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    Irag1 inositol 1,4,5-triphosphate receptor associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 17540, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Irag1provided by MGI
    Official Full Name
    inositol 1,4,5-triphosphate receptor associated 1provided by MGI
    Primary source
    MGI:MGI:1338023
    See related
    Ensembl:ENSMUSG00000005611 AllianceGenome:MGI:1338023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irag; Ris1; Mrvi1
    Summary
    This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein participates in signaling by nitric oxide (NO) to inhibit intracellular calcium release and platelet aggregation in cardiovascular tissue. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
    Expression
    Biased expression in bladder adult (RPKM 34.2), subcutaneous fat pad adult (RPKM 20.8) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E3; 7 57.9 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110467464..110582116, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110868257..110982909, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene ring finger protein 141 Neighboring gene STARR-positive B cell enhancer ABC_E2250 Neighboring gene STARR-seq mESC enhancer starr_19833 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene STARR-seq mESC enhancer starr_19834 Neighboring gene predicted gene 16336 Neighboring gene STARR-seq mESC enhancer starr_19835 Neighboring gene STARR-seq mESC enhancer starr_19836 Neighboring gene STARR-positive B cell enhancer ABC_E9701 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene eukaryotic translation initiation factor 4, gamma 2 Neighboring gene predicted gene, 23262

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of PKGIβ/IRAG1 Signaling Causes Anemia-Associated Splenomegaly. Majer M, et al. Int J Mol Sci, 2021 May 21. PMID 34064290, Free PMC Article
    2. IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension. Biswas S, et al. Cells, 2020 Oct 13. PMID 33066124, Free PMC Article
    3. IRAG and novel PKG targeting in the cardiovascular system. Schlossmann J, et al. Am J Physiol Heart Circ Physiol, 2011 Sep. PMID 21666108
    4. InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinases. Masuda W, et al. J Biol Chem, 2010 Nov 26. PMID 20876535, Free PMC Article
    5. Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation. Schinner E, et al. Platelets, 2011. PMID 21244222

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IRAG1 Deficient Mice Develop PKG1beta Dependent Pulmonary Hypertension.
      Title: IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension.
    2. cGKIbeta signaling via IRAG is essential for regulation of smooth muscle tone and of intracellular calcium by NO and by atrial natriuretic peptide.
      Title: IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation.
    3. conclude that cGMP-dependent relaxation of hormone receptor-triggered smooth muscle contraction essentially depends on the interaction of cGKI-IRAG with IP(3)RI
      Title: IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase.
    4. Reports use of non-AUG (CUG) translation initiation codon in one of the transcript variants of MRVI1 gene in mouse and human.
      Title: Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within relaxation of vascular associated smooth muscle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,4,5-triphosphate receptor associated 1
    Names
    JAW1-related protein MRVI1
    MRV integration site 1
    inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
    inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
    murine retrovirus integration site 1 protein
    protein MRVI1
    retroviral integration site 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194464.3 → NP_919446.2  inositol 1,4,5-triphosphate receptor associated 1

      See identical proteins and their annotated locations for NP_919446.2

      Status: REVIEWED

      Source sequence(s)
      AC159206, AC184052, AK020536, AK141821
      Consensus CDS
      CCDS21749.1
      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Related
      ENSMUSP00000005751.7, ENSMUST00000005751.13
      Conserved Domains (1) summary
      pfam05781
      Location:272 → 856
      MRVI1; MRVI1 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      110467464..110582116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507416.3 → XP_006507479.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

      See identical proteins and their annotated locations for XP_006507479.1

      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Related
      ENSMUSP00000114578.2, ENSMUST00000125758.8
      Conserved Domains (1) summary
      pfam05781
      Location:272 → 856
      MRVI1; MRVI1 protein

    2. XM_006507415.4 → XP_006507478.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

      See identical proteins and their annotated locations for XP_006507478.1

      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Conserved Domains (1) summary
      pfam05781
      Location:272 → 856
      MRVI1; MRVI1 protein

    3. XM_036152758.1 → XP_036008651.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

      UniProtKB/TrEMBL
      Q3UR44
      Conserved Domains (1) summary
      pfam05781
      Location:24 → 608
      MRVI1; MRVI1 protein

    4. XM_006507418.5 → XP_006507481.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

      UniProtKB/TrEMBL
      Q3UR44
      Conserved Domains (1) summary
      pfam05781
      Location:24 → 608
      MRVI1; MRVI1 protein

    5. XM_011241686.1 → XP_011239988.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Related
      ENSMUSP00000120045.2, ENSMUST00000127935.8
      Conserved Domains (2) summary
      pfam05781
      Location:289 → 873
      MRVI1; MRVI1 protein
      cl19857
      Location:122 → 213
      DUF2126; Putative amidoligase enzyme (DUF2126)

    6. XM_011241687.4 → XP_011239989.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X4

      Conserved Domains (1) summary
      pfam05781
      Location:337 → 490
      MRVI1; MRVI1 protein

    RNA

    1. XR_869664.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010826.5: Suppressed sequence

      Description
      NM_010826.5: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUX5.2 GenPept UniProtKB/Swiss-Prot:Q9WUX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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