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    Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [ Mus musculus (house mouse) ]

    Gene ID: 17463, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Psmd7provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 7provided by MGI
    Primary source
    MGI:MGI:1351511
    See related
    Ensembl:ENSMUSG00000039067 AllianceGenome:MGI:1351511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mov34; Mov-34
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including brain; liver; metanephros; placenta; and spleen. Orthologous to human PSMD7 (proteasome 26S subunit, non-ATPase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 54.8), liver E14 (RPKM 52.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 54.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108307012..108315114, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107580380..107588482, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_22610 Neighboring gene predicted gene, 51547 Neighboring gene STARR-positive B cell enhancer ABC_E11397 Neighboring gene microRNA 140 Neighboring gene STARR-seq mESC enhancer starr_22613 Neighboring gene STARR-seq mESC enhancer starr_22614 Neighboring gene STARR-seq mESC enhancer starr_22615 Neighboring gene STARR-seq mESC enhancer starr_22616 Neighboring gene predicted gene 8940 Neighboring gene STARR-seq mESC enhancer starr_22618 Neighboring gene predicted gene, 42040 Neighboring gene predicted gene, 39242

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mov34 protein from mouse brain interacts with the 3' noncoding region of Japanese encephalitis virus. Ta M, et al. J Virol, 2000 Jun. PMID 10799585, Free PMC Article
    2. Molecular cloning and expression of subunit 12: a non-MCP and non-ATPase subunit of the 26 S protease. Dubiel W, et al. FEBS Lett, 1995 Apr 17. PMID 7729561
    3. The murine Mov-34 gene: full-length cDNA and genomic organization. Gridley T, et al. Genomics, 1991 Nov. PMID 1837787
    4. cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product. Tsurumi C, et al. Biochem Biophys Res Commun, 1995 May 16. PMID 7755639
    5. Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death. Soriano P, et al. Genes Dev, 1987 Jun. PMID 2824282

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.
      Title: Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 7
    Names
    26S proteasome regulatory subunit S12
    26S proteasome regulatory subunit rpn8
    proteasome subunit p40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010817.2 → NP_034947.1  26S proteasome non-ATPase regulatory subunit 7

      See identical proteins and their annotated locations for NP_034947.1

      Status: VALIDATED

      Source sequence(s)
      AC134855, AW492454, BC130014
      Consensus CDS
      CCDS22650.1
      UniProtKB/Swiss-Prot
      P26516, Q3TW61, Q8C0I8
      UniProtKB/TrEMBL
      A1L3B8
      Related
      ENSMUSP00000041968.5, ENSMUST00000044106.6
      Conserved Domains (2) summary
      cd08062
      Location:7 → 285
      MPN_RPN7_8; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
      PLN03246
      Location:6 → 284
      PLN03246; 26S proteasome regulatory subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      108307012..108315114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26516.2 GenPept UniProtKB/Swiss-Prot:P26516

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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