.1  metal-response element-binding transcription factor 2 isoform X2

      See identical proteins and their annotated locations for XP_011247718.1

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    18. XM_036164866.1 → XP_036020759.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      E9QAD3
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 489
      Mtf2_C; Polycomb-like MTF2 factor 2

    RNA

    1. XR_389261.5 RNA Sequence

    2. XR_004942441.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02395.2 GenPept UniProtKB/Swiss-Prot:Q02395

    Gene LinkOut

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